Development and Validation of Four Different Methods to Improve MRI-CEST Tumor pH Mapping in Presence of Fat

Autor: Francesco Gammaraccio, Daisy Villano, Pietro Irrera, Annasofia A. Anemone, Antonella Carella, Alessia Corrado, Dario Livio Longo

Publikováno v: Journal of Imaging, Vol 10, Iss 7, p 166 (2024)

CEST-MRI is an emerging imaging technique suitable for various in vivo applications, including the quantification of tumor acidosis. Traditionally, CEST contrast is calculated by asymmetry analysis, but the presence of fat signals leads to wrong cont

Externí odkaz: https://doaj.org/article/fefab3135d4c4c7d99c391def4a13175

Effect of Esomeprazole Treatment on Extracellular Tumor pH in a Preclinical Model of Prostate Cancer by MRI-CEST Tumor pH Imaging.

Autor: Irrera P; Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', 81100 Caserta, Italy.; Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR), 10126 Turin, Italy., Roberto M; Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy., Consolino L; Department of Nanomedicines and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University, 52074 Aachen, Germany., Anemone A; Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy., Villano D; Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy., Navarro-Tableros V; Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy., Carella A; Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR), 10126 Turin, Italy., Dastrù W; Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy., Aime S; IRCCS SDN SynLab, 80143 Naples, Italy., Longo DL; Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR), 10126 Turin, Italy.

Publikováno v: Metabolites [Metabolites] 2022 Dec 28; Vol. 13 (1). Date of Electronic Publication: 2022 Dec 28.

In Vivo MRI-CEST Tumor pH Imaging Detects Resistance to Proton Pump Inhibitors in Human Prostate Cancer Murine Models.

Autor: Irrera P; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania 'Luigi Vanvitelli', 81100 Caserta, Italy.; Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR), 10126 Turin, Italy., Consolino L; Department of Nanomedicines and Theranostics, Institute for Experimental Molecular Imaging, RWTH Aachen University, 52074 Aachen, Germany., Roberto M; Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Turin, Italy., Capozza M; Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Turin, Italy., Dhakan C; Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR), 10126 Turin, Italy., Carella A; Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR), 10126 Turin, Italy., Corrado A; Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR), 10126 Turin, Italy., Villano D; Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Turin, Italy., Anemone A; Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Turin, Italy., Navarro-Tableros V; Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Turin, Italy., Bracesco M; Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Turin, Italy., Dastrù W; Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Turin, Italy., Aime S; IRCCS SDN SynLab, 80143 Naples, Italy., Longo DL; Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR), 10126 Turin, Italy.

Publikováno v: Cancers [Cancers (Basel)] 2022 Oct 07; Vol. 14 (19). Date of Electronic Publication: 2022 Oct 07.

What do we know about dynamic glucose-enhanced (DGE) MRI and how close is it to the clinics? Horizon 2020 GLINT consortium report.

Autor: Kim M; Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.; Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK., Eleftheriou A; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Ravotto L; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Weber B; Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.; Neuroscience Center Zurich, Zurich, Switzerland., Rivlin M; School of Chemistry, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel., Navon G; School of Chemistry, Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel., Capozza M; Molecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy., Anemone A; Molecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy., Longo DL; Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR), Torino, Italy., Aime S; Molecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy., Zaiss M; Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.; Neuroradiology, University Clinic Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany., Herz K; Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.; Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany., Deshmane A; Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.; Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany., Lindig T; Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.; Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany., Bender B; Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany., Golay X; Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK. x.golay@ucl.ac.uk.

Publikováno v: Magma (New York, N.Y.) [MAGMA] 2022 Feb; Vol. 35 (1), pp. 87-104. Date of Electronic Publication: 2022 Jan 15.

Investigating plasma volume expanders as novel macromolecular MRI-CEST contrast agents for tumor contrast-enhanced imaging.

Autor: Consolino L; Molecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy., Irrera P; Molecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy.; University of Campania Luigi Vanvitelli, Caserta, Italy., Romdhane F; Molecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy., Anemone A; Molecular Imaging Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy., Longo DL; Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR), Turin, Italy.

Publikováno v: Magnetic resonance in medicine [Magn Reson Med] 2021 Aug; Vol. 86 (2), pp. 995-1007. Date of Electronic Publication: 2021 Mar 25.