Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Anna-Sophia Kiang"'
Autor:
Paul S. Cassidy, Ruth A. Kelly, Ester Reina-Torres, Joseph M. Sherwood, Marian M. Humphries, Anna-Sophia Kiang, G. Jane Farrar, Colm O’Brien, Matthew Campbell, W. Daniel Stamer, Darryl R. Overby, Pete Humphries, Jeffrey O’Callaghan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 86-94 (2021)
Systemic or localized application of glucocorticoids (GCs) can lead to iatrogenic ocular hypertension, which is a leading cause of secondary open-angle glaucoma and visual impairment. Previous work has shown that dexamethasone increases zonula occlud
Externí odkaz:
https://doaj.org/article/d2e3a1e4567a46bd80bb688a8be4ad9b
Autor:
Paul F Kenna, Marian M Humphries, Anna-Sophia Kiang, Philippe Brabet, Laurent Guillou, Ema Ozaki, Matthew Campbell, G Jane Farrar, Robert Koenekoop, Pete Humphries
Publikováno v:
BMJ Open Ophthalmology, Vol 5, Iss 1 (2020)
Objectives No therapeutic interventions are currently available for autosomal dominant retinitis pigmentosa (adRP). An RPE65 Asp477Gly transition associates with late-onset adRP, reduced RPE65 enzymatic activity being one feature associated with this
Externí odkaz:
https://doaj.org/article/b2c508a232bf43a1be3e4db852091f21
Autor:
Ester Reina-Torres, Peter Humphries, Darryl R. Overby, Paul S. Cassidy, W. Daniel Stamer, Marian M. Humphries, Jeffrey O'Callaghan, Joseph M. Sherwood, Anna-Sophia Kiang, Ruth Kelly, Colm O'Brien, Matthew Campbell, G. Jane Farrar
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 86-94 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 86-94 (2021)
Systemic or localized application of glucocorticoids (GCs) can lead to iatrogenic ocular hypertension, which is a leading cause of secondary open-angle glaucoma and visual impairment. Previous work has shown that dexamethasone increases zonula occlud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d96030b233c2e907f8ad458182e77e
https://doi.org/10.1016/j.omtm.2020.10.022
https://doi.org/10.1016/j.omtm.2020.10.022
Autor:
Philippe Brabet, Peter Humphries, Marian M. Humphries, Paul F. Kenna, Robert K. Koenekoop, Ema Ozaki, G. Jane Farrar, Matthew Campbell, Anna Sophia Kiang, Laurent Guillou
Publikováno v:
BMJ Open Ophthalmology
BMJ Open Ophthalmology, Vol 5, Iss 1 (2020)
BMJ Open Ophthalmology, Vol 5, Iss 1 (2020)
ObjectivesNo therapeutic interventions are currently available for autosomal dominant retinitis pigmentosa (adRP). An RPE65 Asp477Gly transition associates with late-onset adRP, reduced RPE65 enzymatic activity being one feature associated with this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be29a9576cca576a0871e3c70a43ec0
https://pubmed.ncbi.nlm.nih.gov/32426524
https://pubmed.ncbi.nlm.nih.gov/32426524
Autor:
Anna Sophia Kiang, Sophia Millington-Ward, Marian M. Humphries, G. Jane Farrar, Adrian Dockery, Peter Humphries, Naomi Chadderton, Matthew Carrigan, Arpad Palfi, Paul F. Kenna
Publikováno v:
Human Molecular Genetics
While individually classed as rare diseases, hereditary retinal degenerations (IRDs) are the major cause of registered visual handicap in the developed world. Given their hereditary nature, some degree of intergenic heterogeneity was expected, with g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51257325889dadb419c3bef3fb5ec2e5
https://doi.org/10.1093/hmg/ddx185
https://doi.org/10.1093/hmg/ddx185
Autor:
Matthew Campbell, Joseph M. Sherwood, Elke Lütjen-Drecoll, Lawrence C. S. Tam, Cassandra Flügel-Koch, Colm O'Brien, Deborah Wallace, Anna-Sophia Kiang, Paul S. Cassidy, Ester Reina-Torres, Peter Humphries, Jeffrey O'Callaghan, Darryl R. Overby, W. Daniel Stamer, Marian M. Humphries, Darragh E. Crosbie
Publikováno v:
Human Molecular Genetics
Intraocular pressure (IOP) is maintained as a result of the balance between production of aqueous humour (AH) by the ciliary processes and hydrodynamic resistance to its outflow through the conventional outflow pathway comprising the trabecular meshw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966c41a295e4ceb2c6683ddf2fdd17ec
https://doi.org/10.1093/hmg/ddx028
https://doi.org/10.1093/hmg/ddx028
Autor:
Robert K. Koenekoop, Peter Humphries, Anna-Sophia Kiang, Marian M. Humphries, G. Jane Farrar, Matthew Campbell, Ema Ozaki, Paul F. Kenna
Publikováno v:
Genes
Genes, Vol 11, Iss 1420, p 1420 (2020)
Genes, Vol 11, Iss 1420, p 1420 (2020)
RPE65 isomerase, expressed in the retinal pigmented epithelium (RPE), is an enzymatic component of the retinoid cycle, converting all-trans retinyl ester into 11-cis retinol, and it is essential for vision, because it replenishes the photon capturing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca8c95d3346b57065b3f1669c8c510e
https://doi.org/10.3390/genes11121420
https://doi.org/10.3390/genes11121420
Autor:
Darragh E. Crosbie, Anna-Sophia Kiang, Matthew S. Lawrence, Elke Lütjen-Drecoll, Colm O'Brien, Jeffrey O'Callaghan, Kristin Perkumas, Ester Reina-Torres, W. Daniel Stamer, Marian M. Humphries, Joseph M. Sherwood, Matthew Campbell, John J. Callanan, Lawrence C. S. Tam, Darryl R. Overby, Cassandra Flügel-Koch, Peter Humphries, Paul S. Cassidy, A. Thomas Read, C. Ross Ethier
Publikováno v:
Scientific Reports
The juxtacanalicular connective tissue of the trabecular meshwork together with inner wall endothelium of Schlemm’s canal (SC) provide the bulk of resistance to aqueous outflow from the anterior chamber. Endothelial cells lining SC elaborate tight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fc806f8671f157845801d0b0cd1bf6
https://pubmed.ncbi.nlm.nih.gov/28091584
https://pubmed.ncbi.nlm.nih.gov/28091584
Autor:
Ed C. Lavelle, Ema Ozaki, Robert G. Salomon, Gwyneth Jane Farrar, Sarah L. Doyle, Marian M. Humphries, Peter Humphries, Matthew Campbell, Andres Mori, Anna Sophia Kiang, Joe G. Hollyfield, Paul F. Kenna, Luke A. J. O'Neill
Publikováno v:
Nature Medicine. 18:791-798
Age-related macular degeneration (AMD) is the leading cause of central vision loss worldwide. Drusen accumulation is the major pathological hallmark common to both dry and wet AMD. Although activation of the immune system has been implicated in disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b046e94604da7931592e5640c41b116
https://doi.org/10.1038/nm.2717
https://doi.org/10.1038/nm.2717
Autor:
Mayu Suzuki, Paul F. Kenna, Peter Humphries, Oliviero L. Gobbo, G. Jane Farrar, Marian M. Humphries, Lawrence C. S. Tam, Anna-Sophia Kiang, Anh T. H. Nguyen, Matthew Campbell, Ema Ozaki, Finnian Hanrahan
Publikováno v:
EMBO Molecular Medicine
We describe a procedure for controlled, periodic, reversible modulation of selected regions of the blood–brain barrier (BBB) or the inner-blood–retina barrier (iBRB) based on incorporation into an AAV-2/9 vector of a doxycycline-inducible gene en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17677600075c06f6cdc52fb6f320a8b
http://europepmc.org/articles/PMC3377070
http://europepmc.org/articles/PMC3377070