Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Annabelle Lewis"'
Autor:
Matthew Brown, Alicia Leon, Katarzyna Kedzierska, Charlotte Moore, Hayley L Belnoue‐Davis, Susanne Flach, John P Lydon, Francesco J DeMayo, Annabelle Lewis, Tjalling Bosse, Ian Tomlinson, David N Church
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 10, Pp n/a-n/a (2023)
Abstract High‐risk endometrial cancer has poor prognosis and is increasing in incidence. However, understanding of the molecular mechanisms which drive this disease is limited. We used genetically engineered mouse models (GEMM) to determine the fun
Externí odkaz:
https://doaj.org/article/5c8f6de2c4ae45eeb10187d03d135ae1
Autor:
Ann-Marie Baker, Weini Huang, Xiao-Ming Mindy Wang, Marnix Jansen, Xiao-Jun Ma, Jeffrey Kim, Courtney M. Anderson, Xingyong Wu, Liuliu Pan, Nan Su, Yuling Luo, Enric Domingo, Timon Heide, Andrea Sottoriva, Annabelle Lewis, Andrew D. Beggs, Nicholas A. Wright, Manuel Rodriguez-Justo, Emily Park, Ian Tomlinson, Trevor A. Graham
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Methods that analyze intra-tumor genetic heterogeneity often do not preserve the spatial context of tumor subclones. Here, the authors present BaseScope, a mutation-specific RNA in situ hybridization assay and spatially map colorectal cancer and aden
Externí odkaz:
https://doaj.org/article/04a8b784261d4d7da0ef04bead32687f
Autor:
Séan M. O’Cathail, Chieh-Hsi Wu, Rachael Thomas, Maria A. Hawkins, Tim S. Maughan, Annabelle Lewis
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1380 (2021)
Radiation resistance is a significant clinical problem in rectal cancer treatment, the mechanisms of which are poorly understood. NRF2 signalling is known to contribute to chemo/radioresistance in some cancers, but its role in therapeutic resistance
Externí odkaz:
https://doaj.org/article/43ca33c3e18d46bfa7617023c1a6cccd
Autor:
Annabelle Lewis, Luke Freeman-Mills, Elisa de la Calle-Mustienes, Rosa María Giráldez-Pérez, Hayley Davis, Emma Jaeger, Martin Becker, Nina C. Hubner, Luan N. Nguyen, Jorge Zeron-Medina, Gareth Bond, Hendrik G. Stunnenberg, Jaime J. Carvajal, Jose Luis Gomez-Skarmeta, Simon Leedham, Ian Tomlinson
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 983-990 (2014)
A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal
Externí odkaz:
https://doaj.org/article/2b9331b1c6724e84b883554db9034ce7
Autor:
Ian P M Tomlinson, Luis G Carvajal-Carmona, Sara E Dobbins, Albert Tenesa, Angela M Jones, Kimberley Howarth, Claire Palles, Peter Broderick, Emma E M Jaeger, Susan Farrington, Annabelle Lewis, James G D Prendergast, Alan M Pittman, Evropi Theodoratou, Bianca Olver, Marion Walker, Steven Penegar, Ella Barclay, Nicola Whiffin, Lynn Martin, Stephane Ballereau, Amy Lloyd, Maggie Gorman, Steven Lubbe, COGENT Consortium, CORGI Collaborators, EPICOLON Consortium, Bryan Howie, Jonathan Marchini, Clara Ruiz-Ponte, Ceres Fernandez-Rozadilla, Antoni Castells, Angel Carracedo, Sergi Castellvi-Bel, David Duggan, David Conti, Jean-Baptiste Cazier, Harry Campbell, Oliver Sieber, Lara Lipton, Peter Gibbs, Nicholas G Martin, Grant W Montgomery, Joanne Young, Paul N Baird, Steven Gallinger, Polly Newcomb, John Hopper, Mark A Jenkins, Lauri A Aaltonen, David J Kerr, Jeremy Cheadle, Paul Pharoah, Graham Casey, Richard S Houlston, Malcolm G Dunlop
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002105 (2011)
Genome-wide association studies (GWAS) have identified 14 tagging single nucleotide polymorphisms (tagSNPs) that are associated with the risk of colorectal cancer (CRC), and several of these tagSNPs are near bone morphogenetic protein (BMP) pathway l
Externí odkaz:
https://doaj.org/article/c10c8a90b2ce4383b4aa02c682b34728
Autor:
Annabelle Lewis
All students expect to have equal access to a good education but this is not always the case. Research has shown that students who experience discipline that removes them from the classroom are more likely to repeat a grade, drop out of school, and b
PTK6, a Non-Receptor–Tyrosine-Kinase, modulates the pathogenesis of breast and prostate cancers, and is recognized as a biomarker of breast cancer prognosis. There are over 30 known substrates of PTK6, including signal transducers, transcription fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2707df8b49c684b444983bb7bd3dc9f6
https://doi.org/10.20944/preprints202305.1789.v1
https://doi.org/10.20944/preprints202305.1789.v1
Publikováno v:
Results and problems in cell differentiation. 70
The organisation of the genome in its home, the cell nucleus, is reliant on a number of different aspects to establish, maintain and alter its functional non-random positioning. The genome is dispersed throughout a cell nucleus in specific chromosome
Autor:
Rachael Thomas, Tim Maughan, Maria A. Hawkins, Chieh-Hsi Wu, Annabelle Lewis, Sean M. O'Cathail
Publikováno v:
Antioxidants, Vol 10, Iss 1380, p 1380 (2021)
Antioxidants
Volume 10
Issue 9
Antioxidants
Volume 10
Issue 9
Radiation resistance is a significant clinical problem in rectal cancer treatment, the mechanisms of which are poorly understood. NRF2 signalling is known to contribute to chemo/radioresistance in some cancers, but its role in therapeutic resistance
Autor:
Daniel D. Buchanan, Holly Russell, Graham G. Giles, Roger L. Milne, Tracy A. O'Mara, Miriam Mints, Anne Keränen, Annabelle Lewis, Katarzyna Kedzierska, Melissa C. Southey, Ian Tomlinson, Emma Tham, Amanda B. Spurdle, Rachael Thomas, David N. Church
Publikováno v:
Clinical Epigenetics. 13
An amendment to this paper has been published and can be accessed via the original article.