Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Anne, Ephrussi"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract In response to nutritional stress, microtubules in cells of the Drosophila female germline are depleted from the cytoplasm and accumulate cortically. This triggers aggregation of mRNPs into large processing bodies (P-bodies) and oogenesis ar
Externí odkaz:
https://doaj.org/article/b883418307a149cab2d3c3ec7950216f
Autor:
Lucia Cassella, Anne Ephrussi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
In this study the authors identify localized RNAs in the Drosophila follicular epithelium by spatial transcriptomics and through genetic analyses determine canonical and translation-based mechanisms underlying basal and apical RNA localization.
Externí odkaz:
https://doaj.org/article/d4dba8db7e7045859e735dc46594d90e
Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains
Autor:
Simone Heber, Imre Gáspár, Jan-Niklas Tants, Johannes Günther, Sandra M. Fernandez Moya, Robert Janowski, Anne Ephrussi, Michael Sattler, Dierk Niessing
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The Staufen family of RNA-binding proteins are conserved microtubule dependent mRNA transporter factors. Here the authors use biochemical and functional approaches to characterize the RNA-binding properties of mouse Staufen 2 and study the mRNA bindi
Externí odkaz:
https://doaj.org/article/29fa2d6445dc46718928f19f8f73daa7
Publikováno v:
Journal of Cell Biology. 222
Regulated recruitment and activity of motor proteins is essential for intracellular transport of cargoes, including messenger ribonucleoprotein complexes (RNPs). Here we show that orchestration ofoskarRNP transport in theDrosophilagermline relies on
Publikováno v:
Cell Reports, Vol 28, Iss 5, Pp 1219-1236.e11 (2019)
Summary: Exon junction complex (EJC) assembles after splicing at specific positions upstream of exon-exon junctions in mRNAs of all higher eukaryotes, affecting major regulatory events. In mammalian cell cytoplasm, EJC is essential for efficient RNA
Externí odkaz:
https://doaj.org/article/cb5fd0009d9d456180c3ee1873d1c07b
Autor:
Vasiliy O. Sysoev, Bernd Fischer, Christian K. Frese, Ishaan Gupta, Jeroen Krijgsveld, Matthias W. Hentze, Alfredo Castello, Anne Ephrussi
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Early development is controlled by maternally deposited mRNAs and the RNA-binding proteins (RBPs) that regulate them. Here the authors describe the identification of a large number of RBPs bound to polyadenylated RNAs in Drosophilaembryos before and
Externí odkaz:
https://doaj.org/article/2fbe552daba04c8d8a620555ac971d55
Publikováno v:
Bio-Protocol, Vol 8, Iss 5 (2018)
Arrays of short, singly-labeled ssDNA oligonucleotides enable in situ hybridization with single molecule sensitivity and efficient transcript specific RNA capture. Here, we describe a simple, enzymatic protocol that can be carried out using basic lab
Externí odkaz:
https://doaj.org/article/dd1f13063ac34adca2dabecb0c2ab6a3
Autor:
Mandy Jeske, Matteo Bordi, Sebastian Glatt, Sandra Müller, Vladimir Rybin, Christoph W. Müller, Anne Ephrussi
Publikováno v:
Cell Reports, Vol 12, Iss 4, Pp 587-598 (2015)
In many animals, the germ plasm segregates germline from soma during early development. Oskar protein is known for its ability to induce germ plasm formation and germ cells in Drosophila. However, the molecular basis of germ plasm formation remains u
Externí odkaz:
https://doaj.org/article/49796906f431473ea5e6f5b5580368ae
Autor:
Anne Ephrussi, Lucia Cassella
Publikováno v:
Nature Communications. 13
Intracellular RNA localization is a widespread and dynamic phenomenon that compartmentalizes gene expression and contributes to the functional polarization of cells. Thus far, mechanisms of RNA localization identified in Drosophila have been based on