Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Anne, Spang"'
Autor:
Curdin A. Franziscus, Danilo Ritz, N. Constantin Kappel, Jachen A. Solinger, Alexander Schmidt, Anne Spang
Publikováno v:
FEBS Open Bio, Vol 14, Iss 3, Pp 390-409 (2024)
Post‐translational modifications are key in the regulation of activity, structure, localization, and stability of most proteins in eukaryotes. Phosphorylation is potentially the most studied post‐translational modification, also due to its revers
Externí odkaz:
https://doaj.org/article/8c086ab10ffc434e87e477eac3e404ff
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
It is estimated that about 80% of endocytosed material is recycled back to the plasma membrane. Here, the authors show that kiss-and-run of Rab5 early endocytic and Rab11 recycling vesicles on sorting endosomes allow cargo flow, providing more robust
Externí odkaz:
https://doaj.org/article/3b8afb66e3334fb4a001de0dee7b7b92
Autor:
Dominik P. Buser, Anne Spang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Retrograde transport from endosomes to the trans-Golgi network is essential for recycling of protein and lipid cargoes to counterbalance anterograde membrane traffic. Protein cargo subjected to retrograde traffic include lysosomal acid-hydrolase rece
Externí odkaz:
https://doaj.org/article/fb3a8343771e40c4ad07f68937996910
Autor:
Carla E. Cadena del Castillo, J. Thomas Hannich, Andres Kaech, Hirohisa Chiyoda, Jonathan Brewer, Masamitsu Fukuyama, Nils J. Færgeman, Howard Riezman, Anne Spang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Cellular cholesterol levels are tightly regulated. Here, the authors show that the hedgehog signalling receptor PTCH is a cholesterol transporter. Reduction in PTCH activity leads to cellular cholesterol accumulation, changes in nuclear hormone recep
Externí odkaz:
https://doaj.org/article/5e7eddb79b0041a6b55bc4fe25d73484
Autor:
Anna L. L. Matos, Fabian Keller, Tristan Wegner, Carla Elizabeth Cadena del Castillo, David Grill, Sergej Kudruk, Anne Spang, Frank Glorius, Andreas Heuer, Volker Gerke
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Matos et al characterise previously developed cholesterol analogues, named CHIMs, which can be fluorescently labelled by click-chemistry. They find that CHIMs segregate similarly to cholesterol in lipid bilayers, allow the visualisation of cholestero
Externí odkaz:
https://doaj.org/article/6b36ae3d947f489d9b59bc1192d85ba4
Autor:
Anne Spang
Publikováno v:
Microbial Cell, Vol 8, Iss 5, Pp 87-90 (2021)
Eukaryotic cells are complicated factories that need ensure productivity and functionality on the cellular level as well as being able to communicate with their environment. In order to do so cells developed intracellular communication systems. For a
Externí odkaz:
https://doaj.org/article/4b48b27be456434eaed5f7749d7dd011
Publikováno v:
eLife, Vol 10 (2021)
Cell-cell communication is an essential process in life, with endosomes acting as key organelles for regulating uptake and secretion of signaling molecules. Endocytosed material is accepted by the sorting endosome where it either is sorted for recycl
Externí odkaz:
https://doaj.org/article/4b601ec39ade4cea9b69453c24f22015
Autor:
Hirohisa Chiyoda, Masahiko Kume, Carla Cadena Del Castillo, Kenji Kontani, Anne Spang, Toshiaki Katada, Masamitsu Fukuyama
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009457 (2021)
Spatiotemporal restriction of signaling plays a critical role in animal development and tissue homeostasis. All stem and progenitor cells in newly hatched C. elegans larvae are quiescent and capable of suspending their development until sufficient fo
Externí odkaz:
https://doaj.org/article/b0a9882bbb8243e784ddc8c6ac1a01e3
Autor:
Anna L. L. Matos, Fabian Keller, Tristan Wegner, Carla Elizabeth Cadena del Castillo, David Grill, Sergej Kudruk, Anne Spang, Frank Glorius, Andreas Heuer, Volker Gerke
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/1ee820d43a504d5b893c6e6f767930b1
Autor:
Nitish Mittal, Joao C. Guimaraes, Thomas Gross, Alexander Schmidt, Arnau Vina-Vilaseca, Danny D. Nedialkova, Florian Aeschimann, Sebastian A. Leidel, Anne Spang, Mihaela Zavolan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The transcription factor Gcn4 is known to regulate yeast amino acid synthesis. Here, the authors show that Gcn4 also acts as a repressor of protein biosynthesis in a range of conditions that enhance yeast lifespan, such as ribosomal protein knockout,
Externí odkaz:
https://doaj.org/article/b6439a80872547a384d1bede0c79d78b