Výsledky vyhledávání - "Anne‑Coline Laurent"

Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling

Autor: Alexandre Lucas, Aude Saulière, George S. Baillie, Anne-Coline Laurent, Céline Galés, Magali Berthouze-Duquesnes, Yuan Yan Sin, Frank Lezoualc'h

Publikováno v: Cell Signal
Cell Signal, 2013, 25 (4), pp.970-80. ⟨10.1016/j.cellsig.2012.12.007⟩

International audience; β1 and β2 adrenergic receptors (βARs) are highly homologous but fulfill distinct physiological and pathophysiological roles. Here we show that both βAR subtypes activate the cAMP-binding protein Epac1, but they differentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50921a6ab1201fc63978c7e0932db035
https://doi.org/10.1016/j.cellsig.2012.12.007

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New Perspectives in cAMP-Signaling Modulation

Autor: Magali Berthouze, Anne-Coline Laurent, Frank Lezoualc'h, Magali Breckler

Publikováno v: Current Heart Failure Reports
Current Heart Failure Reports, Current Medicine Group, 2011, 8 (3), pp.159-67. ⟨10.1007/s11897-011-0062-8⟩
Current Heart Failure Reports, 2011, 8 (3), pp.159-67. ⟨10.1007/s11897-011-0062-8⟩

International audience; Cyclic adenosine 3',5'-monophosphate (cAMP) mediates the biological effects of various hormones and neurotransmitters. Stimulation of cardiac β-adrenergic receptors (β-AR) via catecholamines leads to activation of adenylyl c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221d1c08e14fef9f392a224609aabe06
https://doi.org/10.1007/s11897-011-0062-8

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Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway

Autor: Eric Morel, Bertrand Crozatier, Anne-Coline Laurent, Isabelle Hmitou, Mélanie Métrich, Nicolas Duquesnes, Magali Breckler, Delphine Courillau, Jean-Paul Blondeau, Frank Lezoualc'h

Publikováno v: Cellular Signalling. 22:1459-1468

Epac (Exchange protein directly activated by cAMP) is a sensor for cAMP and represents a novel mechanism for governing cAMP signalling. Epac is a guanine nucleotide exchange factor (GEF) for the Ras family of small GTPases, Rap. Previous studies demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8885540f71125868598b3293fd6e1d4
https://doi.org/10.1016/j.cellsig.2010.05.014

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Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy

Autor: Annélie de Régibus, Audrey Swiader, Alexandre Lucas, Christophe Heymes, Yannis Sainte-Marie, Marie Roumieux, Florence Tortosa, Anne-Coline Laurent, Malik Bisserier, Frank Lezoualc'h, Cécile Vindis

Publikováno v: Cardiovascular research. 105(1)

Aims Stimulation of β-adrenergic receptors (β-AR) increases cAMP production and contributes to the pathogenesis of cardiac hypertrophy and failure through poorly understood mechanisms. We previously demonstrated that Exchange protein directly activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f1260ef3e7cb7eb70437d0152bbf1a
https://pubmed.ncbi.nlm.nih.gov/25411381

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Carabin protects against cardiac hypertrophy by blocking calcineurin, Ras, and Ca2+/calmodulin-dependent protein kinase II signaling

Autor: Claudine Deloménie, Anne-Coline Laurent, Maxime Branchereau, Frank Lezoualc'h, Olivier Cazorla, Loubina Fazal, Alexandre Lucas, Pauline Soulas-Sprauel, Florence Tortosa, Magali Breckler, Pauline Marck, Christophe Heymes, Eric Morel, Magali Berthouze-Duquesnes, Bertrand Crozatier, Audrey Varin, Jean-Nicolas Schickel, Malik Bisserier, Annélie de Régibus

Publikováno v: Circulation. 131(4)

Background— Cardiac hypertrophy is an early hallmark during the clinical course of heart failure and is regulated by various signaling pathways. However, the molecular mechanisms that negatively regulate these signal transduction pathways remain po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f56567a62dcb2278d6cfeec469659b
https://pubmed.ncbi.nlm.nih.gov/25369805

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Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke

Autor: Junjun Cao, Machteld N. Hylkema, Anne Coline Laurent, Anouk Oldenburger, Frank Lezoualc'h, Alan V. Smrcka, H. Maarsingh, Marieke Smit, Herman Meurs, Sophie Bos, Martina Schmidt, Wim Timens

Publikováno v: The FASEB Journal, 28(11), 4617-4628. FEDERATION AMER SOC EXP BIOL

Cigarette smoke (CS) induces inflammatory responses characterized by increase of immune cells and cytokine release. Remodeling processes, such as mucus hypersecretion and extracellular matrix protein production, are also directly or indirectly induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc5fda645f703b8e392475d0a8f77d5
https://europepmc.org/articles/PMC4200332/

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Role of Epac in brain and heart

Autor: Anne‑Coline Laurent, Magali Breckler, Frank Lezoualc'h, Magali Berthouze

Publikováno v: Biochemical Society Transactions
Biochemical Society Transactions, Portland Press, 2012, 40 (1), pp.51-7. ⟨10.1042/BST20110642⟩
Biochemical Society Transactions, 2012, 40 (1), pp.51-7. ⟨10.1042/BST20110642⟩

International audience; Epacs (exchange proteins directly activated by cAMP) are guanine-nucleotide-exchange factors for the Ras-like small GTPases Rap1 and Rap2. Epacs were discovered in 1998 as new sensors for the second messenger cAMP acting in pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43e4510fcd467cadf40204d4af058db
https://www.hal.inserm.fr/inserm-01009688

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Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications

Autor: Anne-Coline Laurent, Magali Breckler, Bertrand Crozatier, Frank Lezoualc'h, Eric Morel, Magali Berthouze

Publikováno v: Cell Signal
Cell Signal, 2011, 23 (8), pp.1257-66. ⟨10.1016/j.cellsig.2011.03.007⟩

International audience; Epac proteins respond to the second messenger cyclic AMP (cAMP) and are activated by Gs coupled receptors. They act as specific guanine nucleotide exchange factors (GEFs) for the small G proteins, Rap1 and Rap2 of the Ras fami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0562bdc6b87ea834007d56f54c7f8c
https://pubmed.ncbi.nlm.nih.gov/21402149

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