Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Annabel, Borg"'
Autor:
Antoni G. Wrobel, Donald J. Benton, Chloë Roustan, Annabel Borg, Saira Hussain, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
The SARS-CoV-2 spike has been evolving in the human population. The variants of concern alpha and beta evolved to optimise spike openness and so ability to bind its receptor ACE2, the affinity towards the receptor, and stability upon receptor binding
Externí odkaz:
https://doaj.org/article/b4dd4e7327c04cb0a388bbe45794406e
Autor:
Antoni G. Wrobel, Donald J. Benton, Pengqi Xu, Lesley J. Calder, Annabel Borg, Chloë Roustan, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
It has been suggested that pangolin coronaviruses may be the origin of SARS-CoV-2. Here the authors show that the Pangolin-CoV spike is structurally closely related to the closed form of SARS-CoV-2 spike and exhibits similar binding properties to hum
Externí odkaz:
https://doaj.org/article/e6fc3e78a8f74f72b0f0a1e0880a8bb4
Autor:
Iván Plaza-Menacho, Karin Barnouin, Rachael Barry, Annabel Borg, Mariam Orme, Rakhee Chauhan, Stephane Mouilleron, Rubén J. Martínez-Torres, Pascal Meier, Neil Q. McDonald
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3319-3332 (2016)
Receptor tyrosine kinases exhibit a variety of activation mechanisms despite highly homologous catalytic domains. Such diversity arises through coupling of extracellular ligand-binding portions with highly variable intracellular sequences flanking th
Externí odkaz:
https://doaj.org/article/d79f670d6e0b48388c49a0287b96fbce
Autor:
Edgar Gonzalez-Rodriguez, Mia Zol-Hanlon, Ganka Bineva-Todd, Andrea Marchesi, Mark Skehel, Keira E. Mahoney, Chloë Roustan, Annabel Borg, Lucia Di Vagno, Svend Kjaer, Antoni G. Wrobel, Donald J. Benton, Philipp Nawrath, Sabine L. Flitsch, Dhira Joshi, Andrés Manuel González-Ramírez, Katalin A. Wilkinson, Robert J. Wilkinson, Emma C. Wall, Ramón Hurtado-Guerrero, Stacy A. Malaker, Benjamin Schumann
Publikováno v:
Gonzalez-Rodriguez, E, Zol-Hanlon, M, Bineva-Todd, G, Marchesi, A, Skehel, M, Mahoney, K E, Roustan, C, Borg, A, Di Vagno, L, Kjær, S, Wrobel, A G, Benton, D J, Nawrath, P, Flitsch, S L, Joshi, D, González-Ramírez, A M, Wilkinson, K A, Wilkinson, R J, Wall, E C, Hurtado-Guerrero, R, Malaker, S A & Schumann, B 2023, ' O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Likely Contribute to the Mutational Trajectory in Variants of Concern ', ACS Central Science, vol. 9, no. 3, pp. 393-404 . https://doi.org/10.1021/acscentsci.2c01349
The emergence of a polybasic cleavage motif for the protease furin in the SARS-CoV-2 spike protein has been established as a major factor for enhanced viral transmission in humans. The peptide region N-terminal to that motif is extensively mutated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8375bb070568530844a5ff77444ebaee
Autor:
John J. Skehel, Stephen R. Martin, A.G. Wrobel, Peter B. Rosenthal, Chloe Roustan, Saira Hussain, Annabel Borg, Steve Gamblin, D.J. Benton
Recently emerged variants of SARS-CoV-2 contain in their surface spike glycoproteins multiple substitutions associated with increased transmission and resistance to neutralising antibodies. We have examined the structure and receptor binding properti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741046cad28d5321ce3b490fbc6f2c74
Autor:
John J. Skehel, Annabel Borg, D.J. Benton, Pengqi Xu, Chloe Roustan, A.G. Wrobel, Peter B. Rosenthal, Stephen R. Martin, S.J. Gamblin
Publikováno v:
Proceedings of the National Academy of Sciences. 118
The authors note that on page 3, left column, first paragraph, line 5, “K848” should instead appear as “K854.” The online version has been corrected.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c23cee70a0c975ec6644acd27f5599ec
https://doi.org/10.1073/pnas.2112850118
https://doi.org/10.1073/pnas.2112850118
Autor:
Edward J Carr, Mary Wu, Ruth Harvey, Emma C Wall, Gavin Kelly, Saira Hussain, Michael Howell, George Kassiotis, Charles Swanton, Sonia Gandhi, David LV Bauer, Roseanne E Billany, Matthew PM Graham-Brown, Joseph Beckett, Katherine Bull, Sushma Shankar, Scott Henderson, Reza Motallebzadeh, Alan D Salama, Lorraine Harper, Patrick B Mark, Stephen McAdoo, Michelle Willicombe, Rupert Beale, Sherna F Adenwalla, Paul Bird, Christopher Holmes, Katherine L Hull, Daniel S March, Haresh Selvaskandan, Jorge J Silva, Julian W Tang, Joanna Hester, Fadi Issa, Martin Barnardo, Peter J Friend, Andrew Davenport, Catriona Goodlad, Vignesh Gopalan, Theerasak Tangwonglert, Hans J Stauss, Alex G Richter, Adam F Cunningham, Marisol Perez-Toledo, Gemma D Banham, Nadya Wall, Candice L Clarke, Maria Prendecki, Bobbi Clayton, Sina Namjou, Vanessa Silva, Meghan Poulten, Philip Bawumia, Murad Miah, Samuel Sade, Mauro Miranda, Tom Taylor, Ilenia D'Angelo, Mercedes Cabrera Jarana, Mahbubur Rahman, Janet Abreu, Sandeep Sandhar, Neil Bailey, Simon Caidan, Marie Caulfield, Lorin Adams, Caitlin Kavanagh, Scott Warchal, Chelsea Sawyer, Mike Gavrielides, Jag Kandasamy, Karen Ambrose, Amy Strange, Titilayo Abiola, Nicola O'Reilly, Philip Hobson, Ana Agau-Doce, Emma Russell, Andrew Riddell, Svend Kjaer, Annabel Borg, Chloë Roustan
Publikováno v:
Lancet (London, England)
No abstract available.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d83aa5ff3b319e6b5ba40ea8550d864
https://pubmed.ncbi.nlm.nih.gov/35065703
https://pubmed.ncbi.nlm.nih.gov/35065703
Autor:
Safia Deddouche, Delphine Goubau, Jan Rehwinkel, Probir Chakravarty, Sharmin Begum, Pierre V Maillard, Annabel Borg, Nik Matthews, Qian Feng, Frank J M van Kuppeveld, Caetano Reis e Sousa
Publikováno v:
eLife, Vol 3 (2014)
The RIG-I-like receptors RIG-I, LGP2, and MDA5 initiate an antiviral response that includes production of type I interferons (IFNs). The nature of the RNAs that trigger MDA5 activation in infected cells remains unclear. Here, we purify and characteri
Externí odkaz:
https://doaj.org/article/663aa2a635a647259cca6a484c5c450c
Autor:
John W. McCauley, Ruth Harvey, Mary Wu, Laura E. McCoy, Agustina P Bertolin, Viktor Posse, Rupert Beale, Lucy S. Drury, John F.X. Diffley, Svend Kjaer, Saira Hussain, Berta Canal, Annabel Borg, Florian Weissmann, Jingkun Zeng, Jennifer C. Milligan, Rachel Ulferts, Michael Howell, Chloe Roustan
Publikováno v:
Biochemical Journal
SummaryThe coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global public health challenge. While the efficacy of vaccines against emerging and future virus variants re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2be294aa30a2fa0bdf7de7e17f9f7f6
https://doi.org/10.1101/2021.04.07.438808
https://doi.org/10.1101/2021.04.07.438808
Autor:
Chloe Roustan, D.J. Benton, Lesley J. Calder, Pengqi Xu, Steven J. Gamblin, A.G. Wrobel, John J. Skehel, Peter B. Rosenthal, Stephen R. Martin, Annabel Borg
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce10e9268e5996e9a577957d2556f96c
https://doi.org/10.1038/s41467-021-21006-9
https://doi.org/10.1038/s41467-021-21006-9