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of 4
pro vyhledávání: '"Annanya Shetty"'
Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption
Autor:
Annanya Shetty, Zhujun Xu, Umayal Lakshmanan, Jeffrey Hill, Meng Ling Choong, Shu-Sin Chng, Yoshiyuki Yamada, Anders Poulsen, Thomas Dick, Martin Gengenbacher
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
To identify novel inhibitors of Mycobacterium tuberculosis cell envelope biosynthesis, we employed a two-step approach. First, we screened the diverse synthetic small molecule 71,544-compound Enamine library for growth inhibitors using the non-pathog
Externí odkaz:
https://doaj.org/article/cb21df1d8aed41e0b481a951ca909fec
Autor:
Annanya Shetty, Thomas Dick
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Mycobacterial cell wall inhibitors interfere with targets involved in synthesis of mycolic acids, arabinogalactan and peptidoglycan. These antibiotics corrupt structural integrity of the cell envelope and this is believed to be the cause of drug medi
Externí odkaz:
https://doaj.org/article/da763556080e48a796ddce7190732a60
Publikováno v:
Pharmacological research. 158
Over the last two decades, developments in nanomedicine have resulted in technical advances with application to clinical science. Both organic and inorganic nanoparticles (NPs) have shown tolerability, pharmacologic specificity and biodegradability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f1cf08c63bf974b22f837a2627ca510
https://pubmed.ncbi.nlm.nih.gov/32097749
https://pubmed.ncbi.nlm.nih.gov/32097749
Autor:
Thomas Dick, Véronique Dartois, Susana Gardete, Robert S. Jansen, Annanya Shetty, Kyu Y. Rhee, Chao Chen
Publikováno v:
Antimicrobial Agents and Chemotherapy
Mycobacterium tuberculosis kills more people than any other bacterial pathogen and is becoming increasingly untreatable due to the emergence of resistance. Verapamil, an FDA-approved calcium channel blocker, potentiates the effect of several antitube
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b3b2931a906a5791c6b838f8ee68f7
http://europepmc.org/articles/PMC5923092
http://europepmc.org/articles/PMC5923092