Study protocol for a multicenter randomised controlled trial on the (cost)effectiveness of biopsy combined with same-session MR-guided LITT versus biopsy alone in patients with primary irresectable glioblastoma (EMITT trial)

Autor: Céline L.G. Neutel, Ilaria Viozzi, Christiaan G. Overduin, Anne Rijpma, Janneke P.C. Grutters, Gerjon Hannink, Pieter van Eijsden, Pierre A. Robe, Maroeska M. Rovers, Mark ter Laan

Publikováno v: BMC Cancer, Vol 23, Iss 1, Pp 1-8 (2023)

Abstract Background Glioblastoma (GBM) is the most common primary, malignant brain tumour with a 5-year survival of 5%. If possible, a glioblastoma is resected and further treated with chemoradiation therapy (CRT), but resection is not feasible in ab

Externí odkaz: https://doaj.org/article/0a533cfb59e2416ebe4b2fb2d52c9223

Altered brain high-energy phosphate metabolism in mild Alzheimer's disease: A 3-dimensional 31P MR spectroscopic imaging study

Autor: Anne Rijpma, Marinette van der Graaf, Olga Meulenbroek, Marcel G.M. Olde Rikkert, Arend Heerschap

Publikováno v: NeuroImage: Clinical, Vol 18, Iss , Pp 254-261 (2018)

In Alzheimer's disease (AD), defects in essential metabolic processes for energy supply and phospholipid membrane function have been implicated in the pathological process. However, post-mortem investigations are generally limited to late stage disea

Externí odkaz: https://doaj.org/article/1925ab80766244b4a3881eb0ad06d0a7

Orthostatic Blood Pressure Recovery Is Associated With the Rate of Cognitive Decline and Mortality in Clinical Alzheimer's Disease

Autor: Rianne A.A. de Heus, Daan L.K. de Jong, Anne Rijpma, Marcel G. M. Olde Rikkert, Jurgen A.H.R. Claassen, Brian A. Lawlor

Publikováno v: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 75, 11, pp. 2169-2176
Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 75, 2169-2176

Background Impaired recovery of blood pressure (BP) after standing has been shown to be related to cognitive function and mortality in people without dementia, but its role in people with Alzheimer’s disease (AD) is unknown. The aim of this study w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9adc7a7e16d1b6006c4a10f2441fcf80
https://doi.org/10.1093/gerona/glaa129

3D 31 P MR spectroscopic imaging of the human brain at 3 T with a 31 P receive array: An assessment of 1 H decoupling, T 1 relaxation times, 1 H‐ 31 P nuclear Overhauser effects and NAD +

Autor: Mark J. van Uden, Anne Rijpma, Arend Heerschap, Tom W. J. Scheenen, Tom H Peeters

Publikováno v: NMR in Biomedicine. 34

31 P MR spectroscopic imaging (MRSI) is a versatile technique to study phospholipid precursors and energy metabolism in the healthy and diseased human brain. However, mainly due to its low sensitivity, 31 P MRSI is currently limited to research purpo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a15169644597c59c58be73900620763
https://doi.org/10.1002/nbm.4169

Effects of Nilvadipine on Cerebral Blood Flow in Patients With Alzheimer Disease

Autor: Daan L K, de Jong, Rianne A A, de Heus, Anne, Rijpma, Rogier, Donders, Marcel G M, Olde Rikkert, Matthias, Günther, Brian A, Lawlor, Matthias J P, van Osch, Jurgen A H R, Claassen

Publikováno v: Hypertension (Dallas, Tex. : 1979). 74(2)

Cerebrovascular changes, including reduced cerebral blood flow (CBF), occur early in the development of Alzheimer disease and may accelerate disease progression. This randomized, double-blind, placebo-controlled study investigated how 6 months of tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af347d83d31979fcb32a7037b9d8c3c5
https://pubmed.ncbi.nlm.nih.gov/31203725