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Diclofenac and Its Derivatives As Tools for Studying Human Cytochromes P450 Active Sites: Particular Efficiency and Regioselectivity of P450 2Cs

Autor: Annah Mancy, Marie Antignac, Virginie Mouries, Patrick M. Dansette, Daniel Mansuy, Sylvie Dijols, Nguyet-Thanh Ha Duong, Claire Minoletti, Pierrette Battioni

Publikováno v: Biochemistry. 38:14264-14270

A comparison of the oxidations of diclofenac with microsomes of yeasts expressing various human liver cytochromes P450 showed that P450 2C9 regioselectively led to 4'-hydroxy diclofenac (4'-OHD) whereas P450 3A4 only led to 5-hydroxy diclofenac (5-OH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de86ee2b24db788473506991e9bc7d04
https://doi.org/10.1021/bi991195u

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The substrate binding site of human liver cytochrome P450 2C9: an approach using designed tienilic acid derivatives and molecular modeling

Autor: Patrick M. Dansette, Sylvie Dijols, Pierre Broto, Annah Mancy, Daniel Mansuy

Publikováno v: Biochemistry. 34(33)

Biochemical experiments, using the well-defined human liver CYP2C9 expressed in yeast, and molecular modeling techniques were used to derive a predictive model for substrates of CYP2C9. The ability of 10 2-aroylthiophenes related to tienilic acid to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c6b693a4f7109333ee18bda17c8e50
https://pubmed.ncbi.nlm.nih.gov/7654690

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