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Publikováno v:
Best Practice & Research Clinical Haematology. 36:101448
Autor:
Annabelle Tann, Tina Seitz, Mladen V. Tzvetkov, Jürgen Brockmöller, Thomas Prukop, Ole Jensen, Johannes Matthaei, Sina Tadjerpisheh
Publikováno v:
Clinical pharmacology and therapeutics. 105(1)
Cycloguanil, the active metabolite of proguanil, acts on malaria schizonts in erythrocytes and hepatocytes. We analyzed the impact of the organic cation transporter OCT1 on hepatocellular uptake and pharmacokinetics of proguanil and cycloguanil. OCT1