Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Annalisa Tait"'
Autor:
Chiara Borsari, Pasquale Linciano, Livio Brasili, Silvia Franchini, Nunzio Denora, Rosa Maria Iacobazzi, Claudia Sorbi, Annalisa Tait, Giulia Puja
Publikováno v:
ACS Med Chem Lett
[Image: see text] Sigma receptors (SRs) are recognized as valuable targets for the treatment of neurodegenerative disorders. A series of novel SRs ligands were designed by combining key pharmacophoric amines (i.e., benzylpiperidine or benzylpiperazin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33282d4b7cb22df367bbc59e3bfc3746
https://europepmc.org/articles/PMC7236556/
https://europepmc.org/articles/PMC7236556/
Publikováno v:
Journal of Medicinal Chemistry
After the first seed concept introduced in the 18th century, different disciplines have attributed different names to dual-functional molecules depending on their application, including bioconjugates, bifunctional compounds, multitargeting molecules,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80430477c25ee99d9e844a82f6d1a0f
https://pubmed.ncbi.nlm.nih.gov/32023055
https://pubmed.ncbi.nlm.nih.gov/32023055
In our previous work, spiroxatrine was taken as reference compound to develop selective NOP ligands. Therefore, several triazaspirodecanone derivatives were synthesized. Here, we verify their selectivity towards other 5-HT1 receptor subtypes and with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170cb7e62b188f7db115140564a2f41e
https://hdl.handle.net/11380/1207343
https://hdl.handle.net/11380/1207343
Autor:
Livio Brasili, Claudia Sorbi, Giuseppina Aricò, Umberto Maria Battisti, Paola Fossa, Elena Cichero, Rosa Maria Iacobazzi, Silvia Franchini, Annalisa Tait, Lorenza Pirona, Nunzio Denora, Simone Ronsisvalle, Leda Ivanova Bencheva, Antonio Cilia
Publikováno v:
Future Medicinal Chemistry. 10:2137-2154
Aim: Targeting 5-HT1A receptor (5-HT1AR) as a strategy for CNS disorders and pain control. Methodology: A series of 1,3-dioxolane-based 2-heteroaryl-phenoxyethylamines was synthesized by a convergent approach and evaluated at α1-adrenoceptors and 5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef6bff2b3a6c3af61d3c5ceaf60f041
https://doi.org/10.4155/fmc-2018-0107
https://doi.org/10.4155/fmc-2018-0107
Autor:
Paola Azzoni, Antonio Cilia, Umberto Maria Battisti, Claudia Sorbi, Cristina Magnoni, Luisa Benassi, Elena Cichero, Livio Brasili, Orazio Prezzavento, Cristina Vaschieri, Silvia Franchini, Leda Ivanova Bencheva, Simone Ronsisvalle, Annalisa Tait, Giuseppina Aricò, Paola Fossa
Publikováno v:
ChemMedChem. 12:1893-1905
A new series of spirocyclic σ receptor (σR) ligands were prepared and studied. Most were found to have a high affinity and selectivity for σ1 R; three compounds were shown to be σ1 R agonists, while another proved to be the only σ1 R antagonist.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9899a3c62f4a7ed9c72fe3b48d916aca
https://doi.org/10.1002/cmdc.201700427
https://doi.org/10.1002/cmdc.201700427
Publikováno v:
Pharmacological reports : PR. 72(2)
In our previous work, spiroxatrine was taken as reference compound to develop selective NOP ligands. Therefore, several triazaspirodecanone derivatives were synthesized. Here, we verify their selectivity towards other 5-HTBinding affinities were dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5a595a964cfe388fe7926971ce425bd
https://pubmed.ncbi.nlm.nih.gov/32002826
https://pubmed.ncbi.nlm.nih.gov/32002826
Autor:
Juan J. Torrado, Stefania Ferrari, Maria Paola Costi, Birte Behrens, Luca Costantino, Rosaria Luciani, Sara Macedo, Maria Kuzikov, María Jesús Corral, Anabela Cordeiro-da-Silva, Bernhard Ellinger, Chiara Borsari, Sheraz Gul, Ana Isabel Olías-Molero, María Dolores Jiménez-Antón, Jeanette Reinshagen, Nuno Santarém, José María Alunda, Annalisa Tait, Glauco Ponterini
Chemical modulation of the flavonol 2-(benzo[d][1,3]dioxol-5-yl)-chromen-4-one (1), a promising anti-Trypanosomatid agent previously identified, was evaluated through a phenotypic screening approach. Herein, we have performed structure–activity rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455b808d33574d4d1e3e13d9c8209afd
https://hdl.handle.net/11380/1175170
https://hdl.handle.net/11380/1175170
Autor:
Chiara Borsari, Maria Kuzikov, Catarina Baptista, Juan J. Torrado, Joachim Clos, Paloma Tejera Nevado, Maria Paola Costi, José María Alunda, Eugenia Bifeld, María Dolores Jiménez-Antón, Julia Eick, Caio Haddad Franco, Dorothea Zander-Dinse, Jeanette Reinshagen, Pasquale Linciano, Annalisa Tait, Nuno Santarém, María Jesús Corral, Gesa Witt, Luca Costantino, Glauco Ponterini, Rosaria Luciani, Anabela Cordeiro-da-Silva, Markus Wolf, Leda Severi, Carolina B. Moraes, Ana Isabel Olías-Molero, Sheraz Gul, Bernhard Ellinger, Stefania Ferrari
Leishmaniasis, a major health problem worldwide, has a limited arsenal of drugs for its control. The appearance of resistance to first- and second-line anti-leishmanial drugs confirms the need to develop new and less toxic drugs that overcome spontan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b38f72f55d16bf830aa39813bbeeb1
https://publica.fraunhofer.de/handle/publica/262302
https://publica.fraunhofer.de/handle/publica/262302
Autor:
Lak Shin Jeong, Andrea Cornia, Silvia Franchini, Silvia Madeddu, Annalisa Tait, Roberta Loddo, Sang Kook Lee, Giuseppina Sanna, Jayoung Song, Claudia Sorbi, Umberto Maria Battisti, Livio Brasili
Publikováno v:
Archives of Pharmacal Research. 40:537-549
Nucleoside analogues play an important role in antiviral, antibacterial and antineoplastic chemotherapy. Herein we report the synthesis, structural characterization and biological activity of some 4′-C -methyl- and -phenyl dioxolane-based nucleosid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff6ae36cb3846267acc001006e14ff3
https://doi.org/10.1007/s12272-016-0825-6
https://doi.org/10.1007/s12272-016-0825-6
Autor:
Paloma Tejera Nevado, Anabela Cordeiro-da-Silva, María Jesús Corral, Gesa Witt, Catarina Baptista, Rebecca C. Wade, G. Landi, José Mª Alunda, Juan J. Torrado, Bernhard Ellinger, Maria Kuzikov, Maria Paola Costi, Julia Eick, Stefano Mangani, Jeanette Reinshagen, Eugenia Bifeld, Nuno Santarém, Sheraz Gul, Manfred Kohler, Stefania Ferrari, Joachim Clos, María Dolores Jiménez-Antón, Lucia Dello Iacono, Birte Behrens, Philip Gribbon, Cecilia Pozzi, Oliver Keminer, Markus Wolf, Luca Costantino, Stefan Henrich, Matteo Trande, Rosaria Luciani, Ina Poehner, Flavio Di Pisa, Annalisa Tait, Federica Pellati, Chiara Borsari
Publikováno v:
'Journal of Medicinal Chemistry ', vol: 59, pages: 7598-7616 (2016)
Flavonoids represent a potential source of new antitrypanosomatidic leads. Starting from a library of natural products, we combined target-based screening on pteridine reductase 1 with phenotypic screening on Trypanosoma brucei for hit identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a889fd44ef2bdd1456774dc95d126ca2
https://doi.org/10.1021/acs.jmedchem.6b00698
https://doi.org/10.1021/acs.jmedchem.6b00698