Venous Air Embolism Activates Complement C3 Without Corresponding C5 Activation and Trigger Thromboinflammation in Pigs

Autor: Benjamin S. Storm, Judith K. Ludviksen, Dorte Christiansen, Hilde Fure, Kristin Pettersen, Anne Landsem, Bent Aksel Nilsen, Knut Dybwik, Tonje Braaten, Erik W. Nielsen, Tom E. Mollnes

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

IntroductionAir embolism may complicate invasive medical procedures. Bubbles trigger complement C3-mediated cytokine release, coagulation, and platelet activation in vitro in human whole blood. Since these findings have not been verified in vivo, we

Externí odkaz: https://doaj.org/article/c0cd82a4cd91431ba31d6494add12eda

A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity

Autor: Jean M. H. van den Elsen, Camilla Schjalm, Ole-Lars Brekke, Tom Eirik Mollnes, Soeren Erik Pischke, Grethe Bergseth, Oliver Durrant, Linda M. Haugaard-Kedström, Anne Landsem, Alex Macpherson, Quang Huy Quach, Per H. Nilsson, Hilde Fure, Markus Huber-Lang, Christina Johnson

Publikováno v: J Immunol
Journal of Immunology
Nilsson, P H, Johnson, C, Quach, Q H, Macpherson, A, Durrant, O, Pischke, S E, Fure, H, Landsem, A, Bergseth, G, Schjalm, C, Haugaard-Kedström, L M, Huber-Lang, M, van den Elsen, J, Brekke, O L & Mollnes, T E 2021, ' A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity ', Journal of Immunology, vol. 207, no. 6, pp. 1641-1651 . https://doi.org/10.4049/jimmunol.2001471

Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged the concept of thrombin a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b448dc19a64a17108672b963fe184bed
http://hdl.handle.net/10852/88977

Systemic inflammation in acute intermittent porphyria: a case–control study

Autor: Anne Landsem, Tom Eirik Mollnes, Jim André Dahl, Bård Ove Karlsen, Judith K Ludviksen, Erik Waage Nielsen, S. Goldbeck‐Wood, Hilde Fure, Ole-Lars Brekke, Elin Storjord, K. S. Berg

Publikováno v: Clinical and Experimental Immunology. 187:466-479

Summary This study aimed to examine whether acute intermittent porphyria (AIP) is associated with systemic inflammation and whether the inflammation correlates with disease activity. A case–control study with 50 AIP cases and age-, sex- and place o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf25774df4e24426a5808f60f4075a4
https://doi.org/10.1111/cei.12899

Cholesterol Crystals Induce coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor

Autor: Anne Mari Rokstad, Bente Halvorsen, Terje Espevik, Eva A. Jacobsen, Tom Eirik Mollnes, Bjørg Steinkjer, Caroline S. Gravastrand, John D. Lambris, Ole-Lars Brekke, Mona Skjelland, Anne Landsem, Trent M. Woodruff

Publikováno v: Journal of Immunology

Cholesterol crystals (CC) are strong activators of complement and could potentially be involved in thromboinflammation through complement-coagulation cross-talk. To explore the coagulation-inducing potential of CC, we performed studies in lepirudin-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6bd85f115d783d86a6f5835d8cb162
https://hdl.handle.net/10037/18298

Lifestyle factors including diet and biochemical biomarkers in acute intermittent porphyria: Results from a case-control study in northern Norway

Autor: Jim André Dahl, Bård Ove Karlsen, Anne Landsem, Judith K Ludviksen, Elin Storjord, Ole-Lars Brekke, Marlene Karlsen

Background Lifestyle factors, including a low intake of carbohydrates, dieting, alcohol consumption, cigarette smoking and stress are some of the possible triggers of attacks in acute intermittent porphyria (AIP). The influence of lifestyle factors,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ebac6b83f11147d996040581377ea4
https://hdl.handle.net/10037/15306