Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Anna-Klara Rundlöf"'
Autor:
Katalin Monostory, Lena Ekström, Maria Johansson, Elias S.J. Arnér, Anna Klara Rundlöf, Linda Björkhem-Bergman
Publikováno v:
Biochemical and Biophysical Research Communications. 430:90-94
Thioredoxin reductase 1 (TrxR1) is a selenocysteine-containing redox-active enzyme that is thought to be important during carcinogenesis. We have recently shown that treatment with statins, HMGCoA reductase inhibitors, reduces the levels of TrxR1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8b2a882c29ef026273d9dc9f1fa7a6
https://doi.org/10.1016/j.bbrc.2012.11.007
https://doi.org/10.1016/j.bbrc.2012.11.007
Autor:
Anna Citta, Alessandra Folda, Aristi P. Fernandes, Cristina Marzano, Valentina Gandin, Anna-Klara Rundlöf, Maria Pia Rigobello, Mikael Björnstedt, Guido Scutari, Alberto Bindoli
Publikováno v:
Free Radical Biology and Medicine. 50:1620-1629
The interactions of selenite and tellurite with cytosolic and mitochondrial thioredoxin reductases (TrxR1 and TrxR2) and glutathione reductases (GR) from yeast and mammalian sources were explored. Both TrxR1 and TrxR2 act as selenite and tellurite re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13d98c84bb54927f337795d866a1ca9
https://doi.org/10.1016/j.freeradbiomed.2011.03.006
https://doi.org/10.1016/j.freeradbiomed.2011.03.006
Publikováno v:
Antioxidants & Redox Signaling. 12:867-880
Selenium is an essential element that is specifically incorporated as selenocystein into selenoproteins. It is a potent modulator of eukaryotic cell growth with strictly concentration-dependant effects. Lower concentrations are necessary for cell sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3991edd5e45d0a3da404d8d671815e2c
https://doi.org/10.1089/ars.2009.2884
https://doi.org/10.1089/ars.2009.2884
Autor:
Sören Lehmann, Aristi P. Fernandes, Anna-Klara Rundlöf, Inmaculada Ribera-Cortada, Lennart Eriksson, Mikael Björnstedt, Eric Olm, Kerstin Jönsson-Videsäter, C. Paul
Publikováno v:
Cancer Letters. 282:116-123
Selenite is a potent inhibitor of malignant cell growth. Although the cytotoxic effects have been extensively investigated in vitro, there are only a limited number of studies using primary tumor cells with concomitant comparison to conventional drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5853e8e0411b4c67ee84a570e5679d66
https://doi.org/10.1016/j.canlet.2009.03.010
https://doi.org/10.1016/j.canlet.2009.03.010
Autor:
Anna-Klara Rundlöf, Aristi P. Fernandes, Mikael Björnstedt, Erik Huusfeldt Larsen, Christina Hebert, Olof Danielsson, Eric Olm
Publikováno v:
Proceedings of the National Academy of Sciences. 106:11400-11405
The selenium salt selenite (SeO 3 2− ) is cytotoxic in low to moderate concentrations, with a remarkable specificity for cancer cells resistant to conventional chemotherapy. Our data show that selenium uptake and accumulation, rather than intracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82809c2363f7f794437f9ecc6e7ea8d0
https://doi.org/10.1073/pnas.0902204106
https://doi.org/10.1073/pnas.0902204106
Effects of the antioxidant Pycnogenol® on cellular redox systems in U1285 human lung carcinoma cells
Autor:
Kerstin Jönsson-Videsäter, Frank Schönlau, Valentina Gandin, Aristi P. Fernandes, Anna-Klara Rundlöf, Mikael Björnstedt, Christina Nyström, Jarmo Hörkkö
Publikováno v:
FEBS Journal. 276:532-540
Pycnogenol, which is extracted from the bark of French maritime pine, has been shown to have antioxidant and free radical scavenging activities. Thioredoxin reductase (TrxR), glutathione peroxidase (GPx) and glutathione reductase (GR) are three centr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f046762a763dd267df80c0d284c2aed1
https://doi.org/10.1111/j.1742-4658.2008.06800.x
https://doi.org/10.1111/j.1742-4658.2008.06800.x
Publikováno v:
Biochemical Pharmacology. 75:2092-2099
Selenium at subtoxic doses has been shown to have tumor specific cytotoxic effects. In this work, viability measurements in different lung cancer cell lines showed that selenite was more effective compared to three different conventional cytotoxic dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5ecec3fb8b71ecad6b0e5364a3975e
https://doi.org/10.1016/j.bcp.2008.02.028
https://doi.org/10.1016/j.bcp.2008.02.028
Autor:
Anna-Klara Rundlöf, Fergus Nicol, Elias S.J. Arnér, Lynne K. Crosley, John E. Hesketh, John R. Arthur, Catherine Méplan
Publikováno v:
Archives of Biochemistry and Biophysics. 459:178-188
Adequate supply of selenium (Se) is critical for synthesis of selenoproteins through selenocysteine insertion mechanism. To explore this process we investigated the expression of the cytosolic and mitochondrial isoenzymes of thioredoxin reductase (Tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d3fca704a8065151dfc3751be4f5a4
https://doi.org/10.1016/j.abb.2006.12.029
https://doi.org/10.1016/j.abb.2006.12.029
Autor:
Aristi P. Fernandes, Katalin Dobra, Leopold L. Ilag, Gustav Nilsonne, Mikael Björnstedt, Mia Babic, Anna-Klara Rundlöf, Markus Selenius, Mohammadreza Shariatgorji
Publikováno v:
Differentiation. 75:123-132
The human selenoenzyme thioredoxin reductase 1 (TrxR1) is a very important enzyme for cell growth, differentiation, and the defense against oxidative stress. Several studies have shown that TrxR1 is up-regulated in tumor cells. The regulation of TrxR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39a8d9cb37700b1b995ab86f0846937
https://doi.org/10.1111/j.1432-0436.2006.00121.x
https://doi.org/10.1111/j.1432-0436.2006.00121.x
Publikováno v:
Journal of Biological Chemistry. 276:30542-30551
The selenoprotein thioredoxin reductase 1 (TrxR1) carries many vital antioxidant and redox regulatory functions. Its mRNA levels are known to be post-transcriptionally modulated via AUUUA motifs (AU-rich elements (AREs)), but the promoter yet remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fa4acb8d090872bde15c58ae3875e46
https://doi.org/10.1074/jbc.m101452200
https://doi.org/10.1074/jbc.m101452200