Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Annalaura Brai"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7588 (2024)
Globalization and climate change are both contributing to an increase in the number of potentially invasive algae in coastal areas. In terms of biodiversity and financial losses, the invasiveness of algae has become a significant issue in Orbetello L
Externí odkaz:
https://doaj.org/article/1280146da9424cde821d3a1fe1262157
Identification of Novel Non-Nucleoside Inhibitors of Zika Virus NS5 Protein Targeting MTase Activity
Autor:
Diego Fiorucci, Micaela Meaccini, Giulio Poli, Maria Alfreda Stincarelli, Chiara Vagaggini, Simone Giannecchini, Priscila Sutto-Ortiz, Bruno Canard, Etienne Decroly, Elena Dreassi, Annalaura Brai, Maurizio Botta
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2437 (2024)
Zika virus (ZIKV) is a positive-sense single-stranded virus member of the Flaviviridae family. Among other arboviruses, ZIKV can cause neurological disorders such as Guillain Barré syndrome, and it can have congenital neurological manifestations and
Externí odkaz:
https://doaj.org/article/0afb7cf099f34ac8aef2b89648debb2a
Publikováno v:
Chemistry, Vol 4, Iss 4, Pp 1714-1722 (2022)
A single clean, good-yielding, environment-friendly microwave-assisted procedure for O-silylation of uridine with tert-butyldimethylsilyl chloride (TBDMSCl), 1,8-Diazabicyclo(5.4.0)undec-7-ene (DBU) and potassium nitrate as catalyst under solvent-fre
Externí odkaz:
https://doaj.org/article/d40d8606b78c4392ae37610bfd191298
Autor:
Federica Poggialini, Chiara Vagaggini, Annalaura Brai, Claudia Pasqualini, Anna Carbone, Francesca Musumeci, Silvia Schenone, Elena Dreassi
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1527 (2023)
Although patients would rather oral therapies to injections, the gastrointestinal tract’s low permeability makes this method limiting for most compounds, including anticancer drugs. Due to their low bioavailability, oral antitumor therapies suffer
Externí odkaz:
https://doaj.org/article/0c24052588a24c2d985bde16104856df
Autor:
Annalaura Brai, Federica Poggialini, Claudia Pasqualini, Claudia Immacolata Trivisani, Chiara Vagaggini, Elena Dreassi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9225 (2023)
In recent decades, vaccines have been extraordinary resources to prevent pathogen diffusion and cancer. Even if they can be formed by a single antigen, the addition of one or more adjuvants represents the key to enhance the response of the immune sig
Externí odkaz:
https://doaj.org/article/e8ed2cb130f6409a99722f7a46ee8552
Autor:
Federica Poggialini, Chiara Vagaggini, Annalaura Brai, Claudia Pasqualini, Emmanuele Crespan, Giovanni Maga, Cecilia Perini, Noemi Cabella, Lorenzo Botta, Francesca Musumeci, Maria Frosini, Silvia Schenone, Elena Dreassi
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 453 (2023)
The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies for the treatment of glioblastoma (GBM). Pyrazolo[3,4-d]pyrimidines have already been reported as promising small molecules active as c-Src/Abl dual
Externí odkaz:
https://doaj.org/article/ccd671932b5b41839203be632d83a138
Autor:
Annalaura Brai, Federica Poggialini, Chiara Vagaggini, Claudia Pasqualini, Sauro Simoni, Valeria Francardi, Elena Dreassi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2296 (2023)
The progression of drugs into clinical phases requires proper toxicity assessment in animals and the correct identification of possible metabolites. Accordingly, different animal models are used to preliminarily evaluate toxicity and biotransformatio
Externí odkaz:
https://doaj.org/article/621fe1bc881a433e8b3ca76658eb7247
Autor:
Annalaura Brai, Valentina Riva, Letizia Clementi, Lucia Falsitta, Claudio Zamperini, Virginia Sinigiani, Claudio Festuccia, Samantha Sabetta, Davide Aiello, Camilla Roselli, Anna Garbelli, Claudia Immacolata Trivisani, Laura Maccari, Francesca Bugli, Maurizio Sanguinetti, Pierpaolo Calandro, Mario Chiariello, Paola Quaranta, Lorenzo Botta, Adriano Angelucci, Giovanni Maga, Maurizio Botta
Publikováno v:
Cancers, Vol 13, Iss 21, p 5569 (2021)
DDX3X is an ATP-dependent RNA helicase that has recently attracted interest for its involvement in viral replication and oncogenic progression. Starting from hit compounds previously identified by our group, we have designed and synthesized a new ser
Externí odkaz:
https://doaj.org/article/bfbd4134848143b985f3e9e04faac2e5
Autor:
Annalaura Brai, Stefania Ronzini, Valentina Riva, Lorenzo Botta, Claudio Zamperini, Matteo Borgini, Claudia Immacolata Trivisani, Anna Garbelli, Carla Pennisi, Adele Boccuto, Francesco Saladini, Maurizio Zazzi, Giovanni Maga, Maurizio Botta
Publikováno v:
Molecules, Vol 24, Iss 21, p 3988 (2019)
The human ATPase/RNA helicase X-linked DEAD-box polypeptide 3 (DDX3X) emerged as a novel therapeutic target in the fight against both infectious diseases and cancer. Herein, a new family of DDX3X inhibitors was designed, synthesized, and tested for i
Externí odkaz:
https://doaj.org/article/9403db9a6536463ab27126f849bbc5c4
Autor:
Valeria Cagno, Cristina Tintori, Andrea Civra, Roberta Cavalli, Marika Tiberi, Lorenzo Botta, Annalaura Brai, Giulio Poli, Caroline Tapparel, David Lembo, Maurizio Botta
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208333 (2018)
Viral infections are an important cause of death worldwide. Unfortunately, there is still a lack of antiviral drugs or vaccines for a large number of viruses, and this represents a remarkable challenge particularly for emerging and re-emerging viruse
Externí odkaz:
https://doaj.org/article/e8c633debfbb41c39410c7b18449093c