Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Anne, Roulston"'
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998
https://doi.org/10.1021/acs.jmedchem.2c00998
Autor:
Haipeng Liu, Danmei Su, Jinlong Zhang, Shuaishuai Ge, Youwei Li, Fei Wang, Michel Gravel, Anne Roulston, Qin Song, Wei Xu, Joshua G. Liang, Gordon Shore, Xiaodong Wang, Peng Liang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) has long been considered a tantalizing target for cancer therapy because it mediates activation of the extrinsic apoptosis pathway in a tumor-specific manner by binding to and trimerizing i
Externí odkaz:
https://doaj.org/article/689ba978ac0b499ca617fd53fe206c90
Autor:
W. Cameron Black, Michael Zinda, Jordan T.F. Young, Zuomei Li, Yael Mamane, Rino Stocco, Martine Hamel, Artur Veloso, Victoria Rimkunas, Amina Mulani, Kathryn Skorey, Sabrina Vignini-Hammond, Chloe Fugère-Desjardins, William Yang, Hunain Alam, Amandine Chefson, Shou Yun Yin, Marie-Eve Leclaire, Li Li, Sara Fournier, Lee D. Fader, Stéphane Dorich, Valerie Dumais, Émilie Dumas-Bérube, Charles Pellerin, Alexander Skeldon, Robert Papp, Michal Zimmermann, Anne Roulston
Supplementary Methods, Tables, Figures and References
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062cfaf9177f49a3206feb599326f494
https://doi.org/10.1158/1535-7163.22896018
https://doi.org/10.1158/1535-7163.22896018
Autor:
W. Cameron Black, Michael Zinda, Jordan T.F. Young, Zuomei Li, Yael Mamane, Rino Stocco, Martine Hamel, Artur Veloso, Victoria Rimkunas, Amina Mulani, Kathryn Skorey, Sabrina Vignini-Hammond, Chloe Fugère-Desjardins, William Yang, Hunain Alam, Amandine Chefson, Shou Yun Yin, Marie-Eve Leclaire, Li Li, Sara Fournier, Lee D. Fader, Stéphane Dorich, Valerie Dumais, Émilie Dumas-Bérube, Charles Pellerin, Alexander Skeldon, Robert Papp, Michal Zimmermann, Anne Roulston
Ataxia telangiectasia and Rad3-related (ATR) kinase protects genome integrity during DNA replication. RP-3500 is a novel, orally bioavailable clinical-stage ATR kinase inhibitor (NCT04497116). RP-3500 is highly potent with IC50 values of 1.0 and 0.33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a51beae2425d617ba7d0ef61e96c7e6
https://doi.org/10.1158/1535-7163.c.6651330.v1
https://doi.org/10.1158/1535-7163.c.6651330.v1
Autor:
Anne Roulston, Gordon C. Shore, Daina Avizonis, Gaëlle Bridon, Alexandre Bramoullé, Michel Gravel, Manuel Chan
Figure S1 and Figure S2. S1: DUT knockdown sensitizes A549 cells to GMX treatment. S2: NAMPT knockdown sensitizes A549 cells to PTX treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadb96473f4c1f83f04d2be654f34d34
https://doi.org/10.1158/0008-5472.22404434.v1
https://doi.org/10.1158/0008-5472.22404434.v1
Autor:
Anne Roulston, Gordon C. Shore, Daina Avizonis, Gaëlle Bridon, Alexandre Bramoullé, Michel Gravel, Manuel Chan
GMX1778 and its prodrug GMX1777 represent a new class of cancer drugs that targets nicotinamide phosphoribosyltransferase (NAMPT) as a new strategy to interfere with biosynthesis of the key enzymatic cofactor NAD, which is critical for a number of ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0a084006dbe9112013cda84d717244
https://doi.org/10.1158/0008-5472.c.6506600
https://doi.org/10.1158/0008-5472.c.6506600
Autor:
Anne Roulston, Gordon C. Shore, Daina Avizonis, Gaëlle Bridon, Alexandre Bramoullé, Michel Gravel, Manuel Chan
Table S1. Potency of the combination of GMX and PTX in various cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ad96ba2cffe8962af9d3dabbfba90b
https://doi.org/10.1158/0008-5472.22404416
https://doi.org/10.1158/0008-5472.22404416
Autor:
Anne Roulston, Gordon C. Shore, Daina Avizonis, Gaëlle Bridon, Alexandre Bramoullé, Michel Gravel, Manuel Chan
Figure S3. Cell viability of PTX, GMX and PTX-GMX combo is affected by exogenous NMN and folic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0fe469c50f74e73245b7efdb1e52f0
https://doi.org/10.1158/0008-5472.22404428.v1
https://doi.org/10.1158/0008-5472.22404428.v1
Autor:
David Gallo, Jordan T. F. Young, Jimmy Fourtounis, Giovanni Martino, Alejandro Álvarez-Quilón, Cynthia Bernier, Nicole M. Duffy, Robert Papp, Anne Roulston, Rino Stocco, Janek Szychowski, Artur Veloso, Hunain Alam, Prasamit S. Baruah, Alexanne Bonneau Fortin, Julian Bowlan, Natasha Chaudhary, Jessica Desjardins, Evelyne Dietrich, Sara Fournier, Chloe Fugère-Desjardins, Theo Goullet de Rugy, Marie-Eve Leclaire, Bingcan Liu, Vivek Bhaskaran, Yael Mamane, Henrique Melo, Olivier Nicolas, Akul Singhania, Rachel K. Szilard, Ján Tkáč, Shou Yun Yin, Stephen J. Morris, Michael Zinda, C. Gary Marshall, Daniel Durocher
Publikováno v:
Nature. 604:749-756
Amplification of the CCNE1 locus on chromosome 19q12 is prevalent in multiple tumour types, particularly in high-grade serous ovarian cancer, uterine tumours and gastro-oesophageal cancers, where high cyclin E levels are associated with genome instab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc789be54b458503be76fad03b732048
https://doi.org/10.1038/s41586-022-04638-9
https://doi.org/10.1038/s41586-022-04638-9
Autor:
Anne Roulston, Michal Zimmermann, Robert Papp, Alexander Skeldon, Charles Pellerin, Émilie Dumas-Bérube, Valerie Dumais, Stéphane Dorich, Lee D. Fader, Sara Fournier, Li Li, Marie-Eve Leclaire, Shou Yun Yin, Amandine Chefson, Hunain Alam, William Yang, Chloe Fugère-Desjardins, Sabrina Vignini-Hammond, Kathryn Skorey, Amina Mulani, Victoria Rimkunas, Artur Veloso, Martine Hamel, Rino Stocco, Yael Mamane, Zuomei Li, Jordan T.F. Young, Michael Zinda, W. Cameron Black
Publikováno v:
Molecular Cancer Therapeutics. 21:245-256
Ataxia telangiectasia and Rad3-related (ATR) kinase protects genome integrity during DNA replication. RP-3500 is a novel, orally bioavailable clinical-stage ATR kinase inhibitor (NCT04497116). RP-3500 is highly potent with IC50 values of 1.0 and 0.33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c5c2c693c809fd51b04d00ce59692a4
https://doi.org/10.1158/1535-7163.mct-21-0615
https://doi.org/10.1158/1535-7163.mct-21-0615