Výsledky vyhledávání - "Annamaria Bonelli"

200 BERBERINE ASSOCIATED TO DAPAGLIFLOZIN SYNERGISTICALLY REDUCES CARDIAC CELL APOPTOSIS DURING EXPOSURE TO TRASTUZUMAB THROUGH INDUCTION OF PAMPK AND RECUTION OF NLRP3, IL6 AND LEUKOTRIENES LEVELS

Autor: Vincenzo Quagliariello, Andrea Paccone, Claudia Saviano, Fabrizio Maurea, Simona Buccolo, Annamaria Bonelli, Gabriele Conforti, Antonietta Caronna, Nicola Maurea

Publikováno v: European Heart Journal Supplements. 24

Background Trastuzumab has improved the prognosis in patients with HER2-positive breast cancer, but it can induce left ventricular dysfunction with reduced ejection fraction or HF during treatment. Dapagliflozin is a SGLT2i with cardio-renal benefits

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46f9429fbfe10413d64293854d5dc6f2
https://doi.org/10.1093/eurheartjsupp/suac121.132

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205 SGLT-2 INHIBITOR DAPAGLIFLOZIN REDUCES ANTHRACYCLINE-MEDIATED CARDIOMYOPATHY IN PRECLINICAL MODELS THROUGH REDUCTION OF MYOCARDIAL NF-KB, MYD-88 AND NLRP3 EXPRESSION: A BIOCHEMICAL AND HISTOLOGICAL STUDY

Autor: Vincenzo Quagliariello, Simona Buccolo, Antonietta Caronna, Carlo Maurea, Andrea Paccone, Claudia Saviano, Annamaria Bonelli, Gabriele Conforti, Nicola Maurea

Publikováno v: European Heart Journal Supplements. 24

Background Doxorubicin-mediated adverse cardiovascular events are among the leading causes of morbidity and mortality in breast cancer patients. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have recently been shown to be of therapeutic value in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::768f8e6e334ccb81c2dad4f9ad50484f
https://doi.org/10.1093/eurheartjsupp/suac121.135

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206 LOW DOSES OF ADVANCED GLYCATION END PRODUCTS AND FRUCTOSILATION PRODUCTS PROMOTES PREMATURE CELL DEATH OF HUMAN CARDIAC CELLS AND INCREASES DRUG RESISTANCE OF HUMAN BREAST CANCER CELLS EXPOSED TO DOXORUBICIN THROUGH NLRP-3 AND MYD-88

Autor: Vincenzo Quagliariello, Fabrizio Maurea, Simona Buccolo, Antonietta Caronna, Andrea Paccone, Annamaria Bonelli, Gabriele Conforti, Claudia Saviano, Giuseppe D´aiuto, Nicola Maurea

Publikováno v: European Heart Journal Supplements. 24

Introduction Advanced glycosylation end-products (AGEs) are non-enzyme, protein glycosylation products caused by glucose-induced metabolic disorder, and play an important role in aging, cancer, metabolic syndrome and cardiovascular diseases. Purpose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed16f9b9ee06fcb93635da8bd8c880e7
https://doi.org/10.1093/eurheartjsupp/suac121.136

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Low doses of advanced glycation end-products and fructosilation products promotes premature cell death of human cardiac cells and increases drug resistance of human breast cancer cells exposed to doxorubicin through NLRP3 and MyD88 pathways

Autor: Vincenzo Quagliariello, Martina Iovine, Giuseppe D'Aiuto, Simona Buccolo, Carlo Maurea, Annamaria Bonelli, Andrea Paccone, Maria Laura Canale, Nicola Maurea

Publikováno v: Journal of Clinical Oncology. 40:e24055-e24055

e24055 Background: Advanced glycosylation end-products (AGEs) are non-enzyme, protein glycosylation products caused by glucose-induced metabolic disorder, and play an important role in aging, cancer, metabolic syndrome and cardiovascular diseases. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93554e762ac25cac92aed8c714ddded3
https://doi.org/10.1200/jco.2022.40.16_suppl.e24055

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Sacubitril-valsartan improves longitudinal strain and ejection fraction in preclinical models treated with anthracyclines through NLRP3, MyD88 pathways resulting in a reduction of myocardial IL-1β, IL-6, TNF-α and growth factors

Autor: Nicola Maurea, Martina Iovine, Simona Buccolo, Antonietta Caronna, Carlo Maurea, Annamaria Bonelli, Andrea Paccone, Irma Bisceglia, Maria Laura Canale, Vincenzo Quagliariello

Publikováno v: Journal of Clinical Oncology. 40:12063-12063

12063 Background: Doxorubicin-mediated adverse cardiovascular events are among the leading causes of morbidity and mortality in breast cancer patients. Sacubitril-valsartan (LCZ 696) is a combination drug, made up of neprilysin inhibitor sacubitril a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cdc7c259c0eb08d7f180c0d04283307a
https://doi.org/10.1200/jco.2022.40.16_suppl.12063

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The SGLT-2 Inhibitor Empagliflozin Improves Myocardial Strain, Reduces Cardiac Fibrosis and Pro-Inflammatory Cytokines in Non-Diabetic Mice Treated With Doxorubicin

Autor: Vincenzo Quagliariello, Michelino De Laurentiis, Domenica Rea, Antonio Barbieri, Maria Gaia Monti, Antonietta Caronna, Annamaria Bonelli, Gerardo Botti, Nicola Maurea

BackgroundEmpagliflozin (EMPA), a selective inhibitor of the sodium glucose co-transporter 2, reduced the risk of hospitalization for heart failure and cardiovascular death in type 2 diabetic patients in the EMPA‐REG OUTCOME trial. Other clinical t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a2009adb30718b9e666b4fb906df088
https://doi.org/10.21203/rs.3.rs-97968/v1

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Evidences of CTLA-4 and PD-1 Blocking Agents-Induced Cardiotoxicity in Cellular and Preclinical Models

Autor: Martina Iovine, Margherita Passariello, Annamaria Bonelli, Vincenzo Quagliariello, Antonietta Caronna, Nicola Maurea, Claudia De Lorenzo, Domenica Rea, Gerardo Botti, Antonio Barbieri

Publikováno v: Journal of Personalized Medicine, Vol 10, Iss 179, p 179 (2020)
Journal of Personalized Medicine
Volume 10
Issue 4

Background: Several strategies based on immune checkpoint inhibitors (ICIs) have been developed for cancer therapy, opening to advantages in cancer outcomes. However, several ICI-induced side effects have emerged in these patients, especially a rare

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e11fa077d5f0a1cb895fa2b9c14884a

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SARS-CoV-2 infection: NLRP3 inflammasome as plausible target to prevent cardiopulmonary complications?

Autor: Vincenzo Quagliariello, AnnaMaria Bonelli, Antonietta Caronna, Maria Cristina Lombari, Gabriele Conforti, Michele Libutti, Rosario Vincenzo Iaffaioli, Massimiliano Berretta, Gerardo Botti, Nicola Maurea

Publikováno v: European review for medical and pharmacological sciences. 24(17)

NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome has recently become an intriguing target of several chronic and viral diseases. Here, we argue that targeting NLRP3 inflammasome could be a strategy to prevent cardiovascular outco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc9c71a436d22b0c354c3361c32f637
https://pubmed.ncbi.nlm.nih.gov/32965010

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Nlrp3 as putative marker of ipilimumab-induced cardiotoxicity in the presence of hyperglycemia in estrogen-responsive and triple-negative breast cancer cells

Autor: Michelino De Laurentiis, Gerardo Botti, Giuseppina Rea, Vincenzo Quagliariello, Massimiliano Berretta, Antonietta Caronna, Maria Cristina Lombari, Annamaria Bonelli, Nicola Maurea, Stefania Cocco, Gabriele Conforti

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 7802, p 7802 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 20

Hyperglycemia, obesity and metabolic syndrome are negative prognostic factors in breast cancer patients. Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, achieving unprecedented efficacy in multiple malignancies. However, ICI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfadce38be590530d54c58c2638314f1
http://hdl.handle.net/11588/844155

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