Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Annamaria Fra"'
Autor:
Serena Calamaio, Marialaura Serzanti, Jennifer Boniotti, Annamaria Fra, Emirena Garrafa, Manuela Cominelli, Rosanna Verardi, Pietro Luigi Poliani, Silvia Dotti, Riccardo Villa, Giovanna Mazzoleni, Patrizia Dell’Era, Nathalie Steimberg
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2114 (2023)
The process of identifying and approving a new drug is a time-consuming and expensive procedure. One of the biggest issues to overcome is the risk of hepatotoxicity, which is one of the main reasons for drug withdrawal from the market. While animal m
Externí odkaz:
https://doaj.org/article/640c9574e0ce498ea754214807f908c0
Autor:
Mattia Laffranchi, Emma L K Elliston, Fabrizio Gangemi, Romina Berardelli, David A Lomas, James A Irving, Annamaria Fra
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0206955 (2019)
Lung disease in alpha-1-antitrypsin deficiency (AATD) results from dysregulated proteolytic activity, mainly by neutrophil elastase (HNE), in the lung parenchyma. This is the result of a substantial reduction of circulating alpha-1-antitrypsin (AAT)
Externí odkaz:
https://doaj.org/article/c8121f93c20f4dad858c69d37a68aaf1
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Thiol groups can undergo numerous modifications, making cysteine a unique molecular switch. Cysteine plays structural and regulatory roles as part of proteins or glutathione, contributing to maintain redox homeostasis and regulate signaling within an
Externí odkaz:
https://doaj.org/article/40210a5cd6e943e7a4a8d749a7203b67
Autor:
Stefano Ricagno, Cristina Visentin, Annamaria Fra, Elena Miranda, Giovanna Galliciotti, Emanuela D'Acunto, Mauro Manno
Publikováno v:
Cellular and Molecular Life Sciences
Neuroserpin is a serine protease inhibitor identified in a search for proteins implicated in neuronal axon growth and synapse formation. Since its discovery over 30 years ago, it has been the focus of active research. Many efforts have concentrated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6382d243b484afe7fed702f441be0df1
https://doi.org/10.1007/s00018-021-03907-6
https://doi.org/10.1007/s00018-021-03907-6
Autor:
James A. Irving, Annamaria Fra, Stefania Ottaviani, David A. Lomas, Alice Maria Balderacchi, Emanuela D'Acunto, Elena Miranda, Riccardo Ronzoni, Ilaria Ferrarotti
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5668, p 5668 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences
Volume 22
Issue 11
Alpha-1-antitrypsin (AAT) deficiency causes pulmonary disease due to decreased levels of circulating AAT and consequently unbalanced protease activity in the lungs. Deposition of specific AAT variants, such as the common Z AAT, within hepatocytes may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef1e8f11d73bab7b948810534daf6eb
http://hdl.handle.net/11379/545282
http://hdl.handle.net/11379/545282
Autor:
Riccardo, Ronzoni, Nina, Heyer-Chauhan, Annamaria, Fra, Andrew C, Pearce, Martin, Rüdiger, Elena, Miranda, James A, Irving, David A, Lomas
Publikováno v:
The Febs Journal
The formation of ordered Z α1‐antitrypsin polymers is central to liver disease in α1‐antitrypsin deficiency. The nascent α1‐antitrypsin folds via the M* intermediate to native monomer or becomes incorporated into a soluble polymer that can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c7d9afdd3b711bf810f84e1ff71d82a
https://pubmed.ncbi.nlm.nih.gov/33058391
https://pubmed.ncbi.nlm.nih.gov/33058391
Autor:
Riccardo Ronzoni, Nina Heyer-Chauhan, Elena Miranda, David A. Lomas, James A. Irving, Mattia Laffranchi, Annamaria Fra, Juan Pérez, Emma L. K. Elliston, Mark L. Brantly, Alistair M. Jagger
Publikováno v:
'JCI Insight ', vol: 5, pages: 135459-1-135459-15 (2020)
JCI Insight
JCI Insight
The α-1-antitrypsin (or alpha-1-antitrypsin, A1AT) Z variant is the primary cause of severe A1AT deficiency and forms polymeric chains that aggregate in the endoplasmic reticulum of hepatocytes. Around 2%–5% of Europeans are heterozygous for the Z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b198a68a95ec42c2c4efdadf8c63b187
http://hdl.handle.net/11379/532194
http://hdl.handle.net/11379/532194
Autor:
M. Fuoti, Laura Pini, F. Benini, Francesca Cettolo, Manuela Ciarfaglia, Jordan Franz Giordani, Claudio Tantucci, Silvia Uccelli, Chiara Rocchetti, Annamaria Fra, Marianna Arici, Nicla Orzes, Mattia Laffranchi, Guido Levi, Luciano Corda
Publikováno v:
Chest. 157:A177
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e36778388b4dd5057821e4707bc9df8
https://doi.org/10.1016/j.chest.2020.05.199
https://doi.org/10.1016/j.chest.2020.05.199
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1826
Our current knowledge about the cellular mechanisms underlying serpin-related disorders, the serpinopathies, is predominantly based on studies in cell culture models of disease, particularly for alpha-1 antitrypsin (AAT, SERPINA1) deficiency causing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7fc5ee84f0b4ad3e4d6c7488d546f20f
https://pubmed.ncbi.nlm.nih.gov/30194596
https://pubmed.ncbi.nlm.nih.gov/30194596
Autor:
Romina Berardelli, Annamaria Fra, Ilaria Ferrarotti, Viola Ravasio, Mattia Laffranchi, Bibek Gooptu, Giuseppe Borsani, Edoardo Giacopuzzi
Publikováno v:
Human mutation. 39(9)
The growth of publicly available data informing upon genetic variations, mechanisms of disease, and disease subphenotypes offers great potential for personalized medicine. Computational approaches are likely required to assess a large number of novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66863f970727402927f39a9c8e1335e0
https://pubmed.ncbi.nlm.nih.gov/29882371
https://pubmed.ncbi.nlm.nih.gov/29882371