Interleukin-36 in Infectious and Inflammatory Skin Diseases

Autor: Anna-Lena Buhl, Joerg Wenzel

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Interleukin-36 (IL-36) comprises to a cytokine family consisting of four isoforms IL-36α, IL-36β, IL-36γ, and IL-36 receptor antagonist (IL-36 Ra). These IL-36 cytokines, in turn, belong to the IL-1 superfamily. The IL-36 receptor (IL-1R6) is func

Externí odkaz: https://doaj.org/article/f059412504604b4db0fed7b5c144b2ab

The Proinflammatory Cytokine IL-36γ Is a Global Discriminator of Harmless Microbes and Invasive Pathogens within Epithelial Tissues

Autor: Martin Stacey, Paul Bowyer, Joerg Wenzel, Miriam Wittmann, Tom Macleod, Sebastian Konzok, Armin Braun, Joseph S. Ainscough, Yutaka Terao, Anna-Lena Buhl, Christina Hesse, Sarah E. Herrick

Publikováno v: Cell Reports
Cell Reports, Vol 33, Iss 11, Pp 108515-(2020)
Macleod, T, Ainscough, J S, Hesse, C, Konzok, S, Braun, A, Buhl, A-L, Wenzel, J, Bowyer, P, Terao, Y, Herrick, S, Wittmann, M & Stacey, M 2020, ' The Proinflammatory Cytokine IL-36γ Is a Global Discriminator of Harmless Microbes and Invasive Pathogens within Epithelial Tissues ', Cell Reports, vol. 33, no. 11, 108515, pp. 1-12.e3 . https://doi.org/10.1016/j.celrep.2020.108515
Macleod, T, Ainscough, J, Hesse, C, Konzok, S, Braun, A, Buhl, A-L, Wenzel, J, Bowyer, P, Terao, Y, Herrick, S, Wittmann, M & Stacey, M 2020, ' The Proinflammatory Cytokine IL-36γ Is a Global Discriminator of Harmless Microbes and Invasive Pathogens within Epithelial Tissues ', Cell Reports, vol. 33, no. 11, pp. 1-12.e3 . https://doi.org/10.1016/j.celrep.2020.108515

Summary Epithelial tissues represent vital interfaces between organisms and their environment. As they are constantly exposed to harmful pathogens, innocuous commensals, and environmental microbes, it is essential they sense and elicit appropriate re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0389c3e40ffad6e0feee0ac5ee096a
https://pubmed.ncbi.nlm.nih.gov/33326792