Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Annabel Torres"'
Autor:
Chun Su, Matthew E. Johnson, Annabel Torres, Rajan M. Thomas, Elisabetta Manduchi, Prabhat Sharma, Parul Mehra, Carole Le Coz, Michelle E. Leonard, Sumei Lu, Kenyaita M. Hodge, Alessandra Chesi, James Pippin, Neil Romberg, Struan F. A. Grant, Andrew D. Wells
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
T cells are a major cell type involved in systemic lupus erythematosus (SLE). Here, the authors use promoter capture-C and ATAC-seq in human follicular T helper cells to identify SLE genes distant from GWAS loci (via 3D interaction) and validate the
Externí odkaz:
https://doaj.org/article/e8bc69a5fa22479099c81e256d349a2f
Autor:
Li Song, Ying Dou, Struan F.A. Grant, Vishesh R Patel, Chun Su, Zhe Zhang, Annabel Torres, Michelle Petri, Michelle E. Leonard, Sumei Lu, Kenyaita M. Hodge, Alessandra Chesi, Kelly Maurer, Andrew D. Wells, Lihua Shi, Kathleen E. Sullivan
Publikováno v:
J Immunol
The IL1A and IL1B genes lie in close proximity on chromosome 2 near the gene for their natural inhibitor, IL1RN. Despite diverse functions, they are all three inducible through TLR4 signaling but with distinct kinetics. This study analyzed transcript
Autor:
Michelle E. Leonard, Carole Le Coz, Annabel Torres, Struan F.A. Grant, Rajan M. Thomas, Chun Su, Kenyaita M. Hodge, Elisabetta Manduchi, Neil Romberg, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Sumei Lu, Parul Mehra, Prabhat K. Sharma, James A. Pippin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Systemic lupus erythematosus (SLE) is mediated by autoreactive antibodies that damage multiple tissues. Genome-wide association studies (GWAS) link >60 loci with SLE risk, but the causal variants and effector genes are largely unknown. We generated h
Autor:
Annabel Torres, Rajan M. Thomas, Matthew E. Johnson, Neil Romberg, Kenyaita M. Hodge, Michelle E. Leonard, Carole Le Coz, Struan F.A. Grant, Andrew D. Wells, Alessandra Chesi, James A. Pippin, Prabhat K. Sharma, Chun Su, Elisabetta Manduchi, Sumei Lu
Systemic lupus erythematosus (SLE) is a complex inflammatory disease mediated by autoreactive antibodies that damages multiple tissues in children and adults. Genome-wide association studies (GWAS) have statistically implicated hundreds of loci in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628e5305a6da9ee349a95198409f3f53
https://doi.org/10.1101/2019.12.20.885426
https://doi.org/10.1101/2019.12.20.885426
Publikováno v:
The Journal of Biological Chemistry
We previously discovered that systemic delivery of decorin for treatment of breast carcinoma xenografts induces paternally expressed gene 3 (Peg3), an imprinted gene encoding a zinc finger transcription factor postulated to function as a tumor suppre
Publikováno v:
The Journal of Immunology. 200:112.10-112.10
Costimulation through the TCR and CD28 drives T cell activation and differentiation. TCR engagement without CD28 results in anergy, a dominant state refractory to further stimulation. To understand how signals from CD28 and/or TCR imprint anergic and
Autor:
Jan B. Hoek, Thomas Neill, Annabel Torres, Raffaele Baffa, Renato V. Iozzo, Simone Buraschi, Rick T. Owens
Publikováno v:
The Journal of biological chemistry. 289(8)
Tumor cell mitochondria are key biosynthetic hubs that provide macromolecules for cancer progression and angiogenesis. Soluble decorin protein core, hereafter referred to as decorin, potently attenuated mitochondrial respiratory complexes and mitocho
Publikováno v:
Autophagy. 9(10)
DCN (decorin), an extracellular matrix constituent and archetypical small leucine-rich proteoglycan (SLRP), acts as a soluble tumor repressor. DCN exerts high-affinity binding interactions with receptor tyrosine kinases and evokes receptor internaliz
Autor:
Renato V. Iozzo, Atul Goyal, Chiara Poluzzi, James Smythies, Thomas Neill, Simone Buraschi, Rick T. Owens, Liliana Schaefer, Annabel Torres
Publikováno v:
Proceedings of the National Academy of Sciences. 110
Soluble decorin affects the biology of several receptor tyrosine kinases by triggering receptor internalization and degradation. We found that decorin induced paternally expressed gene 3 (Peg3), an imprinted tumor suppressor gene, and that Peg3 reloc