Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation

Autor: Annamaria Antona, Giovanni Leo, Francesco Favero, Marco Varalda, Jacopo Venetucci, Stefania Faletti, Matilde Todaro, Eleonora Mazzucco, Enrica Soligo, Chiara Saglietti, Giorgio Stassi, Marcello Manfredi, Giuliana Pelicci, Davide Corà, Guido Valente, Daniela Capello

Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-16 (2023)

Abstract Among all cancers, colorectal cancer (CRC) is the 3rd most common and the 2nd leading cause of death worldwide. New therapeutic strategies are required to target cancer stem cells (CSCs), a subset of tumor cells highly resistant to present-d

Externí odkaz: https://doaj.org/article/1202d4f2902d4b05b7158dd3ec8eea0d

Extracellular vesicles from human plasma for biomarkers discovery: Impact of anticoagulants and isolation techniques.

Autor: Valentina Bettio, Eleonora Mazzucco, Annamaria Antona, Silvia Cracas, Marco Varalda, Jacopo Venetucci, Stefania Bruno, Giulia Chiabotto, Chiara Venegoni, Alessandra Vasile, Annalisa Chiocchetti, Marco Quaglia, Giovanni Camussi, Vincenzo Cantaluppi, Massimiliano Panella, Roberta Rolla, Marcello Manfredi, Daniela Capello

Publikováno v: PLoS ONE, Vol 18, Iss 5, p e0285440 (2023)

Extracellular vesicles (EVs) isolated from plasma are increasingly recognized as promising circulating biomarkers for disease discovery and progression, as well as for therapeutic drug delivery. The scientific community underlined the necessity of st

Externí odkaz: https://doaj.org/article/3c257377ca03488dba7bf6af618425aa

Psychotropic Drugs Show Anticancer Activity by Disrupting Mitochondrial and Lysosomal Function

Autor: Marco Varalda, Annamaria Antona, Valentina Bettio, Konkonika Roy, Ajay Vachamaram, Vaibhav Yellenki, Alberto Massarotti, Gianluca Baldanzi, Daniela Capello

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Background and Purpose: Drug repositioning is a promising strategy for discovering new therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their antitumor activity because of several epidemiological studies reporting low

Externí odkaz: https://doaj.org/article/fb2e7caceeb34b9ebc6c570b356edcc4

UPO Biobank: The Challenge of Integrating Biobanking into the Academic Environment to Support Translational Research

Autor: Valentina Bettio, Eleonora Mazzucco, Chiara Aleni, Silvia Cracas, Carmela Rinaldi, Annamaria Antona, Marco Varalda, Jacopo Venetucci, Daniela Ferrante, Antonio Rimedio, Daniela Capello

Publikováno v: Journal of Personalized Medicine. 13:911

Biobanks are driving motors of precision and personalized medicine by providing high-quality biological material/data through the standardization and harmonization of their collection, preservation, and distribution. UPO Biobank was established in 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20316cd83bcb620dbca57e6e8d358a41
https://doi.org/10.3390/jpm13060911

Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors

Autor: Daniela Capello, Maria Talmon, Andrea Graziani, L. Fresu, Alberto Massarotti, Alessandra Galetto, Gianluca Baldanzi, Suresh Velnati, Gian Cesare Tron, Alessandra Bertoni, Annamaria Antona, Valentina Mercalli

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 96-108 (2020)

A series of analogues of Amb639752, a novel diacylglycerol kinase (DGK) inhibitor recently discovered by us via virtual screening, have been tested. The compounds were evaluated as DGK inhibitors on α, θ, and ζ isoforms, and as antagonists on sero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f38fb4497308a8565ee9014cd0527ce