Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Anna-Kaisa Rimpelä"'
Autor:
Anna-Kaisa Rimpelä, Michel Garneau, Katja S. Baum-Kroker, Tanja Schönberger, Frank Runge, Achim Sauer
Publikováno v:
Pharmaceutics, Vol 12, Iss 12, p 1174 (2020)
The rat is a commonly used species in ocular drug research. Detailed methods of separating rat ocular tissues have not been described in literature. To understand the intraocular drug distribution, we developed a robust method for the separation of i
Externí odkaz:
https://doaj.org/article/40c26c3a9cb9433e9e1f974a09ebe070
Autor:
Laura Hellinen, Sina Bahrpeyma, Anna-Kaisa Rimpelä, Marja Hagström, Mika Reinisalo, Arto Urtti
Publikováno v:
Pharmaceutics, Vol 12, Iss 6, p 554 (2020)
Interactions between drugs and melanin pigment may have major impacts on pharmacokinetics. Therefore, melanin binding can modify the efficacy and toxicity of medications in ophthalmic and other disease of pigmented tissues, such as melanoma. As melan
Externí odkaz:
https://doaj.org/article/5aa019cdeee841dabc45578783f50f16
Publikováno v:
Pharmaceutics, Vol 11, Iss 1, p 9 (2018)
Biologicals are important ocular drugs that are be delivered using monthly and bimonthly intravitreal injections to treat retinal diseases, such as age-related macular degeneration. Long acting delivery systems are needed for prolongation of their do
Externí odkaz:
https://doaj.org/article/4f074820a58f4213bac5319345e7ee7c
Autor:
Frank Runge, Anna-Kaisa Rimpelä, Achim Sauer, Michel Garneau, Katja S. Baum-Kroker, Tanja Schönberger
Publikováno v:
Pharmaceutics, Vol 12, Iss 1174, p 1174 (2020)
Pharmaceutics
Volume 12
Issue 12
Pharmaceutics
Volume 12
Issue 12
The rat is a commonly used species in ocular drug research. Detailed methods of separating rat ocular tissues have not been described in literature. To understand the intraocular drug distribution, we developed a robust method for the separation of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189cf5a57435bba3da57ff786d1a0aa0
https://www.mdpi.com/1999-4923/12/12/1174
https://www.mdpi.com/1999-4923/12/12/1174
Autor:
Carina M, Weigelt, Nina, Zippel, Holger, Fuchs, Anna-Kaisa, Rimpelä, Tanja, Schönberger, Birgit, Stierstorfer, Remko A, Bakker, Norbert H, Redemann
Publikováno v:
Translational Vision Science & Technology. 11:18
Inflammation is implicated in the etiology of diverse retinopathies including uveitis, age-related macular degeneration or diabetic retinopathy. Tumor necrosis factor alpha (TNF-α) is a well-known proinflammatory cytokine that is described as a biom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae86f7b4c4aa56d4d7de25ab7061ed9
https://doi.org/10.1167/tvst.11.5.18
https://doi.org/10.1167/tvst.11.5.18
Publikováno v:
Acta Ophthalmologica. 97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ffa0133270a5edd2b3d171aae772618
https://doi.org/10.1111/j.1755-3768.2019.5366
https://doi.org/10.1111/j.1755-3768.2019.5366
Publikováno v:
Molecular Pharmaceutics. 15:2174-2179
Pharmacokinetics in the posterior eye segment has therapeutic implications due to the importance of retinal diseases in ophthalmology. In principle, drug binding to the components of the vitreous, such as proteins, collagen, or glycosaminoglycans, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413ec1f9debc0a7f48eec2cc1365037a
https://doi.org/10.1021/acs.molpharmaceut.8b00038
https://doi.org/10.1021/acs.molpharmaceut.8b00038
Autor:
Mika Reinisalo, Eva M. del Amo, Anna-Kaisa Rimpelä, Heidi Kidron, Laura Hellinen, Evgeni Grazhdankin, Arto Urtti
Publikováno v:
Advanced Drug Delivery Reviews. 126:23-43
Pigmented ocular tissues contain melanin within the intracellular melanosomes. Drugs bind to melanin at varying extent that ranges from no binding to extensive binding. Binding may lead to drug accumulation to the pigmented tissues and prolonged drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9335008a14443a9b676385c1e17e0ee
https://doi.org/10.1016/j.addr.2017.12.008
https://doi.org/10.1016/j.addr.2017.12.008
Publikováno v:
Pharmaceutics
Volume 11
Issue 1
Pharmaceutics, Vol 11, Iss 1, p 9 (2018)
Volume 11
Issue 1
Pharmaceutics, Vol 11, Iss 1, p 9 (2018)
Biologicals are important ocular drugs that are be delivered using monthly and bimonthly intravitreal injections to treat retinal diseases, such as age-related macular degeneration. Long acting delivery systems are needed for prolongation of their do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfd01c5350fd97a1abf68629285ac55
Publikováno v:
Molecular Pharmaceutics. 13:1251-1257
Melanin has a high binding affinity for a wide range of drugs. The determination of the melanin binding capacity and its binding affinity are important, e.g., in the determination of the ocular drug distribution, the prediction of drug effects in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4c27e97758c0340fac3b3ea2aa5709
https://doi.org/10.1021/acs.molpharmaceut.5b00783
https://doi.org/10.1021/acs.molpharmaceut.5b00783