Abstract 4007: Efficacy of vepafestinib in preclinical models of RET fusion-driven sarcoma models

Autor: Igor Odintsov, Ryan C. Cheng, Allan J. Lui, Tom Zhang, Yue C. Lu, Renate I. Kurth, Morana Vojnic, Inna Khodos, Qing Chang, Kevin Chen, Claudio Giuliano, Annalisa Bonifacio, Isao Miyazaki, Elisa de Stanchina, Emanuela Lovati, Marc Ladanyi, Romel Somwar

Publikováno v: Cancer Research. 83:4007-4007

Background: Vepafestinib (TAS0953/HM06, Vepa) is a 2nd generation RET-selective inhibitor that effectively penetrates the brain, and inhibits the wildtype RET kinase domain (KD) and RET KD mutants (G810, V804, Y806, L730) (presented at AACR-NCI-EROTC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a8ee760a9e43cc5a90e09677ce89e0a
https://doi.org/10.1158/1538-7445.am2023-4007

Abstract P233: TAS0953/HM06 is effective in preclinical models of diverse tumor types driven by RET alterations

Autor: Igor Odintsov, Renate I. Kurth, Kota Ishizawa, Lukas Delasos, Allan J.W. Lui, Inna Khodos, Connor J. Hagen, Qing Chang, Marissa S. Mattar, Morana Vojnic, Siddharth Kunte, Annalisa Bonifacio, Claudio Giuliano, Elisa De Stanchina, Emily Cheng, Emanuela Lovati, Marc Ladanyi, Romel Somwar

Publikováno v: Molecular Cancer Therapeutics. 20:P233-P233

Fusions involving RET receptor tyrosine kinase are a common driver of tumors across different tissue types, such as lung, thyroid, colorectal, soft tissue and others. TAS0953/HM06 (hereby referred to as HM06) is a novel 2ndgeneration RET-specific inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d2719c6572dbc5c35c376f1f9530a3b
https://doi.org/10.1158/1535-7163.targ-21-p233

Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle

Autor: Bernard Geny, Joffrey Zoll, Stephan Krähenbühl, Anna-Isabel Schlagowski, François Singh, Jamal Bouitbir, Anne-Laure Charles, Annalisa Bonifacio, Andoni Echaniz-Laguna

Publikováno v: Antioxidants & Redox Signaling. 24:84-98

Although statins are the most widely used cholesterol-lowering agents, they are associated with a variety of muscle complaints. The goal of this study was to characterize the effects of statins on the mitochondrial apoptosis pathway induced by mitoch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d343826e3e576aedf064bb476de71faf
https://doi.org/10.1089/ars.2014.6190

Contractile function and energy metabolism of skeletal muscle in rats with secondary carnitine deficiency

Autor: Annalisa Bonifacio, Priska Kaufmann, Albert Urwyler, Stephan Krähenbühl, Jamal Bouitbir, François Singh, Paul A. Roberts

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 309:E265-E274

The consequences of carnitine depletion upon metabolic and contractile characteristics of skeletal muscle remain largely unexplored. Therefore, we investigated the effect of N-trimethyl-hydrazine-3-propionate (THP) administration, a carnitine analog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe49e27c874b34de0c442d2cf57ed6dd
https://doi.org/10.1152/ajpendo.00001.2015

Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo

Autor: Peter J. Mullen, Stephan Krähenbühl, Luiz Carlos Carvalho Navegantes, Ileana Scurtu Mityko, Jamal Bouitbir, Annalisa Bonifacio

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Simvastatin is effective and well tolerated, with adverse reactions mainly affecting skeletal muscle. Important mechanisms for skeletal muscle toxicity include mitochondrial impairment and increased expression of atrogin-1. The aim was to study the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3154f2a622ef7fdfea2810a04d9f3349
https://pubmed.ncbi.nlm.nih.gov/25300705