Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Annarita Fiorillo"'
Autor:
Annarita Fiorillo, Gianni Colotti, Cécile Exertier, Anastasia Liuzzi, Francesca Seghetti, Alessandra Salerno, Jessica Caciolla, Andrea Ilari
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Trypanothione reductase (TR) is a key factor in the redox homeostasis of trypanosomatid parasites, critical for survival in the hostile oxidative environment generated by the host to fight infection. TR is considered an attractive target for the deve
Externí odkaz:
https://doaj.org/article/4b2828d0298b44f59cd154685afc2200
Autor:
Lorenzo Turcano, Theo Battista, Esther Torrente De Haro, Antonino Missineo, Cristina Alli, Giacomo Paonessa, Gianni Colotti, Steven Harper, Annarita Fiorillo, Andrea Ilari, Alberto Bresciani
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0008339 (2020)
Trypanothione reductase (TR) is a key enzyme that catalyzes the reduction of trypanothione, an antioxidant dithiol that protects Trypanosomatid parasites from oxidative stress induced by mammalian host defense systems. TR is considered an attractive
Externí odkaz:
https://doaj.org/article/6fee285090df47ca90b7a67167e262d5
Autor:
Gianluca Marucci, Ilaria Zullino, Lucia Bertuccini, Serena Camerini, Serena Cecchetti, Agostina Pietrantoni, Marialuisa Casella, Paolo Vatta, Alex D. Greenwood, Annarita Fiorillo, Marco Lalle
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 654 (2021)
Giardiasis, caused by the protozoan parasite Giardia duodenalis, is an intestinal diarrheal disease affecting almost one billion people worldwide. A small endosymbiotic dsRNA viruses, G. lamblia virus (GLV), genus Giardiavirus, family Totiviridae, mi
Externí odkaz:
https://doaj.org/article/56bd812df1bc45699f21ce4485b6424d
Autor:
Francesco Saccoliti, Gabriella Angiulli, Giovanni Pupo, Luca Pescatori, Valentina Noemi Madia, Antonella Messore, Gianni Colotti, Annarita Fiorillo, Luigi Scipione, Marina Gramiccia, Trentina Di Muccio, Roberto Di Santo, Roberta Costi, Andrea Ilari
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 304-310 (2017)
The study presented here aimed at identifying a new class of compounds acting against Leishmania parasites, the causative agent of Leishmaniasis. For this purpose, the thioether derivatives of our in-house library have been evaluated in whole-cell sc
Externí odkaz:
https://doaj.org/article/de179a5ef75d46f89e1509c610471976
Publikováno v:
Molecules, Vol 25, Iss 8, p 1924 (2020)
The protozoans Leishmania and Trypanosoma, belonging to the same Trypanosomatidae family, are the causative agents of Leishmaniasis, Chagas disease, and human African trypanosomiasis. Overall, these infections affect millions of people worldwide, pos
Externí odkaz:
https://doaj.org/article/ab135e413f5a4170a9b46e62a3569713
Autor:
Lorenzo Turcano, Esther Torrente, Antonino Missineo, Matteo Andreini, Marina Gramiccia, Trentina Di Muccio, Ilaria Genovese, Annarita Fiorillo, Steven Harper, Alberto Bresciani, Gianni Colotti, Andrea Ilari
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006969 (2018)
Trypanothione reductase (TR) is considered to be one of the best targets to find new drugs against Leishmaniasis. This enzyme is fundamental for parasite survival in the host since it reduces trypanothione, a molecule used by the tryparedoxin/trypare
Externí odkaz:
https://doaj.org/article/af5f06d4d9594ea4b914709906958f7d
Autor:
Annarita Fiorillo, Maria Petrosino, Andrea Ilari, Alessandra Pasquo, Alessandra Cipollone, Maristella Maggi, Roberta Chiaraluce, Valerio Consalvi
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199191 (2018)
Cancer cells are able to survive in difficult conditions, reprogramming their metabolism according to their requirements. Under hypoxic conditions they shift from oxidative phosphorylation to aerobic glycolysis, a behavior known as Warburg effect. In
Externí odkaz:
https://doaj.org/article/aea6a3fc775d4c81a31610ead4b83318
Autor:
Gianni Colotti, Elena Poser, Annarita Fiorillo, Ilaria Genovese, Valerio Chiarini, Andrea Ilari
Publikováno v:
Molecules, Vol 19, Iss 9, Pp 13976-13989 (2014)
Sorcin is a penta-EF hand calcium binding protein, which participates in the regulation of calcium homeostasis in cells. Sorcin regulates calcium channels and exchangers located at the plasma membrane and at the endo/sarcoplasmic reticulum (ER/SR), a
Externí odkaz:
https://doaj.org/article/fd489642144849a792d604d48d07f37d
Autor:
Annarita Fiorillo, Daniele di Marino, Lucia Bertuccini, Allegra Via, Edoardo Pozio, Serena Camerini, Andrea Ilari, Marco Lalle
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92902 (2014)
The 14-3-3s are a family of dimeric evolutionary conserved pSer/pThr binding proteins that play a key role in multiple biological processes by interacting with a plethora of client proteins. Giardia duodenalis is a flagellated protozoan that affects
Externí odkaz:
https://doaj.org/article/1660277606a540a3a4665829aebb2a6a
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 8, p e1781 (2012)
Leishmaniasis is a neglected disease caused by Leishmania, an intracellular protozoan parasite which possesses a unique thiol metabolism based on trypanothione. Trypanothione is used as a source of electrons by the tryparedoxin/tryparedoxin peroxidas
Externí odkaz:
https://doaj.org/article/08eab9c3e41946f38fc6358e14fe6746