Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Annalisa Marsico"'
Autor:
Marc Horlacher, Nils Wagner, Lambert Moyon, Klara Kuret, Nicolas Goedert, Marco Salvatore, Jernej Ule, Julien Gagneur, Ole Winther, Annalisa Marsico
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-37 (2023)
Abstract We present RBPNet, a novel deep learning method, which predicts CLIP-seq crosslink count distribution from RNA sequence at single-nucleotide resolution. By training on up to a million regions, RBPNet achieves high generalization on eCLIP, iC
Externí odkaz:
https://doaj.org/article/445877a9fcac48ce99e6d0fd0251c840
Autor:
Stefanie M. Herbel, Lambert Moyon, Marvin Christ, Eslam M. Elsayed, Brian E. Caffrey, Silke Malmsheimer, Iwan Grin, Kerstin Hoffmann, Kristin Surmann, Sascha Blankenburg, Anna Lena Jung, Christina E. Herkt, Marco Borsò, Beyza Bozdag, Axel Imhof, Anke Becker, Samuel Wagner, Gert Bange, Uwe Völker, Wilhelm Bertrams, Annalisa Marsico, Bernd Schmeck
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 2042-2058 (2022)
Legionella pneumophila (L.p.) is a bacterial pathogen which is a common causative agent of pneumonia. In humans, it infects alveolar macrophages and transfers hundreds of virulence factors that interfere with cellular signalling pathways and the tran
Externí odkaz:
https://doaj.org/article/3cfbe5db3b0f4145a005db5fed54388b
Autor:
Michal Pardo, Svenja Offer, Elena Hartner, Sebastiano Di Bucchianico, Christoph Bisig, Stefanie Bauer, Jana Pantzke, Elias J. Zimmermann, Xin Cao, Stephanie Binder, Evelyn Kuhn, Anja Huber, Seongho Jeong, Uwe Käfer, Eric Schneider, Arunas Mesceriakovas, Jan Bendl, Ramona Brejcha, Angela Buchholz, Daniela Gat, Thorsten Hohaus, Narges Rastak, Erwin Karg, Gert Jakobi, Markus Kalberer, Tamara Kanashova, Yue Hu, Christoph Ogris, Annalisa Marsico, Fabian Theis, Tali Shalit, Thomas Gröger, Christopher P. Rüger, Sebastian Oeder, Jürgen Orasche, Andreas Paul, Till Ziehm, Zhi-Hui Zhang, Thomas Adam, Olli Sippula, Martin Sklorz, Jürgen Schnelle-Kreis, Hendryk Czech, Astrid Kiendler-Scharr, Ralf Zimmermann, Yinon Rudich
Publikováno v:
Environment International, Vol 166, Iss , Pp 107366- (2022)
The health effects of exposure to secondary organic aerosols (SOAs) are still limited. Here, we investigated and compared the toxicities of soot particles (SP) coated with β-pinene SOA (SOAβPin-SP) and SP coated with naphthalene SOA (SOANap-SP) in
Externí odkaz:
https://doaj.org/article/bd48c19d14b74b3a80d1bdf5c378cd84
Autor:
Guido Pacini, Ilona Dunkel, Norbert Mages, Verena Mutzel, Bernd Timmermann, Annalisa Marsico, Edda G. Schulz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
X-chromosome inactivation (XCI) ensures dosage compensation between the sexes. Here the authors perform allele-specific single-cell RNA sequencing in differentiating mouse embryonic stem cells to provide a detailed profile of the onset of XCI.
Externí odkaz:
https://doaj.org/article/fb6c9598aa694328ac2e4a2c1b16bd7b
Autor:
Yue Hu, Ghalia Rehawi, Lambert Moyon, Nathalie Gerstner, Christoph Ogris, Janine Knauer-Arloth, Florian Bittner, Annalisa Marsico, Nikola S. Mueller
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
COVID-19 is a heterogeneous disease caused by SARS-CoV-2. Aside from infections of the lungs, the disease can spread throughout the body and damage many other tissues, leading to multiorgan failure in severe cases. The highly variable symptom severit
Externí odkaz:
https://doaj.org/article/61cf86274b1a4c7a937948675af97a9b
Autor:
Luigina Micolucci, Giulia Matacchione, Maria Cristina Albertini, Massimo Marra, Deborah Ramini, Angelica Giuliani, Jacopo Sabbatinelli, Antonio Domenico Procopio, Fabiola Olivieri, Annalisa Marsico, Vladia Monsurrò
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5123 (2023)
The nuclear factor NF-kB is the master transcription factor in the inflammatory process by modulating the expression of pro-inflammatory genes. However, an additional level of complexity is the ability to promote the transcriptional activation of pos
Externí odkaz:
https://doaj.org/article/6b5d57bb7c7748b68ef47dab948510da
Autor:
Denise Thiel, Nataša Djurdjevac Conrad, Evgenia Ntini, Ria X. Peschutter, Heike Siebert, Annalisa Marsico
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-16 (2019)
Abstract Background Although several studies have provided insights into the role of long non-coding RNAs (lncRNAs), the majority of them have unknown function. Recent evidence has shown the importance of both lncRNAs and chromatin interactions in tr
Externí odkaz:
https://doaj.org/article/00f6521a06a64bf8ab4bacf3c1cbb07b
Autor:
Christina E. Herkt, Brian E. Caffrey, Kristin Surmann, Sascha Blankenburg, Manuela Gesell Salazar, Anna L. Jung, Stefanie M. Herbel, Kerstin Hoffmann, Leon N. Schulte, Wei Chen, Alexandra Sittka-Stark, Uwe Völker, Martin Vingron, Annalisa Marsico, Wilhelm Bertrams, Bernd Schmeck
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Legionella pneumophila is an important cause of pneumonia. It invades alveolar macrophages and manipulates the immune response by interfering with signaling pathways and gene transcription to support its own replication. MicroRNAs (miRNAs) a
Externí odkaz:
https://doaj.org/article/f562f453df8b4591a2a3cac252c1f3ca
Autor:
Evgenia Ntini, Annita Louloupi, Julia Liz, Jose M. Muino, Annalisa Marsico, Ulf Andersson Vang Ørom
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
The functional role of dissociation of long ncRNAs from chromatin is poorly understood. Here, the authors provide evidence that release of the long ncRNA AROD from chromatin enhances DKK1 transcription, and suggest that this regulatory mechanism of t
Externí odkaz:
https://doaj.org/article/577c083a37dd46d1bd8361053bbf1dba
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-17 (2017)
Abstract The iCLIP and eCLIP techniques facilitate the detection of protein–RNA interaction sites at high resolution, based on diagnostic events at crosslink sites. However, previous methods do not explicitly model the specifics of iCLIP and eCLIP
Externí odkaz:
https://doaj.org/article/06d1e13a469d442bbab128eded07c67e