Potent Biological Activity of Fluorinated Derivatives of 2-Deoxy-d-Glucose in a Glioblastoma Model

Autor: Maja Sołtyka-Krajewska, Marcin Ziemniak, Anna Zawadzka-Kazimierczuk, Paulina Skrzypczyk, Ewelina Siwiak-Niedbalska, Anna Jaśkiewicz, Rafał Zieliński, Izabela Fokt, Stanisław Skóra, Wiktor Koźmiński, Krzysztof Woźniak, Waldemar Priebe, Beata Pająk-Tarnacka

Publikováno v: Biomedicines, Vol 12, Iss 10, p 2240 (2024)

Background: One defining feature of various aggressive cancers, including glioblastoma multiforme (GBM), is glycolysis upregulation, making its inhibition a promising therapeutic approach. One promising compound is 2-deoxy-d-glucose (2-DG), a d-gluco

Externí odkaz: https://doaj.org/article/6d606b7bd79e4c7ba8de139e5102bb5f

Experimental and Computational Studies on Structure and Energetic Properties of Halogen Derivatives of 2-Deoxy-D-Glucose

Autor: Marcin Ziemniak, Anna Zawadzka-Kazimierczuk, Sylwia Pawlędzio, Maura Malinska, Maja Sołtyka, Damian Trzybiński, Wiktor Koźmiński, Stanisław Skora, Rafał Zieliński, Izabela Fokt, Waldemar Priebe, Krzysztof Woźniak, Beata Pająk

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 7, p 3720 (2021)

The results of structural studies on a series of halogen-substituted derivatives of 2-deoxy-D-glucose (2-DG) are reported. 2-DG is an inhibitor of glycolysis, a metabolic pathway crucial for cancer cell proliferation and viral replication in host cel

Externí odkaz: https://doaj.org/article/09ad06b085f54d19b44d9672b7f46f45

Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin

Autor: Ariadna Rodriguez Chamorro, Andrea Ghisleni, Pierantonio Doto, Eneda Hollerl, Borja Mateos, Wiktor Kozminski, Robert Konrat, Kristina Djinović-Carugo, Miriam Pedron, Dmitri I. Svergun, Friedel Drepper, Anna Zawadzka-Kazimierczuk, Julius Kostan, Bettina Warscheid, Bojan Zagrovic, Georgine Faulkner, Claudia Schreiner, Joan L. Arolas, G. Mlynek, Euripedes de Almeida Ribeiro, Thomas Peterbauer, Cy M. Jeffries, Antonio Sponga, Leonhard Geist, Anton A. Polyansky, Mathias Gautel, Thomas C. Schwarz

Publikováno v: Science Advances
Science advances 7(22), eabg7653-(2021). doi:10.1126/sciadv.abg7653
'Science Advances ', vol: 7, pages: eabg7653-1-eabg7653-20 (2021)

Science advances 7(22), eabg7653 - (2021). doi:10.1126/sciadv.abg7653
In sarcomeres, α-actinin cross-links actin filaments and anchors them to the Z-disk. FATZ (filamin-, α-actinin-, and telethonin-binding protein of the Z-disk) proteins inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6df15fcff097138a51c1137346fd138
http://europepmc.org/articles/PMC8163081

Using Cross‐Correlated Spin Relaxation to Characterize Backbone Dihedral Angle Distributions of Flexible Protein Segments

Autor: Georg Kontaxis, Clemens Kauffmann, Anna Zawadzka-Kazimierczuk, Robert Konrat

Publikováno v: Chemphyschem

Crucial to the function of proteins is their existence as conformational ensembles sampling numerous and structurally diverse substates. Despite this widely accepted notion there is still a high demand for meaningful and reliable approaches to charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48aad987bb63ae5224da986c487b24a5
https://doi.org/10.1002/cphc.202000789

High-dimensional NMR methods for intrinsically disordered proteins studies

Autor: Wiktor Koźmiński, Katarzyna Grudziąż, Anna Zawadzka-Kazimierczuk

Publikováno v: Methods. 148:81-87

Intrinsically disordered proteins (IDPs) are getting more and more interest of the scientific community. Nuclear magnetic resonance (NMR) is often a technique of choice for these studies, as it provides atomic-resolution information on structure, dyn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83c91ea7aca450c3642eace7040e0a8
https://doi.org/10.1016/j.ymeth.2018.04.031