Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Annalisa Maruca"'
Autor:
Gianmarco Gualtieri, Annalisa Maruca, Roberta Rocca, Fabrizio Carta, Emanuela Berrino, Alessandro Salatino, Carolina Brescia, Roberta Torcasio, Manuel Crispo, Francesco Trapasso, Stefano Alcaro, Claudiu T. Supuran, Giosuè Costa
Publikováno v:
Antioxidants, Vol 12, Iss 5, p 1115 (2023)
Hot pepper (Capsicum annuum) represents one of the most widespread functional foods of the Mediterranean diet, and is associated with a reduced risk of developing cardiovascular disease, cancer, and mental disorders. In particular, its bioactive spic
Externí odkaz:
https://doaj.org/article/96a9d964afc540caa14e3af4ce50f47b
Autor:
Roberta Rocca, Francesca Scionti, Matteo Nadai, Federica Moraca, Annalisa Maruca, Giosuè Costa, Raffaella Catalano, Giada Juli, Maria Teresa Di Martino, Francesco Ortuso, Stefano Alcaro, Pierosandro Tagliaferri, Pierfrancesco Tassone, Sara N. Richter, Anna Artese
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 548 (2022)
In mammalian cells, telomerase transcribes telomeres in large G-rich non-coding RNA, known as telomeric repeat-containing RNA (TERRA), which folds into noncanonical nucleic acid secondary structures called G-quadruplexes (G4s). Since TERRA G4 has bee
Externí odkaz:
https://doaj.org/article/e700cf89bb5342489b1987bc22c39c63
Autor:
Raffaella Catalano, Annalisa Maruca, Roberta Rocca, Pierfrancesco Tassone, Giulia Panzarella, Giosuè Costa, Francesco Ortuso, Stefano Alcaro
Publikováno v:
Future Medicinal Chemistry. 14:609-621
Background: The inhibition of PRC2, implicated in the pathogenesis of several tumors, can be a useful therapeutic strategy for cancer treatment. In the literature, two types of PRC2 modulators are reported: competitive inhibitors of S-adenosyl methio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c506e7155a7385d6960668fc63105ee9
https://doi.org/10.4155/fmc-2022-0010
https://doi.org/10.4155/fmc-2022-0010
Autor:
Annalisa Maruca, Roberta Rocca, Raffaella Catalano, Francesco Mesiti, Giosuè Costa, Delia Lanzillotta, Alessandro Salatino, Francesco Ortuso, Francesco Trapasso, Stefano Alcaro, Anna Artese
Publikováno v:
Molecules, Vol 25, Iss 23, p 5524 (2020)
Mushrooms can be considered a valuable source of natural bioactive compounds with potential polypharmacological effects due to their proven antimicrobial, antiviral, antitumor, and antioxidant activities. In order to identify new potential anticancer
Externí odkaz:
https://doaj.org/article/c91b1db4ebd74f20a1130b26646785ad
Autor:
Giosuè Costa, Annalisa Maruca, Roberta Rocca, Francesca Alessandra Ambrosio, Emanuela Berrino, Fabrizio Carta, Francesco Mesiti, Alessandro Salatino, Delia Lanzillotta, Francesco Trapasso, Anna Artese, Stefano Alcaro, Claudiu T. Supuran
Publikováno v:
Antioxidants, Vol 9, Iss 9, p 775 (2020)
The tumor-associated isoenzymes hCA IX and hCA XII catalyze the hydration of carbon dioxide to bicarbonate and protons. These isoforms are highly overexpressed in many types of cancer, where they contribute to the acidification of the tumor environme
Externí odkaz:
https://doaj.org/article/4f0ad47a4c4c4c11b575a0df48d24c62
Publikováno v:
Molecules, Vol 25, Iss 15, p 3321 (2020)
The mechanisms of inflammation and cancer are intertwined by complex networks of signaling pathways. Dysregulations in the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway underlie several pathogenic conditions related
Externí odkaz:
https://doaj.org/article/e10b579b80ca4dc4b4ee2070da84f480
Autor:
Annalisa Maruca, Delia Lanzillotta, Roberta Rocca, Antonio Lupia, Giosuè Costa, Raffaella Catalano, Federica Moraca, Eugenio Gaudio, Francesco Ortuso, Anna Artese, Francesco Trapasso, Stefano Alcaro
Publikováno v:
Molecules, Vol 25, Iss 9, p 2174 (2020)
Essential oils (EOs) are popular in aromatherapy, a branch of alternative medicine that claims their curative effects. Moreover, several studies reported EOs as potential anti-cancer agents by inducing apoptosis in different cancer cell models. In th
Externí odkaz:
https://doaj.org/article/b1805e789d6341aeb5043a4577967cd7
Autor:
Pierre Koch, Andreas Brunschweiger, Vigneshwaran Namasivayam, Stefan Ullrich, Annalisa Maruca, Beatrice Lazzaretto, Petra Küppers, Sonja Hinz, Jörg Hockemeyer, Michael Wiese, Jag Heer, Stefano Alcaro, Katarzyna Kiec-Kononowicz, Christa E. Müller
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Tetrahydropyrazino-annelated theophylline (1,3-dimethylxanthine) derivatives have previously been shown to display increased water-solubility as compared to the parent xanthines due to their basic character. In the present study, we modified this pro
Externí odkaz:
https://doaj.org/article/8ac885faa3b14e47a630ed6570da0d0f
Autor:
Francesco Ortuso, Donatella Bagetta, Annalisa Maruca, Carmine Talarico, Maria L. Bolognesi, Norbert Haider, Fernanda Borges, Sharon Bryant, Thierry Langer, Hanoch Senderowitz, Stefano Alcaro
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
For every lead compound developed in medicinal chemistry research, numerous other inactive or less active candidates are synthetized/isolated and tested. The majority of these compounds will not be selected for further development due to a sub-optima
Externí odkaz:
https://doaj.org/article/48ebb914cdde44b993c7c7060ad90c09
Autor:
Stefano Alcaro, Francesco Mesiti, Annalisa Maruca, Fernanda Borges, Alexandra Gaspar, Sheraz Gul, Oliver Keminer, Sandra Barreiro, Carlos M.C.G. Fernandes, Renata Silva, Roberta Rocca, Eva Gil Martins, Daniel Chavarria
Publikováno v:
Journal of Medicinal Chemistry. 64:11169-11182
Chromone-3-phenylcarboxamides (Crom-1 and Crom-2) were identified as potent, selective, and reversible inhibitors of human monoamine oxidase B (hMAO-B). Since they exhibit some absorption, distribution, metabolism, and excretion (ADME)-toxicity liabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdc6f4ff88e95004669abf049b9cc78
https://doi.org/10.1021/acs.jmedchem.1c00510
https://doi.org/10.1021/acs.jmedchem.1c00510