Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation

Autor: Virginia S. Lioy, Jean-Noël Lorenzi, Soumaya Najah, Thibault Poinsignon, Hervé Leh, Corinne Saulnier, Bertrand Aigle, Sylvie Lautru, Annabelle Thibessard, Olivier Lespinet, Pierre Leblond, Yan Jaszczyszyn, Kevin Gorrichon, Nelle Varoquaux, Ivan Junier, Frédéric Boccard, Jean-Luc Pernodet, Stéphanie Bury-Moné

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Streptomyces bacteria have a linear chromosome, with core genes located in the central region and gene clusters for specialized metabolite biosynthesis found in the ‘arms’. Here, Lioy et al. show that such chromosome structure correlates with gen

Externí odkaz: https://doaj.org/article/69ebdcca68044d26ae4c0c82ce1b8f3e

Negative Correlation between Lipid Content and Antibiotic Activity in Streptomyces: General Rule and Exceptions

Autor: Michelle David, Clara Lejeune, Sonia Abreu, Annabelle Thibessard, Pierre Leblond, Pierre Chaminade, Marie-Joelle Virolle

Publikováno v: Antibiotics, Vol 9, Iss 6, p 280 (2020)

Streptomycetes are well known antibiotic producers and are among the rare prokaryotes able to store carbon as lipids. Previous comparative studies of the weak antibiotic producer Streptomyces lividans with its ppk mutant and with Streptomyces coelico

Externí odkaz: https://doaj.org/article/fcefc982a1cf4f9196c52d2f72687535

Comparative Genomics among Closely Related Streptomyces Strains Revealed Specialized Metabolite Biosynthetic Gene Cluster Diversity

Autor: Cláudia M. Vicente, Annabelle Thibessard, Jean-Noël Lorenzi, Mabrouka Benhadj, Laurence Hôtel, Djamila Gacemi-Kirane, Olivier Lespinet, Pierre Leblond, Bertrand Aigle

Publikováno v: Antibiotics, Vol 7, Iss 4, p 86 (2018)

Specialized metabolites are of great interest due to their possible industrial and clinical applications. The increasing number of antimicrobial resistant infectious agents is a major health threat and therefore, the discovery of chemical diversity a

Externí odkaz: https://doaj.org/article/1f1fd61d91264e428d9b63891fe5224f

Ribosomal RNA operons define a central functional compartment in the Streptomyces chromosome

Autor: Jean-Noël Lorenzi, Annabelle Thibessard, Virginia S. Lioy, Frédéric Boccard, Pierre Leblond, Jean-Luc Pernodet, Stéphanie Bury-Moné

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2022, 50 (20), pp.11654-11669. ⟨10.1093/nar/gkac1076⟩

Streptomyces are prolific producers of specialized metabolites with applications in medicine and agriculture. These bacteria possess a large linear chromosome genetically compartmentalized: core genes are grouped in the central part, while terminal r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbd5993685c68686414830f3ac5386b
https://pubmed.ncbi.nlm.nih.gov/36408918

Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation

Autor: Nelle Varoquaux, Bertrand Aigle, Sylvie Lautru, Jean-Noël Lorenzi, Corinne Saulnier, Jean-Luc Pernodet, Ivan Junier, Virginia S. Lioy, Yan Jaszczyszyn, Kevin Gorrichon, Hervé Leh, Frédéric Boccard, Thibault Poinsignon, Soumaya Najah, Pierre Leblond, Stéphanie Bury-Moné, Annabelle Thibessard, Olivier Lespinet

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12, pp.5221. ⟨10.1038/s41467-021-25462-1⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-25462-1⟩
BioRxiv
Nature Communications, 2021, 12, pp.5221. ⟨10.1038/s41467-021-25462-1⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Bacteria of the genus Streptomyces are prolific producers of specialized metabolites, including antibiotics. The linear chromosome includes a central region harboring core genes, as well as extremities enriched in specialized metabolite biosynthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277c6baa0aecb3b4d45b4196a94f7624
https://doi.org/10.21203/rs.3.rs-145840/v1