Platelets favor the outgrowth of established metastases

Autor: Maria J. Garcia-Leon, Cristina Liboni, Vincent Mittelheisser, Louis Bochler, Gautier Follain, Clarisse Mouriaux, Ignacio Busnelli, Annabel Larnicol, Florent Colin, Marina Peralta, Naël Osmani, Valentin Gensbittel, Catherine Bourdon, Rafael Samaniego, Angélique Pichot, Nicodème Paul, Anne Molitor, Raphaël Carapito, Martine Jandrot-Perrus, Olivier Lefebvre, Pierre H. Mangin, Jacky G. Goetz

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Despite abundant evidence demonstrating that platelets foster metastasis, anti-platelet agents have low therapeutic potential due to the risk of hemorrhages. In addition, whether platelets can regulate metastasis at the late stages of the di

Externí odkaz: https://doaj.org/article/2da522b6db60448cb066c2604318bcd1

Author Correction: Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells

Autor: Gautier Follain, Naël Osmani, Valentin Gensbittel, Nandini Asokan, Annabel Larnicol, Luc Mercier, Maria Jesus Garcia‑Leon, Ignacio Busnelli, Angelique Pichot, Nicodème Paul, Raphaël Carapito, Seiamak Bahram, Olivier Lefebvre, Jacky G. Goetz

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)

Externí odkaz: https://doaj.org/article/45888bde363441b999315d85c5cf9431

Metastatic Tumor Cells Exploit Their Adhesion Repertoire to Counteract Shear Forces during Intravascular Arrest

Autor: Naël Osmani, Gautier Follain, María J. García León, Olivier Lefebvre, Ignacio Busnelli, Annabel Larnicol, Sébastien Harlepp, Jacky G. Goetz

Publikováno v: Cell Reports, Vol 28, Iss 10, Pp 2491-2500.e5 (2019)

Summary: Cancer metastasis is a process whereby a primary tumor spreads to distant organs. We have demonstrated previously that blood flow controls the intravascular arrest of circulating tumor cells (CTCs) through stable adhesion to endothelial cell

Externí odkaz: https://doaj.org/article/340a71834c46465e9db97558ed0dc9be

Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort

Autor: Qian Zhang, Paul Bastard, Haiguo Wu, Adrian Gervais, Seiamak Bahram, Sylvain Mayeur, Sharvari Gujja, Anne Thomas, Alexandre Lederle, Julie Helms, Christiane Moog, Xavier Mariette, Alain Viari, Tristan Stemmelen, Christine Carapito, Olivier Hermine, Richard Li, Daniel A. Lidar, Cécile Macquin, Jean Sibilia, Géraldine Laumond, Shweta Kailasan, Leslie Muller, Sabrina Bibi-Triki, Sylvie Schmidt, Aurélie Hirschler, Raony Guimaraes, Michael Simons, Anne Molitor, Francis Schneider, Damien Sanlaville, Thiên-Nga Chamaraux-Tran, Samira Fafi-Kremer, Pierre-Louis Tharaux, Thomas Chittenden, Angélique Pichot, A. Hanauer, Raphael Carapito, Mirjana Radosavljevic, Véronique Rolli, Bernard Goichot, Yvon Ruch, Olivier Collange, Ouria Tahar, Julien Pottecher, Khaldoun Kuteifan, Razieh Mohseninia, Perrine Spinnhirny, Alice Bernard, Bernard Drenou, Jean-Laurent Casanova, Elisa Pin, Jeffrey R. Gulcher, Paul-Michel Mertes, M. Javad Aman, Peter Nilsson, Jose Malagon-Lopez, François Danion, Yves Hansmann, Ferhat Meziani, Maleka Schenck, Nicodème Paul, Annabel Larnicol, Julia Frappier

Publikováno v: Science Translational Medicine
Science Translational Medicine, 2021, pp.1-59. ⟨10.1126/scitranslmed.abj7521⟩
Science Translational Medicine, American Association for the Advancement of Science, 2021, ⟨10.1126/scitranslmed.abj7521⟩

International audience; The etiopathogenesis of critical COVID-19 remains unknown. Indeed given major confounding factors (age and comorbidities), true drivers of this condition have remained elusive. Here, we employ an unprecedented multi-omics anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4c8db00ee20c68bec583014ad8e8e4
https://hal.science/hal-03436053

Ral GTPases promote metastasis by controlling biogenesis and organ colonization of exosomes

Autor: Marcel Blot-Chabaud, François Delalande, Shima Ghoroghi, Nicolas Vitale, Annick Klein, Laetitia Fouillen, Benjamin Mary, Coralie Spiegelhalter, Sébastien Halary, Nicodème Paul, Naël Osmani, Annabel Larnicol, Ignacio Busnelli, Jacky G. Goetz, Frédéric Gros, Julie Gavard, Anne-Marie Haeberlé, Raphael Carapito, Catherine A. Royer, Paul Timpson, Olivier Lefebvre, Gwennan André-Grégoire, Kendelle J. Murphy, Vincent Hyenne, Christine Carapito

International audience; Cancer extracellular vesicles (EVs) mainly exert pro-tumoral functions by changing the phenotypes of stromal cells to the benefit of tumor growth and metastasis. They shuttle to distant organs and fertilize pre-metastatic nich

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b5c40ebefaff80e5f2fb65451ccc75
https://hal.science/hal-02991406/file/2020.07.10.196691v1.full.pdf