Correction: A two-lane mechanism for selective biological ammonium transport

Autor: Gordon Williamson, Giulia Tamburrino, Adriana Bizior, Mélanie Boeckstaens, Gaëtan Dias Mirandela, Marcus G Bage, Andrei Pisliakov, Callum M Ives, Eilidh Terras, Paul A Hoskisson, Anna-Maria Marini, Ulrich Zachariae, Arnaud Javelle

Publikováno v: eLife, Vol 11 (2022)

Externí odkaz: https://doaj.org/article/d473114dae45473a97860d445de6cabc

Tetrahydroquinazole-based secondary sulphonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IV, and IX, and computational studies

Autor: Emma Baglini, Rahul Ravichandran, Emanuela Berrino, Silvia Salerno, Elisabetta Barresi, Anna Maria Marini, Monica Viviano, Sabrina Castellano, Federico Da Settimo, Claudiu T. Supuran, Sandro Cosconati, Sabrina Taliani

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1874-1883 (2021)

A library of variously decorated N-phenyl secondary sulphonamides featuring the bicyclic tetrahydroquinazole scaffold was synthesised and biologically evaluated for their inhibitory activity against human carbonic anhydrase (hCA) I, II, IV, and IX. O

Externí odkaz: https://doaj.org/article/88031813ab9443118c310ad8a0e3ccdb

Pib2-Dependent Feedback Control of the TORC1 Signaling Network by the Npr1 Kinase

Autor: Ana Sofia Brito, Silvia Soto Diaz, Pascale Van Vooren, Patrice Godard, Anna Maria Marini, Mélanie Boeckstaens

Publikováno v: iScience, Vol 20, Iss , Pp 415-433 (2019)

Summary: To adjust cell growth and metabolism according to environmental conditions, the conserved TORC1 signaling network controls autophagy, protein synthesis, and turnover. Here, we dissected the signals controlling phosphorylation and activity of

Externí odkaz: https://doaj.org/article/86916cfaa7fe4f7d832e58e9a7d2eff7

Carbonic anhydrase activation profile of indole-based derivatives

Autor: Federico Da Settimo, Sandro Cosconati, Claudia Martini, Eleonora Da Pozzo, Claudiu T. Supuran, Andrea Angeli, Elisabetta Barresi, Barbara Costa, Lorenzo Germelli, Rahul Ravichandran, Emma Baglini, Silvia Salerno, Sabrina Taliani, Anna Maria Marini

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1783-1797 (2021)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record

Carbonic Anhydrase Activators (CAAs) could represent a novel approach for the treatment of Alzheimer’s disease, ageing, and other conditions that require remedial achievement of spatial learning and memory therapy. Within a research project aimed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ab3f3c620e14b64aa7da5388937e37
https://doaj.org/article/61803acb569c43b59486f5dce895777a

Characterisation of the Rh50 protein from the ammonia-oxidising bacterium Nitrosomonas europaea

Autor: Adriana Bizior, Gordon Williamson, Gaëtan Dias Mirandela, Mélanie Boeckstaens, Paul Hoskisson, Anna Maria Marini, Ulrich Zachariae, Arnaud Javelle

Publikováno v: Access Microbiology. 4

The transport of ammonium through the cell membranes, an essential process in all kingdoms of life, is accomplished by the ubiquitous Amt/Mep/Rh superfamily of proteins. The functional context of Amt/Mep and Rh transporters is diverse: bacteria, fung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49abb8c96e8d01855902bfefc5de5d19
https://doi.org/10.1099/acmi.ac2021.po0269