Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Anna-Katharina Wirth"'
Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo
Autor:
Ehsan Bahrami, Jan Philipp Schmid, Vindi Jurinovic, Martin Becker, Anna-Katharina Wirth, Romina Ludwig, Sophie Kreissig, Tania Vanessa Duque Angel, Diana Amend, Katharina Hunt, Rupert Öllinger, Roland Rad, Joris Maximilian Frenz, Maria Solovey, Frank Ziemann, Matthias Mann, Binje Vick, Christian Wichmann, Tobias Herold, Ashok Kumar Jayavelu, Irmela Jeremias
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-19 (2023)
Abstract Background Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells. Methods To identify responsible surface proteins,
Externí odkaz:
https://doaj.org/article/66f5c76d28b54ed08739c0260b297b46
Autor:
Wen-Hsin Liu, Paulina Mrozek-Gorska, Anna-Katharina Wirth, Tobias Herold, Larissa Schwarzkopf, Dagmar Pich, Kerstin Völse, M. Camila Melo-Narváez, Michela Carlet, Wolfgang Hammerschmidt, Irmela Jeremias
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-15 (2020)
Abstract Background Clinically relevant methods are not available that prioritize and validate potential therapeutic targets for individual tumors, from the vast amount of tumor descriptive expression data. Methods We established inducible transgene
Externí odkaz:
https://doaj.org/article/959c31577ec848568d189cab46db5c31
Autor:
Carsten Müller-Tidow, Andreas Trumpp, Roland Beckmann, Irmela Jeremias, Jeroen Krijgsveld, Simon Raffel, Michaela Frye, Claudia Baldus, Christian Thiede, Martin Bornhäuser, Christoph Röllig, Hubert Serve, Thomas Oellerich, Tim Sauer, Caroline Pabst, Xiaobing Yu, Haiyang Yun, Michelle Lotze, Stefanie Göllner, Daria Fijalkowska, Anna-Katharina Wirth, Jingdong Cheng, Christian Rohde, Yi Liu, Nesrine Aroua, Fengbiao Zhou
Supplementary Figure S1 shows enrichment of FBL in LSC, correlation of FBL with LSC signature and rRNA 2'-O-Me in healthy hematopoietic cells. Supplementary Figure S2 shows the association of rRNA 2’-O-Me with LSC and hematopoietic differentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b89d549b025597d55ff3cbc4fa018ff
https://doi.org/10.1158/2159-8290.22541986
https://doi.org/10.1158/2159-8290.22541986
Autor:
Carsten Müller-Tidow, Andreas Trumpp, Roland Beckmann, Irmela Jeremias, Jeroen Krijgsveld, Simon Raffel, Michaela Frye, Claudia Baldus, Christian Thiede, Martin Bornhäuser, Christoph Röllig, Hubert Serve, Thomas Oellerich, Tim Sauer, Caroline Pabst, Xiaobing Yu, Haiyang Yun, Michelle Lotze, Stefanie Göllner, Daria Fijalkowska, Anna-Katharina Wirth, Jingdong Cheng, Christian Rohde, Yi Liu, Nesrine Aroua, Fengbiao Zhou
The development and regulation of malignant self-renewal remain unresolved issues. Here, we provide biochemical, genetic, and functional evidence that dynamics in ribosomal RNA (rRNA) 2′-O-methylation regulate leukemia stem cell (LSC) activity in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20d5140ae18a30f1151c71a2b4b87b2
https://doi.org/10.1158/2159-8290.c.6549778
https://doi.org/10.1158/2159-8290.c.6549778
Autor:
Carsten Müller-Tidow, Andreas Trumpp, Roland Beckmann, Irmela Jeremias, Jeroen Krijgsveld, Simon Raffel, Michaela Frye, Claudia Baldus, Christian Thiede, Martin Bornhäuser, Christoph Röllig, Hubert Serve, Thomas Oellerich, Tim Sauer, Caroline Pabst, Xiaobing Yu, Haiyang Yun, Michelle Lotze, Stefanie Göllner, Daria Fijalkowska, Anna-Katharina Wirth, Jingdong Cheng, Christian Rohde, Yi Liu, Nesrine Aroua, Fengbiao Zhou
Supplementary table S1 shows all rRNA 2’-O-methylation sites identified in human AMLs. Supplementary table S2 shows dynamic rRNA 2’-O-methylation sites in each DyMeC cluster. Supplementary table S3 shows the location of rRNA 2’-O-methylation st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1c7a9fb26a8e9e9d4765de9d996d9d
https://doi.org/10.1158/2159-8290.22541983
https://doi.org/10.1158/2159-8290.22541983
Autor:
Anna-Katharina Wirth, Lucas Wange, Sebastian Vosberg, Kai-Oliver Henrich, Christian Rausch, Erbey Özdemir, Christina M. Zeller, Daniel Richter, Tobias Feuchtinger, Markus Kaller, Heiko Hermeking, Philipp A. Greif, Daniela Senft, Vindi Jurinovic, Ehsan Bahrami, Ashok Kumar Jayavelu, Frank Westermann, Matthias Mann, Wolfgang Enard, Tobias Herold, Irmela Jeremias
Publikováno v:
Leukemia 36, 2863–2874 (2022)
Resistance towards cancer treatment represents a major clinical obstacle, preventing cure of cancer patients. To gain mechanistic insights, we developed a model for acquired resistance to chemotherapy by treating mice carrying patient derived xenogra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f9395b1322a9ef69aa26f639d8b0ff
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66607
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66607
Autor:
Wolfgang Hammerschmidt, Wen-Hsin Liu, Paulina Mrozek-Gorska, Tobias Herold, Michela Carlet, Irmela Jeremias, Kerstin Völse, Dagmar Pich, Larissa Schwarzkopf, Anna-Katharina Wirth, M. Camila Melo-Narváez
Publikováno v:
Biomarker Research, Vol 8, Iss 1, Pp 1-15 (2020)
Biomarker Research
Biomark. Res. 8:46 (2020)
Biomarker Research
Biomark. Res. 8:46 (2020)
Background Clinically relevant methods are not available that prioritize and validate potential therapeutic targets for individual tumors, from the vast amount of tumor descriptive expression data. Methods We established inducible transgene expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08532e8cd2234f2739cfc3d50759b73d
https://doi.org/10.1186/s40364-020-00226-z
https://doi.org/10.1186/s40364-020-00226-z
Autor:
Tobias Herold, Matthias Mann, Martin Becker, Irmela Jeremias, Rupert Öllinger, Anna-Katharina Wirth, Ehsan Bahrami, Binje Vick, Ashok Kumar Jayavelu, Roland Rad, Jan Philipp Schmid
Publikováno v:
Blood. 138:708-708
Acute leukemias require more accurate and effective treatments, especially upon disease relapse. In search for novel therapeutic targets for acute leukemias, we established a pipeline for CRISPR-Cas9 mediated functional genomic screens which harbor t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14d2e662c77175dadc75800e7e5f42ab
https://doi.org/10.1182/blood-2021-149658
https://doi.org/10.1182/blood-2021-149658
Inducible transgene expression in PDX models in vivo identifies KLF4 as therapeutic target for B-ALL
Autor:
Wen-Hsin Liu, Tobias Herold, Paulina Mrozek-Gorska, Dagmar Pich, Kerstin Völse, Irmela Jeremias, M. Camila Melo-Narváez, Larissa Schwarzkopf, Wolfgang Hammerschmidt, Michela Carlet, Anna-Katharina Wirth
Clinic-close methods are not available that prioritize and validate potential therapeutic targets in individual tumors from the vast bulk of descriptive expression data. We developed a novel technique to express transgenes in established patient-deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c31eb6500d24a98703da77bf954419f
Autor:
Wen-Hsin Liu, Paulina Mrozek-Gorska, Tobias Herold, Larissa Schwarzkopf, Dagmar Pich, Kerstin Völse, Anna-Katharina Wirth, M. Camila Melo-Narváez, Michela Carlet, Wolfgang Hammerschmidt, Irmela Jeremias
Publikováno v:
biorxiv.org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::6c31eb6500d24a98703da77bf954419f