Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Anne, Heikkinen"'
Autor:
Riitta Kaarteenaho, Oula Norman, Jarkko Koivunen, Antti M Salo, Joni M Mäki, Johanna Myllyharju, Taina Pihlajaniemi, Anne Heikkinen
Publikováno v:
BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)
Background Collagen XIII is a transmembrane collagen associated with neuromuscular junction development, and in humans its deficiency results in congenital myasthenic syndrome type 19 (CMS19), which leads to breathing difficulties. CMS19 patients usu
Externí odkaz:
https://doaj.org/article/ac36a204554a4f418330e724704750ba
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0276215 (2022)
Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with a poor prognosis and few treatment options. In the most widely used experimental model for this disease, bleomycin is administered into the lungs of mice, causing a reaction of inflamm
Externí odkaz:
https://doaj.org/article/53ad385b25ea4a57afa6042d55f2ba6a
Autor:
Tomáš Zárybnický, Anne Heikkinen, Salla M. Kangas, Marika Karikoski, Guillermo Antonio Martínez-Nieto, Miia H. Salo, Johanna Uusimaa, Reetta Vuolteenaho, Reetta Hinttala, Petra Sipilä, Satu Kuure
Publikováno v:
Cells, Vol 10, Iss 11, p 3158 (2021)
The modification of genes in animal models has evidently and comprehensively improved our knowledge on proteins and signaling pathways in human physiology and pathology. In this review, we discuss almost 40 monogenic rare diseases that are enriched i
Externí odkaz:
https://doaj.org/article/51145108edac43eaa2eb4993dd172c41
Autor:
Guillermo Martínez-Nieto, Ritva Heljasvaara, Anne Heikkinen, Hanne-Kaisa Kaski, Raman Devarajan, Otto Rinne, Charlotta Henriksson, Emmi Thomson, Camilla von Hertzen, Ilkka Miinalainen, Heli Ruotsalainen, Taina Pihlajaniemi, Sanna-Maria Karppinen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9978 (2021)
Basement membrane (BM) zone-associated collagen XV (ColXV) has been shown to suppress the malignancy of tumour cells, and its restin domain can inhibit angiogenesis. In human breast cancer, as well as in many other human carcinomas, ColXV is lost fro
Externí odkaz:
https://doaj.org/article/ed07102488da46b6bfacad73bf12acf6
Autor:
Mahsima Khoshneviszadeh, Solveig Jandke, Lorena Morton, Rahul Kaushik, Philipp Arndt, Oula Norman, Jari Jukkola, Ildiko Rita Dunay, Constanze Seidenbecher, Anne Heikkinen, Stefanie Schreiber, Alexander Dityatev
Collagen XVIII (COL18A1) is an abundant heparan sulfate proteoglycan in vascular basement membranes. Here, we asked (i) if the loss of collagen XVIII would result in blood-brain barrier (BBB) breakdown, pathological alterations of small arteries and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be284a7998f890c4cabcb4ee197716ff
https://doi.org/10.21203/rs.3.rs-1980968/v2
https://doi.org/10.21203/rs.3.rs-1980968/v2
Autor:
Lauri Eklund, Harri Elamaa, Taina Pihlajaniemi, Lloyd Ruddock, Gong-Hong Wei, Qin Zhang, Mohammadhassan Ansarizadeh, Anna Laitakari, Ilkka Miinalainen, Raman Devarajan, Anne Heikkinen, Hongmin Tu, Veli-Pekka Ronkainen, Mika Kaakinen, Riikka Pietilä, Minna K. Kihlström, Emmi Kapiainen
Visualization of basal cell surface of ANGPT2-GFP HUVECs during cell spreading.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cec62beb0505fbc1725b2ab10c1d54c
https://doi.org/10.1158/0008-5472.22426509
https://doi.org/10.1158/0008-5472.22426509
Autor:
Lauri Eklund, Harri Elamaa, Taina Pihlajaniemi, Lloyd Ruddock, Gong-Hong Wei, Qin Zhang, Mohammadhassan Ansarizadeh, Anna Laitakari, Ilkka Miinalainen, Raman Devarajan, Anne Heikkinen, Hongmin Tu, Veli-Pekka Ronkainen, Mika Kaakinen, Riikka Pietilä, Minna K. Kihlström, Emmi Kapiainen
Supplementary Figure S1: Amino acid sequence of ANGPT2, ANGPT2443 and ANGTPT2DAP. Supplementary Figure S2: Competitive inhibition of ANGPT4-induced TIE2 phosphorylation by ANGPT2 isoforms. Supplementary Figure S3. TIE2 phosphorylation by ANGPT2 isofo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48eb29cab98bf33eb845539dd7992c3f
https://doi.org/10.1158/0008-5472.22426518
https://doi.org/10.1158/0008-5472.22426518
Autor:
Lauri Eklund, Harri Elamaa, Taina Pihlajaniemi, Lloyd Ruddock, Gong-Hong Wei, Qin Zhang, Mohammadhassan Ansarizadeh, Anna Laitakari, Ilkka Miinalainen, Raman Devarajan, Anne Heikkinen, Hongmin Tu, Veli-Pekka Ronkainen, Mika Kaakinen, Riikka Pietilä, Minna K. Kihlström, Emmi Kapiainen
Angiopoietin-2 (ANGPT2) is a context-dependent TIE2 agonistic or antagonistic ligand that induces diverse responses in cancer. Blocking ANGPT2 provides a promising strategy for inhibiting tumor growth and metastasis, yet variable effects of targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11b00faa0ce8b7dc41393cd27efe7e1
https://doi.org/10.1158/0008-5472.c.6512358.v1
https://doi.org/10.1158/0008-5472.c.6512358.v1
Autor:
Lauri Eklund, Harri Elamaa, Taina Pihlajaniemi, Lloyd Ruddock, Gong-Hong Wei, Qin Zhang, Mohammadhassan Ansarizadeh, Anna Laitakari, Ilkka Miinalainen, Raman Devarajan, Anne Heikkinen, Hongmin Tu, Veli-Pekka Ronkainen, Mika Kaakinen, Riikka Pietilä, Minna K. Kihlström, Emmi Kapiainen
Supplementary Tables I-III
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae0bf93ba1985d4c50d2f82803fd8c3
https://doi.org/10.1158/0008-5472.22426506
https://doi.org/10.1158/0008-5472.22426506
Autor:
Lauri Eklund, Harri Elamaa, Taina Pihlajaniemi, Lloyd Ruddock, Gong-Hong Wei, Qin Zhang, Mohammadhassan Ansarizadeh, Anna Laitakari, Ilkka Miinalainen, Raman Devarajan, Anne Heikkinen, Hongmin Tu, Veli-Pekka Ronkainen, Mika Kaakinen, Riikka Pietilä, Minna K. Kihlström, Emmi Kapiainen
Visualization of basal cell surface of GFP-HUVECs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2911e042eb3215c349ed283cdd0e0f
https://doi.org/10.1158/0008-5472.22426512
https://doi.org/10.1158/0008-5472.22426512