Prednisolone Treatment Does Not Interfere with 2′-O-Methyl Phosphorothioate Antisense-Mediated Exon Skipping in Duchenne Muscular Dystrophy

Autor: Annemieke Aartsma-Rus, Anne Vroon, Ingrid G.M. Kolfschoten, Judith C.T. van Deutekom, Ingrid E.C. Verhaart, Gert-Jan B. van Ommen, Hans Heemskerk, Tatyana G Karnaoukh

Publikováno v: Human Gene Therapy, 23(3), 262-273

In Duchenne muscular dystrophy (DMD), dystrophin deficiency leading to progressive muscular degeneration is caused by frame-shifting mutations in the DMD gene. Antisense oligonucleotides (AONs) aim to restore the reading frame by skipping of a specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a115add3978ade836395f597903cd69
https://doi.org/10.1089/hum.2011.127

Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4

Autor: Anne Vroon, Maria Stella Lombardi, Pieter M. Cobelens, Cobi Jacoba Johanna Heijnen, Annemieke Kavelaars, Marc G. Caron, Federico Mayor

Publikováno v: Journal of Leukocyte Biology. 75:901-909

Chemokine receptors belong to the family of G-protein-coupled receptors (GPCR). Phosphorylation of GPCR by GPCR kinases (GRKs) is considered to play an important role in desensitization of these receptors. We have recently shown in patients with rheu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681cb10bb650725360c7ac1e39e17946
https://doi.org/10.1189/jlb.0403136

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain

Autor: Anil K. Sood, Anne Vroon, Huijing Wang, Yoshihiro Ishikawa, Annemieke Kavelaars, Cindy T. J. van Velthoven, Hanneke L.D.M. Willemen, Niels Eijkelkamp, Xinna Zhang, Cobi Jacoba Johanna Heijnen

Chronic pain is a major clinical problem, yet the mechanisms underlying the transition from acute to chronic pain remain poorly understood. In mice, reduced expression of GPCR kinase 2 (GRK2) in nociceptors promotes cAMP signaling to the guanine nucl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ffc0b134897fd72b2c8a06c43ef48c
https://europepmc.org/articles/PMC3859388/

Combining doublecortin-like kinase silencing and vinca alkaloids results in a synergistic apoptotic effect in neuroblastoma cells

Autor: Erno Vreugdenhil, Yu Qin, Sou Cheng, Anne Vroon, Carla S Verissimo, Bob van de Water, Judith C.T. van Deutekom, Erik H.J. Danen, Carlos P. Fitzsimons, Leo S. Price, Jordi Carreras Puigvert

Publikováno v: The Journal of Pharmacology and experimental Therapeutics, 342(1), 119-130. American Society for Pharmacology and Experimental Therapeutics

Microtubule-destabilizing agents, such as vinca alkaloids (VAs), are part of the treatment currently applied in patients with high-risk neuroblastoma (NB). However, the development of drug resistance and toxicity make NB difficult to treat with these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9470e2943bf6fb14c8575f795f619e3d
https://dare.uva.nl/personal/pure/en/publications/combining-doublecortinlike-kinase-silencing-and-vinca-alkaloids-results-in-a-synergistic-apoptotic-effect-in-neuroblastoma-cells(737ef312-73ad-49ae-a508-0f4dc6a1475f).html

Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system:microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb

Autor: Patrick Cras, John J. P. Brevé, Jane K. Relton, Anne Marie Van Dam, John G.J.M. Bol, Piet V.J.M. Hoogland, Anne Vroon, Stuart M. Allan, Benjamin Drukarch

Publikováno v: Vroon, A, Drukarch, B, Bol, J G J M, Cras, P, Brevé, J J P, Allan, S M, Relton, J K, Hoogland, P V J M & Van Dam, A-M 2007, ' Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system : microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb ', Experimental Gerontology, vol. 42, no. 8, pp. 762-71 . https://doi.org/10.1016/j.exger.2007.04.010
Experimental Gerontology, 42(8), 762-71. Elsevier Inc.
Experimental gerontology

Neuroinflammation may play a role in the pathogenesis of Parkinson's disease (PD). The present study questioned whether this neuroinflammatory response differs between the olfactory bulb, as an early affected region and the nigrostriatal system. Inde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d618b85fa18f21b4b4a39ffd918fe9df
https://research.vumc.nl/en/publications/8b96758a-c232-4c7a-8501-fb1d5ab08678