Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo

Autor: Timo T. Myöhänen, Marjo Piltonen, O. Leskelä, P. Auvinen, Kari Alitalo, Anu Planken, Mart Saarma, Anna-Liisa Hänninen, Pekka T. Männistö, Jaan-Olle Andressoo

Publikováno v: Neuroscience. 192:550-563

Neurotrophic factors regulate the development and maintenance of the nervous system and protect and repair dopaminergic neurons in animal models of Parkinson's disease (PD). Vascular endothelial growth factors A (VEGF-A) and B have also neurotrophic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab57bec84b31772aafcfff23a1d1052d
https://doi.org/10.1016/j.neuroscience.2011.06.084

Enabling Low Cost Biopharmaceuticals: A Systematic Approach to Delete Proteases from a Well-Known Protein Production Host Trichoderma reesei

Autor: Merja Penttilä, Juhani Saarinen, Christopher P. Landowski, Anne Kanerva, Jari Natunen, Bernhard Helk, Markku Saloheimo, Noora Salovuori, Christian Ostermeier, Ann Westerholm-Parvinen, Anna-Liisa Hänninen, Anne Huuskonen, Ramon Wahl

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134723 (2015)
PLoS ONE
Landowski, C P, Huuskonen, A, Wahl, R, Westerholm-Parvinen, A, Kanerva, A, Hänninen, A-L, Salovuori, N, Penttilä, M, Natunen, J, Ostermeier, C, Helk, B, Saarinen, J & Saloheimo, M 2015, ' Enabling low cost biopharmaceuticals : A systematic approach to delete proteases from a well-known protein production host trichoderma reesei ', PLoS ONE, vol. 10, no. 8, e0134723 . https://doi.org/10.1371/journal.pone.0134723

The filamentous fungus Trichoderma reesei has tremendous capability to secrete proteins. Therefore, it would be an excellent host for producing high levels of therapeutic proteins at low cost. Developing a filamentous fungus to produce sensitive ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1db175b1160d9924a75b457e676886
http://europepmc.org/articles/PMC4550459?pdf=render

The Cytoplasmic Chaperone Hsp104 Is Required for Conformational Repair of Heat-denatured Proteins in the Yeast Endoplasmic Reticulum

Autor: Nina Saris, Mari Simola, Marja Makarow, Anna-Liisa Hänninen

Publikováno v: Scopus-Elsevier

Severe heat stress causes protein denaturation in various cellular compartments. If Saccharomyces cerevisiae cells grown at 24 degrees C are preconditioned at 37 degrees C, proteins denatured by subsequent exposure to 48-50 degrees C can be renatured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e3b1f588f1f317eef05b39519db0a2
https://doi.org/10.1091/mbc.10.11.3623

Assembly of Membrane-Containing Bacteriophage PRD1 Is Dependent on GroEL and GroES

Autor: Anna-Liisa Hänninen, Jaana K. H. Bamford, Dennis H. Bamford

Publikováno v: Virology. 227:207-210

Assembly of the broad-host-range bacteriophage PRD1 involves translocation of the virus-specific membrane to the inside of the icosahedral protein shell formed of trimeric coat proteins. The formation of PRD1 particles is, in addition to the virus-en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558a4c7b90fddf09ba1b6c6871a147cb
https://doi.org/10.1006/viro.1996.8308

Production of heterologous proteins in yeast with the aid of the Hsp150delta carrier

Autor: Marja, Makarow, Anna-Liisa, Hänninen, Taina, Suntio, Ricardo Nunes, Bastos

Publikováno v: Methods in molecular biology (Clifton, N.J.). 313

Proper folding, and consequently exit from the endoplasmic reticulum (ER) and secretion of heterologous exocytic proteins in yeast can be rescued by fusing the proteins to certain yeast-derived polypeptides. Biologically active mammalian glycoprotein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b7ccee9178a9516016e0b7ffd3b11ad
https://pubmed.ncbi.nlm.nih.gov/16118442