Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Anna-Lena Volckmar"'
Autor:
Michael Menzel, Martina Kirchner, Klaus Kluck, Markus Ball, Susanne Beck, Michael Allgäuer, Christin Assmann, Johannes Schnorbach, Anna‐Lena Volckmar, Timothy Kwang Yong Tay, Hannah Goldschmid, Daniel SW Tan, Michael Thomas, Daniel Kazdal, Jan Budczies, Albrecht Stenzinger, Petros Christopoulos
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 2, Pp n/a-n/a (2024)
Abstract This study analyzed whether extended molecular profiling can predict the development of epidermal growth factor receptor (EGFR) gene T790M mutation, which is the most frequent resistance alteration in non‐small cell lung cancer (NSCLC) aft
Externí odkaz:
https://doaj.org/article/592032d0cf624a62bd5f0cb57fe2198c
Autor:
Olaf Neumann, Ulrich Lehmann, Stephan Bartels, Nicole Pfarr, Thomas Albrecht, Katharina Ilm, Jens Christmann, Anna‐Lena Volckmar, Hannah Goldschmid, Martina Kirchner, Michael Allgäuer, Maria Walker, Hans Kreipe, Andrea Tannapfel, Wilko Weichert, Peter Schirmacher, Daniel Kazdal, Albrecht Stenzinger
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 2, Pp 100-107 (2023)
Abstract Intrahepatic cholangiocarcinoma harbours druggable genetic lesions including FGFR2 gene fusions. Reliable and accurate detection of these fusions is becoming a critical component of the molecular work‐up, but real‐world data on the perfo
Externí odkaz:
https://doaj.org/article/766fefd6743746f48f23bf3da053da40
Autor:
Luisa Sophie Rajcsanyi, Inga Diebels, Lydia Pastoors, Deniz Kanber, Triinu Peters, Anna-Lena Volckmar, Yiran Zheng, Martin Grosse, Christoph Dieterich, Johannes Hebebrand, Frank J. Kaiser, Bernhard Horsthemke, Anke Hinney
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Circular RNAs (circRNAs) are regulators of processes like adipogenesis. Their expression can be modulated by SNPs. We analysed links between BMI-associated SNPs and circRNAs. First, we detected an enrichment of BMI-associated SNPs on circRNA
Externí odkaz:
https://doaj.org/article/1cd7ead5088847afa8cbf877939db6c3
Autor:
Miriam Blasi, Daniel Kazdal, Michael Thomas, Petros Christopoulos, Mark Kriegsmann, Regine Brandt, Anna-Lena Volckmar, Martina Kirchner, Claus Peter Heußel, Albrecht Stenzinger, Jonas Kuon
Publikováno v:
Case Reports in Oncology, Vol 14, Iss 1, Pp 477-482 (2021)
Tyrosine kinase inhibitors (TKIs) represent the standard treatment for patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. The duration of the response is, however, limited in time owing to th
Externí odkaz:
https://doaj.org/article/049d3a8ec4694a42a85b80a3d2b2959f
Autor:
Lea Daniello, Mariam Elshiaty, Farastuk Bozorgmehr, Jonas Kuon, Daniel Kazdal, Hannah Schindler, Rajiv Shah, Anna-Lena Volckmar, Fabienne Lusky, Leonore Diekmann, Stephan Liersch, Martin Faehling, Thomas Muley, Mark Kriegsmann, Karolina Benesova, Albrecht Stenzinger, Michael Thomas, Petros Christopoulos
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
IntroductionPD-(L)1 inhibitors have improved prognosis of non-small-cell lung cancer (NSCLC), but can also cause immune-related adverse events (irAEs) that complicate management.MethodsWe analyzed NSCLC patients receiving PD-(L)1 inhibitors from 2012
Externí odkaz:
https://doaj.org/article/efcf15f6bb524a57ab253477dc483ce6
Autor:
Mei Elsayed, Farastuk Bozorgmehr, Daniel Kazdal, Anna-Lena Volckmar, Holger Sültmann, Jürgen R. Fischer, Mark Kriegsmann, Albrecht Stenzinger, Michael Thomas, Petros Christopoulos
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundAnaplastic lymphoma kinase-rearranged non-small-cell lung cancer (ALK+ NSCLC) is a model disease for use of targeted therapies (TKI), which are administered sequentially to maximize patient survival.MethodsWe retrospectively analyzed the fl
Externí odkaz:
https://doaj.org/article/038fbb4cc1074b41b5ddf206f987ab04
Autor:
Nikolaus Magios, Farastuk Bozorgmehr, Anna-Lena Volckmar, Daniel Kazdal, Martina Kirchner, Felix J. Herth, Claus-Peter Heussel, Florian Eichhorn, Michael Meister, Thomas Muley, Rami A. Elshafie, Jürgen R. Fischer, Martin Faehling, Mark Kriegsmann, Peter Schirmacher, Helge Bischoff, Albrecht Stenzinger, Michael Thomas, Petros Christopoulos
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 13 (2021)
Background: Epidermal growth factor receptor-mutated (EGFR + ) non-small-cell lung cancer (NSCLC) patients failing tyrosine kinase inhibitors (TKI) can benefit from next-line targeted therapies, but implementation is challenging. Methods: EGFR + NSCL
Externí odkaz:
https://doaj.org/article/cc0d2140121c4e9798dd4c51c532b090
Autor:
Steffen Dietz, Petros Christopoulos, Zhao Yuan, Arlou Kristina Angeles, Lisa Gu, Anna-Lena Volckmar, Simon J. Ogrodnik, Florian Janke, Chiara Dalle Fratte, Tomasz Zemojtel, Marc A. Schneider, Daniel Kazdal, Volker Endris, Michael Meister, Thomas Muley, Erika Cecchin, Martin Reck, Matthias Schlesner, Michael Thomas, Albrecht Stenzinger, Holger Sültmann
Publikováno v:
EBioMedicine, Vol 62, Iss , Pp 103103- (2020)
Background: Targeted therapies (TKI) have improved the prognosis of ALK-rearranged lung cancer (ALK+ NSCLC), but clinical courses vary widely. Early identification and molecular characterisation of treatment failure have key importance for subsequent
Externí odkaz:
https://doaj.org/article/35543e5f53e748e782b1be948db8ee4b
Autor:
Nikolas Herrfurth, Anna-Lena Volckmar, Triinu Peters, Gunnar Kleinau, Anne Müller, Cigdem Cetindag, Laura Schonnop, Manuel Föcker, Astrid Dempfle, Stefan A. Wudy, Struan F. A. Grant, Thomas Reinehr, Diana L. Cousminer, Johannes Hebebrand, Heike Biebermann, Anke Hinney
Publikováno v:
BMC Pediatrics, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background Variation in genes of the leptinergic-melanocortinergic system influence both body weight and height. Because short normal stature (SNS) is characterized by reduced body height, delayed maturation and leanness, allelic variation o
Externí odkaz:
https://doaj.org/article/2c96f42edfff4ac49c1930a38bac7a91
Autor:
Johanna Giuranna, Anna-Lena Volckmar, Anna Heinen, Triinu Peters, Börge Schmidt, Anne Spieker, Helena Straub, Harald Grallert, Timo D. Müller, Jochen Antel, Ute Haußmann, Hans Klafki, Rui Liangyou, Johannes Hebebrand, Anke Hinney
Publikováno v:
Obesity Facts, Vol 11, Iss 2, Pp 93-108 (2018)
Objective: We aimed to determine the effect of human SH2B1 variants on leptin and insulin signaling, which are major regulators of energy homeostasis, on the RNA level. Methods: We analyzed the expression of infrequent alleles of seven SH2B1 variants
Externí odkaz:
https://doaj.org/article/46de7f0510914b3f8e715b0c94aa8102