Výsledky vyhledávání - "Annabel S. Chyung"

Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss

Autor: A. Harrison Brody, Suho Lee, Annabel S. Chyung, Santiago V. Salazar, Timothy O. Cox, Laura T. Haas, Stephen M. Strittmatter

Publikováno v: The Journal of Neuroscience. 39:758-772

Dozens of genes have been implicated in late onset Alzheimer's disease (AD) risk, but none has a defined mechanism of action in neurons. Here, we show that the risk factor Pyk2 (PTK2B) localizes specifically to neurons in adult brain. Absence of Pyk2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81909e93e1c817c8e63a4dea3c51b89
https://doi.org/10.1523/jneurosci.1873-18.2018

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Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy

Autor: Arman Fesharaki-Zadeh, Stephen M. Strittmatter, Si Jie Tang, Levi M. Smith, Hideyuki Takahashi, Sarah Helena Nies, Anin Luo, Marius Chiasseu, Annabel S. Chyung

Publikováno v: Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-21 (2020)

Accumulation of misfolded phosphorylated Tau (Tauopathy) can be triggered by mutations or by trauma, and is associated with synapse loss, gliosis, neurodegeneration and memory deficits. Fyn kinase physically associates with Tau and regulates subcellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de850b967c4ae2bd9865fdc6dbed56f
http://europepmc.org/articles/PMC7329553

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