Výsledky vyhledávání - "Anne, Klibanski"

Akademický článek

Low oxytocin levels are broadly associated with more pronounced psychopathology in anorexia nervosa with primarily restricting but not binge/purge eating behavior

Autor: Franziska Plessow, Francesca Galbiati, Kamryn T. Eddy, Madhusmita Misra, Karen K. Miller, Anne Klibanski, Anna Aulinas, Elizabeth A. Lawson

Publikováno v: Frontiers in Endocrinology, Vol 13 (2023)

ObjectiveAnorexia nervosa (AN) is commonly associated with depression, anxiety, and deficits in socioemotional functioning. Basal levels of oxytocin, a neurohormone with antidepressant, anxiolytic, and prosocial properties, are low in women with AN.

Externí odkaz: https://doaj.org/article/2b6446f3bd9b4fa49cdd2f1a2a7a244a

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Akademický článek

Sprouting Angiogenesis in Human Pituitary Adenomas

Autor: Jie Zhou, Yaomin Hu, Wende Zhu, Chuansheng Nie, Wenxiu Zhao, Alexander T. Faje, Kay E. Labelle, Brooke Swearingen, Hang Lee, E. Tessa Hedley-Whyte, Xun Zhang, Pamela S. Jones, Karen K. Miller, Anne Klibanski, Yunli Zhou, Roy J. Soberman

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

IntroductionAngiogenesis in pituitary tumors is not fully understood, and a better understanding could help inform new pharmacologic therapies, particularly for aggressive pituitary tumors.Materials and Methods219 human pituitary tumors and 12 normal

Externí odkaz: https://doaj.org/article/47bb963aef744161bbbf0c8bfbe4471c

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Akademický článek

High Histone Deacetylase 2/3 Expression in Non-Functioning Pituitary Tumors

Autor: Wenxiu Zhao, Xiaobin Jiang, Karrin Weisenthal, Jun Ma, Erin M. Botticelli, Yunli Zhou, E. Tessa Hedley-Whyte, Baiyao Wang, Brooke Swearingen, Roy J. Soberman, Anne Klibanski, Xun Zhang

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Epigenetic modification of chromatin is involved in non-malignant pituitary neoplasia by causing abnormal expression of tumor suppressors and oncogenes. These changes are potentially reversible, suggesting the possibility of targeting tumor cells by

Externí odkaz: https://doaj.org/article/a51b38507b564d47a8b6de4809019a77

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Akademický článek

The dynamics of human bone marrow adipose tissue in response to feeding and fasting

Autor: Pouneh K. Fazeli, Miriam A. Bredella, Gisela Pachon-Peña, Wenxiu Zhao, Xun Zhang, Alexander T. Faje, Megi Resulaj, Sai P. Polineni, Tara M. Holmes, Hang Lee, Elizabeth K. O’Donnell, Ormond A. MacDougald, Mark C. Horowitz, Clifford J. Rosen, Anne Klibanski

Publikováno v: JCI Insight, Vol 6, Iss 12 (2021)

BACKGROUND Adipocytes were long considered inert components of the bone marrow niche, but mouse and human models suggest bone marrow adipose tissue (BMAT) is dynamic and responsive to hormonal and nutrient cues.METHODS In this study of healthy volunt

Externí odkaz: https://doaj.org/article/f9b9b856c1e14301bb81e9b24e87630a

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Akademický článek

Physiologic Transdermal Estradiol Replacement Mimics Effects of Endogenous Estrogen on Bone Outcomes in Hypoestrogenic Women with Anorexia Nervosa

Autor: Vibha Singhal, Supritha Nimmala, Meghan Slattery, Kamryn T. Eddy, Karen K. Miller, Anne Klibanski, Madhusmita Misra

Publikováno v: Nutrients, Vol 14, Iss 13, p 2557 (2022)

Background: While physiologic estrogen replacement results in increases in areal bone mineral density (aBMD) in hypoestrogenic adolescent girls and young adult women with AN, data are lacking regarding its impact on measures of volumetric BMD (vBMD),

Externí odkaz: https://doaj.org/article/350324bf540b40c1afc5f20b04d1fa54

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Akademický článek

Modulation of neural fMRI responses to visual food cues by overeating and fasting interventions: A preliminary study

Autor: Liya Kerem, Laura Holsen, Pouneh Fazeli, Miriam A. Bredella, Christopher Mancuso, Megi Resulaj, Tara M. Holmes, Anne Klibanski, Elizabeth A. Lawson

Publikováno v: Physiological Reports, Vol 8, Iss 24, Pp n/a-n/a (2021)

Abstract Neural processing of visual food stimuli is perturbated at extremes of weight. Human fMRI studies investigating diet effects on neural processing of food cues could aid in understanding altered brain activation in conditions of under‐ and

Externí odkaz: https://doaj.org/article/1508ae247a5f4d62a57576ac2c577854

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Akademický článek

Two Synchronous Pituitary Adenomas Causing Cushing Disease and Acromegaly

Autor: Melanie Schorr, MD, Xun Zhang, PhD, Wenxiu Zhao, PhD, Parisa Abedi, MD, Kate E. Lines, PhD, Essa Te Hedley-Whyte, MD, Brooke Swearingen, MD, Anne Klibanski, MD, Karen K. Miller, MD, Rajesh V. Thakker, MD, FRS, Lisa B. Nachtigall, MD

Publikováno v: AACE Clinical Case Reports, Vol 5, Iss 5, Pp e276-e281 (2019)

ABSTRACT: Objective: To report the first case of 2 synchronous pituitary adenomas, 1 corticotroph and 1 somatotroph, with distinct molecular lineages confirmed by differential hormone and S-100 protein expression. Methods: A case report followed by a

Externí odkaz: https://doaj.org/article/74131b701c514b6ca37dc79711dd4abd

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Akademický článek

Plasma midkine concentrations in healthy children, children with increased and decreased adiposity, and children with short stature.

Autor: Youn Hee Jee, Kun Song Lee, Shanna Yue, Ellen W Leschek, Matthew G Boden, Aysha Jadra, Anne Klibanski, Priya Vaidyanathan, Madhusmita Misra, Young Pyo Chang, Jack A Yanovski, Jeffrey Baron

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0224103 (2019)

BackgroundMidkine (MDK), one of the heparin-binding growth factors, is highly expressed in multiple organs during embryogenesis. Plasma concentrations have been reported to be elevated in patients with a variety of malignancies, in adults with obesit

Externí odkaz: https://doaj.org/article/c87f0e6742294c75bb6515e874067e1f

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