Structural and functional diversity of native brain neuronal nicotinic receptors

Autor: Cecilia Gotti, Patrizia Pedrazzi, Irene Manfredi, Luca Pucci, Milena Moretti, Annalisa Gaimarri, Stefania Guiducci, Francesco Clementi, Michele Zoli, Alice Fornari

Publikováno v: Biochemical Pharmacology; Vol 78

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels present in the central and peripheral nervous systems, that are permeable to mono- and divalent cations. They share a common basic structure but their pharm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196d6b50a1268be28c5229849b2a6741

A comparative study of the effects of the intravenous self-administration or subcutaneous minipump infusion of nicotine on the expression of brain neuronal nicotinic receptor subtypes

Autor: Manolo Mugnaini, Cecilia Gotti, Francesco Clementi, Michele Zoli, Annalisa Gaimarri, Francesco Pistillo, Michela Tessari, Milena Moretti, Irene Manfredi

Publikováno v: Molecular pharmacology. 78(2)

Long-term nicotine exposure changes neuronal acetylcholine nicotinic receptor (nAChR) subtype expression in the brains of smokers and experimental animals. The aim of this study was to investigate nicotine-induced changes in nAChR expression in two m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899f4640de96bcc6ad6f03588c1e3384
https://pubmed.ncbi.nlm.nih.gov/20439469

Heterogeneity and complexity of native brain nicotinic receptors

Autor: Milena Moretti, Alessio Zanardi, Franceso Clementi, Michele Zoli, Annalisa Gaimarri, Cecilia Gotti

Publikováno v: Biochemical pharmacology. 74(8)

Neuronal cholinergic nicotinic receptors (nAChRs) are a heterogeneous class of cationic channels that are widely distributed in the nervous system that have specific functional and pharmacological properties. They consist of homologous subunits encod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7702d1fbdbba7c2b7ccb099235e320ff
https://pubmed.ncbi.nlm.nih.gov/17597586

Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation

Autor: Iwo Bohr, Cecilia Gotti, Silvia Vailati, Jan Petter Larsen, Ian G. McKeith, Jennifer A. Court, Dag Aarsland, Emanuele Sher, Iryna Ziabreva, Robert H. Perry, Renato Longhi, Milena Moretti, Francesco Clementi, Loredana Riganti, Ruth E. Beattie, Annalisa Gaimarri

Publikováno v: Neurobiology of disease 23 (2006): 481–489. doi:10.1016/j.nbd.2006.04.005
info:cnr-pdr/source/autori:Gotti C.(2); Moretti M.(2); Bohr I.(1); Ziabreva I.(1); Vailati S.(2); Longhi R.(2); Riganti L.(2); Gaimarri A.(2); McKeith I.G.(4); Perry R.H.(1); Aarsland D.; Larsen J.P.(4); Sher E.(5); Beattie R.(1); Clementi F.(2); Court J.A(1) ./titolo:Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation/doi:10.1016%2Fj.nbd.2006.04.005/rivista:Neurobiology of disease/anno:2006/pagina_da:481/pagina_a:489/intervallo_pagine:481–489/volume:23
Neurobiology of Disease, Vol 23, Iss 2, Pp 481-489 (2006)

Antibodies raised against human alpha 2-6 and beta 2-4 nicotinic receptor subunits were utilized to fractionate H-3-epibatidine binding in human temporal cortex and striatum. The predominant receptor subtypes in both regions contained alpha 4 and bet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fad39b1d98f8fd45b94ab118c546bc9
https://pubmed.ncbi.nlm.nih.gov/16759874