Quantifying Genomic Imprinting at Tissue and Cell Resolution in the Brain

Autor: Annie Varrault, Emeric Dubois, Anne Le Digarcher, Tristan Bouschet

Publikováno v: Epigenomes, Vol 4, Iss 3, p 21 (2020)

Imprinted genes are a group of ~150 genes that are preferentially expressed from one parental allele owing to epigenetic marks asymmetrically distributed on inherited maternal and paternal chromosomes. Altered imprinted gene expression causes human b

Externí odkaz: https://doaj.org/article/a6c2e5b48aeb40d4a8cc9c9f1949b471

CRISPR Activation/Inhibition Experiments Reveal that Expression of Intronic MicroRNA miR-335 Depends on the Promoter Activity of its Host Gene Mest

Autor: Tristan Bouschet, Charles C. Hong, Ilda Coku, Céline Lemmers, Arnaud Monteil, Anne Le Digarcher, Mathilde Courtes, Annie Varrault

MicroRNAs are small non-coding RNAs that act as rheostats to modulate gene expression during development, physiology, and disease. Approximately half of mammalian microRNAs are intronic. It is unknown whether intronic miRNA transcription depends on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f5e8275b6cd41051d54874122bf174e
https://doi.org/10.1101/2021.09.15.458166

Expression at the imprinted dlk1-gtl2 locus is regulated by proneural genes in the developing telencephalon.

Autor: Julie Seibt, Olivier Armant, Anne Le Digarcher, Diogo Castro, Vidya Ramesh, Laurent Journot, François Guillemot, Pierre Vanderhaeghen, Tristan Bouschet

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48675 (2012)

Imprinting is an epigenetic mechanism that restrains the expression of about 100 genes to one allele depending on its parental origin. Several imprinted genes are implicated in neurodevelopmental brain disorders, such as autism, Angelman, and Prader-

Externí odkaz: https://doaj.org/article/11a74fbaaed240cb9bcaebc6c3dae780

In Vitro Corticogenesis from Embryonic Stem Cells Recapitulates the In Vivo Epigenetic Control of Imprinted Gene Expression

Autor: Vincent Demolombe, Robert Sabatier, Laurent Journot, Satya K. Kota, Chloé Maurizy, Philippe Arnaud, Stéphanie Rialle, Anne Le Digarcher, Stéphanie Maupetit-Mehouas, Emeric Dubois, Annie Varrault, Patricia Cavelier, Robert Feil, Mikael Pezet, Céline Meusnier, Christelle Reynes, Sabine Nidelet, Tristan Bouschet

Publikováno v: Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2017, 〈10.1093/cercor/bhw102〉
Cerebral Cortex, Oxford University Press (OUP), 2017, ⟨10.1093/cercor/bhw102⟩
Cerebral Cortex, Oxford University Press (OUP), 2016, 〈10.1093/cercor/bhw102〉
Cerebral Cortex, 2017, ⟨10.1093/cercor/bhw102⟩

International audience; In vitro corticogenesis from embryonic stem cells (ESCs) is an attractive model of cortical development and a promising tool for corticaltherapy. It is unknown to which extent epigenetic mechanisms crucial for cortex developme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbc0dce06e9c2c5b544a04bbc53ae29
https://hal.archives-ouvertes.fr/hal-01934516

Genome-wide profiling of G protein-coupled receptors in cerebellar granule neurons using high-throughput, real-time PCR

Autor: Benjamin Maurel, Christelle Dantec, Anne Le Digarcher, Laurent Journot

Publikováno v: BMC Genomics, Vol 12, Iss 1, p 241 (2011)
BMC Genomics
BMC Genomics, BioMed Central, 2011, 12 (1), pp.241. ⟨10.1186/1471-2164-12-241⟩
BMC Genomics, 2011, 12 (1), pp.241. ⟨10.1186/1471-2164-12-241⟩

Background G protein-coupled receptors (GPCRs) are major players in cell communication, regulate a whole range of physiological functions during development and throughout adult life, are affected in numerous pathological situations, and constitute s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffae57156ac06c953b21dca9bbe2158
https://doi.org/10.1186/1471-2164-12-241