Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Annahita Sallmyr"'
Autor:
Seema Khattri Bhandari, Nathaniel Wiest, Annahita Sallmyr, Ruofei Du, Laure Ferry, Pierre-Antoine Defossez, Alan E. Tomkinson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract DNA ligase I (LigI), the predominant enzyme that joins Okazaki fragments, interacts with PCNA and Pol δ. LigI also interacts with UHRF1, linking Okazaki fragment joining with DNA maintenance methylation. Okazaki fragments can also be joined
Externí odkaz:
https://doaj.org/article/3144e10f780c4a7b930dcc25e9019c23
Autor:
Alan E. Tomkinson, Bennett Van Houten, Vera Roginskaya, Yoshihiro Matsumoto, Annahita Sallmyr
Suppl. Table 1: IC50 values for the DNA Ligase inhibitor L67 for three cancer cells lines, a telomerase-immortalized fibroblast and the Rho minus derivatives of each of the cell lines; Suppl. Table 2: DNA sequences of primers used for amplification o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fe2b33ba51181bcda1b44240e6a897
https://doi.org/10.1158/0008-5472.22412627.v1
https://doi.org/10.1158/0008-5472.22412627.v1
Autor:
Alan E. Tomkinson, Bennett Van Houten, Vera Roginskaya, Yoshihiro Matsumoto, Annahita Sallmyr
Panel A. Effect of L67 on the cell cycle distribution of synchronized HCA-Ltrt cells. Panel B. Effect of L67 on mitochondrial superoxide level in HCA-Ltrt cells and HCA-Ltrt Rho minus cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3581fe508af73c5a8f2c916c554d116
https://doi.org/10.1158/0008-5472.22412636.v1
https://doi.org/10.1158/0008-5472.22412636.v1
Autor:
Alan E. Tomkinson, Bennett Van Houten, Vera Roginskaya, Yoshihiro Matsumoto, Annahita Sallmyr
Panel A. Induction of gammaH2AX foci in HeLa cells, HeLa Rho minus cells and HeLa cells expressing mitochondrially targeted E. coli DNA ligase by L67. Panel B. N-acetyl cysteine inhibits L67-induced autophosphorylation of ATM in HeLa cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39918fd872f0fbbbb145a3742fe66984
https://doi.org/10.1158/0008-5472.22412642.v1
https://doi.org/10.1158/0008-5472.22412642.v1
Autor:
Alan E. Tomkinson, Bennett Van Houten, Vera Roginskaya, Yoshihiro Matsumoto, Annahita Sallmyr
Supplementary Materials and methods plus legends for six supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd3f40f9e9c9db55cfc5c47d0942df2
https://doi.org/10.1158/0008-5472.22412630.v1
https://doi.org/10.1158/0008-5472.22412630.v1
Autor:
Alan E. Tomkinson, Bennett Van Houten, Vera Roginskaya, Yoshihiro Matsumoto, Annahita Sallmyr
Panel A. Characterization of HeLA cells expressing mitochondrially-targeted E. coli DNA ligase. DNA encoding the E. coli DNA detected by PCR and expression of GFP-tagged E. coli DNA ligase detected by immunoblotting. Panel B. Effect of L67 on DNA lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c6f8254fe81586581d6123cb1df7cf
https://doi.org/10.1158/0008-5472.22412648.v1
https://doi.org/10.1158/0008-5472.22412648.v1
Autor:
Alan E. Tomkinson, Bennett Van Houten, Vera Roginskaya, Yoshihiro Matsumoto, Annahita Sallmyr
L67 does not induce cleavage of caspases 7 or 9 in HeLa cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ac794028a874b7da0eb43d113fd7c4
https://doi.org/10.1158/0008-5472.22412633.v1
https://doi.org/10.1158/0008-5472.22412633.v1
Autor:
Alan E. Tomkinson, Bennett Van Houten, Vera Roginskaya, Yoshihiro Matsumoto, Annahita Sallmyr
Elevated levels of DNA ligase IIIα (LigIIIα) have been identified as a biomarker of an alteration in DNA repair in cancer cells that confers hypersensitivity to a LigIIIα inhibitor, L67, in combination with a poly (ADP-ribose) polymerase inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96e35d0841b55e9d08b9290671cfc00c
https://doi.org/10.1158/0008-5472.c.6508481.v1
https://doi.org/10.1158/0008-5472.c.6508481.v1
Publikováno v:
DNA Repair (Amst)
To ensure genome integrity, the joining of breaks in the phosphodiester backbone of duplex DNA is required during DNA replication and to complete the repair of almost all types of DNA damage. In human cells, this task is accomplished by DNA ligases e
Autor:
Annahita Sallmyr, Alan E. Tomkinson
Publikováno v:
Journal of Biological Chemistry. 293:10536-10546
Alternative end-joining (a-EJ) pathways, which repair DNA double-strand breaks (DSBs), are initiated by end resection that generates 3' single strands. This reaction is shared, at least in part, with homologous recombination but distinguishes a-EJ fr