Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Annamaria Tonazzi"'
Autor:
Lara Console, Mariafrancesca Scalise, Simona Salerno, Raffaella Scanga, Deborah Giudice, Loredana De Bartolo, Annamaria Tonazzi, Cesare Indiveri
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The type II glycoprotein CD98 (SLC3A2) is a membrane protein with pleiotropic roles in cells, ranging from modulation of inflammatory processes, host–pathogen interactions to association with membrane transporters of the SLC7 family. The r
Externí odkaz:
https://doaj.org/article/e8d45fdc35c54356b895f6c4a0255354
Autor:
Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Mariafrancesca Scalise, Cesare Indiveri
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 993 (2023)
Background: The carnitine/acylcarnitine carrier (CAC) represents the route of delivering acyl moieties to the mitochondrial matrix for accomplishing the fatty acid β-oxidation. The CAC has a couple of Cys residues (C136 and C155) most reactive towar
Externí odkaz:
https://doaj.org/article/1dc385f58e5e44e6be3206c615aeee11
Autor:
Nicola Giangregorio, Annamaria Tonazzi, Cosima Damiana Calvano, Ciro Leonardo Pierri, Giovanna Incampo, Tommaso R. I. Cataldi, Cesare Indiveri
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2228 (2023)
The effect of mycotoxin patulin (4-hydroxy-4H-furo [3,2c] pyran-2 [6H] -one) on the mitochondrial carnitine/acylcarnitine carrier (CAC, SLC25A20) was investigated. Transport function was measured as [3H]-carnitineex/carnitinein antiport in proteolipo
Externí odkaz:
https://doaj.org/article/e0a306d27a4742df98c83de7136e0dd9
Autor:
Lara Console, Mariafrancesca Scalise, Tiziano Mazza, Lorena Pochini, Michele Galluccio, Nicola Giangregorio, Annamaria Tonazzi, Cesare Indiveri
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Metabolic flexibility is a peculiar hallmark of cancer cells. A growing number of observations reveal that tumors can utilize a wide range of substrates to sustain cell survival and proliferation. The diversity of carbon sources is indicative of meta
Externí odkaz:
https://doaj.org/article/265e179e1e9040f5b413ed85e7271e67
Autor:
Lara Console, Mariafrancesca Scalise, Nicola Giangregorio, Annamaria Tonazzi, Maria Barile, Cesare Indiveri
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Renal proximal tubular cells are high energy-demanding cells mainly relying on fatty acid oxidation. In stress conditions, such as transient hypoxia, fatty acid oxidation (FAO) decreases and carbohydrate catabolism fails to compensate for the energy
Externí odkaz:
https://doaj.org/article/e739896a1ef74d6c96d71e5ccc849660
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 521 (2021)
The SLC25A20 transporter, also known as carnitine acyl-carnitine carrier (CAC), catalyzes the transport of short, medium and long carbon chain acyl-carnitines across the mitochondrial inner membrane in exchange for carnitine. The 30-year story of the
Externí odkaz:
https://doaj.org/article/96af68225e8a4324bc77c6991f8b28fb
Autor:
Nicola Giangregorio, Annamaria Tonazzi, Lara Console, Mario Prejanò, Tiziana Marino, Nino Russo, Cesare Indiveri
Publikováno v:
Molecules, Vol 25, Iss 4, p 820 (2020)
The effect of copper on the mitochondrial carnitine/acylcarnitine carrier (CAC) was studied. Transport function was assayed as [3H]carnitine/carnitine antiport in proteoliposomes reconstituted with the native protein extracted from rat liver mitochon
Externí odkaz:
https://doaj.org/article/4d8ed083d5b04326922601ea0e6a1f70
Autor:
Vito Scalera, Nicola Giangregorio, Silvana De Leonardis, Lara Console, Emanuele Salvatore Carulli, Annamaria Tonazzi
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
The Mitochondrial Ascorbic Acid Transporter (MAT) from both rat liver and potato mitochondria has been reconstituted in proteoliposomes. The protein has a molecular mass in the range of 28–35 kDa and catalyzes saturable, temperature and pH dependen
Externí odkaz:
https://doaj.org/article/acb317069d9c495d91b40a078608ab8c
Autor:
Annamaria Tonazzi, Mariafrancesca Scalise, Lorena Pochini, Nicola Giangregorio, Cesare Indiveri
Publikováno v:
Pharmaceutics, Vol 5, Iss 3, Pp 472-497 (2013)
Proteoliposomes represent a suitable and up to date tool for studying membrane transporters which physiologically mediate absorption, excretion, trafficking and reabsorption of nutrients and metabolites. Using recently developed reconstitution strate
Externí odkaz:
https://doaj.org/article/2ceb6950cd894850b65c7259816e0601
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82286 (2013)
The effect of omeprazole on the mitochondrial carnitine/acylcarnitine transporter has been studied in proteoliposomes. Externally added omeprazole inhibited the carnitine/carnitine antiport catalysed by the transporter. The inhibition was partially r
Externí odkaz:
https://doaj.org/article/f3fca61ac31e4bd3ba192a4d944cdee4