Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions

Autor: João D. Pereira, Daniel M. DuBreuil, Anna-Claire Devlin, Aaron Held, Yechiam Sapir, Eugene Berezovski, James Hawrot, Katherine Dorfman, Vignesh Chander, Brian J. Wainger

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Organoids have improved disease modeling. Here, the authors generate human sensorimotor organoids derived from hiPSCs of individuals with ALS. These organoids contain skeletal muscle, sensory and motor neurons as well as astrocytes, microglia, and va

Externí odkaz: https://doaj.org/article/9db38ffd5c8547aa9bc606ed08d490ee

Non-typeable Haemophilus influenzae chronic colonization in chronic obstructive pulmonary disease (COPD)

Autor: Gordon Ramage, Lorcan McGarvey, Stephen A Carson, Bryn Short, Anna-Claire Devlin, Keith D. Thornbury, Fionnuala Lundy, James Reihill, Craig Williams, William G. Mackay, S. Lorraine Martin, Anne Crilly

Publikováno v: Short, B, Carson, S, Devlin, A-C, Reihill, J A, Crilly, A, MacKay, W, Ramage, G, Williams, C, Lundy, F T, McGarvey, L P, Thornbury, K D & Martin, L 2021, ' Non-typeable Haemophilus influenzae chronic colonization in chronic obstructive pulmonary disease (COPD) ', Critical Reviews in Microbiology, vol. 47, no. 2, pp. 192-205 . https://doi.org/10.1080/1040841X.2020.1863330

Haemophilus influenzae is the most common cause of bacterial infection in the lungs of chronic obstructive pulmonary disease (COPD) patients and contributes to episodes of acute exacerbation which are associated with increased hospitalization and mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f119a7a145cf6dd72ffc805044bd6f02
https://doi.org/10.1080/1040841x.2020.1863330

A Cultured Sensorimotor Organoid Model Forms Human Neuromuscular Junctions

Autor: Yechiam Sapir, Anna-Claire Devlin, Vignesh Chander, Katherine Dorfman, Eugene Berezovski, João D. Pereira, James Hawrot, Brian J. Wainger, Daniel M. DuBreuil, Aaron Held

Human induced pluripotent stem cells (iPSCs) hold promise for modeling diseases in individual human genetic backgrounds and thus for developing precision medicine. Here, we generate sensorimotor organoids containing physiologically functional neuromu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4b69b47c6b20003451f64653b073b83
https://doi.org/10.1101/2021.03.03.433128

Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology

Autor: Maria Stavrou, Bhuvaneish T. Selvaraj, Veronica Brivio, Anna-Claire Devlin, Arpan R Mehta, Xin He, Gareth B. Miles, Owen Dando, Christopher Shaw, Karen Burr, Chen Zhao, Siddharthan Chandran, Giles E. Hardingham, Amit K. Chouhan, David Story

Publikováno v: Glia
Zhao, C, Devlin, A, Chouhan, A K, Selvaraj, B T, Stavrou, M, Burr, K, Brivio, V, He, X, Mehta, A R, Story, D, Shaw, C E, Dando, O, Hardingham, G E, Miles, G B & Chandran, S 2019, ' Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology ', Glia . https://doi.org/10.1002/glia.23761

Mutations in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS). Accumulating evidence implicates astrocytes as important non‐cell autonomous contributors to ALS pathogenesis, although the potential deleterious effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977502e67fb4b0ed4391d7d372609310
https://lirias.kuleuven.be/handle/123456789/653663

Sensorimotor Organoids for Neuromuscular Disease

Autor: Anna-Claire Devlin, Eugene Berezovski, João D. Pereira, Daniel M. DuBreuil, Yechiam Sapir, Brian J. Wainger, Vignesh Chander

Publikováno v: SSRN Electronic Journal.

Human induced pluripotent stem cells (iPSCs) hold substantial promise for modeling diseases in the relevant human genetic backgrounds. Here, we leverage the shared developmental pathways of spinal neuroectoderm and paraxial mesoderm via neuromesoderm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e97d67aaa69cf5f544f23b71eabb3b2c
https://doi.org/10.2139/ssrn.3335779