Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Anna Winqvist"'
Autor:
Xiao-Xiong Zhou, Mark D. Smith, Hans Maag, David Bernard Smith, Isabel Najera, Genadiy Kalayanov, Sophie Le Pogam, Tatiana Maltseva, Vincent Leveque, Ann C. Kaiser, Kurt Benkestock, Anna Winqvist, Nils Gunnar Johansson, Steven Swallow, Sonal Rajyaguru, Joseph A. Martin, Christian Sund, Nick Cammack, Klaus Klumpp
Publikováno v:
Journal of Medicinal Chemistry. 52:2971-2978
The discovery of 4'-azidocytidine (3) (R1479) (J. Biol. Chem. 2006, 281, 3793; Bioorg. Med. Chem. Lett. 2007, 17, 2570) as a potent inhibitor of RNA synthesis by NS5B (EC(50) = 1.28 microM), the RNA polymerase encoded by hepatitis C virus (HCV), has
Autor:
Roger Strömberg, Anna Winqvist
Publikováno v:
European Journal of Organic Chemistry. 2008:1705-1714
Condensation of a uridine 3′-deoxy-3′-C-methylenephosphinate with thymidine and guanosine derivatives to form methylenephosphinate esters was investigated. A number of different condensing agents were compared, and these include pivaloyl chloride
Publikováno v:
Chem. Commun.. 49:9036-9038
A 3'-deoxy-3'-C-methylenephosphonate modified diribonucleotide is highly resistant to degradation by spleen phosphodiesterase and not cleaved at all by snake venom phosphodiesterase. The most remarkable finding is that, despite the fact that both the
Autor:
Roger Strömberg, Anna Winqvist
Publikováno v:
European Journal of Organic Chemistry. 2002:3140-3144
A study on the iodine oxidation of protected thymidine 5′-(uridine 3′-deoxy-3′-C-methylenephosphinate) (1) to the corresponding thymidine 5′-(uridine 3′-deoxy-3′-C-methylenephosphonate) (2) is reported. Oxidation with 80 mM iodine in pyri
Autor:
Anna Winqvist, Roger Strömberg
Publikováno v:
European Journal of Organic Chemistry. 2002:1509-1515
An efficient method for the synthesis of nucleoside 3′-C-methylenephosphinates, building blocks for oligo(ribonucleoside methylenephosphonate)s, has been developed. Treatment of bis(trimethylsilyl)hypophosphite (BTSP) with a 3′-deoxy-3-C-(iodomet
Autor:
Kenneth Alan Simmen, Tatiana Agback, Michael Pelcman, Herman de Kock, Horst Wähling, Christina Rydegård, Joseph A. Martin, Magnus Nilsson, Pierre Raboisson, Pedro Pinho, Xiao Xiong Zhou, Anna Winqvist, Kurt Benckestock, David Bernard Smith, Mirva Boothee, Christian Sund, Bertil Samuelsson, Lotta Vrang, Åsa Rosenquist, Nils Gunnar Johansson, Anna Karin Gertrud Linnea Belfrage, Sophie Lachau-Durand, Klaus Klumpp, Koen Vandyck, Kristina Wikström, Ylva Terelius, Tim H. M. Jonckers, Tse-I Lin, Genadiy Kalayanov, Anneli Lindqvist
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(9)
4′-Azido-2′-deoxy-2′-methylcytidine ( 14 ) is a potent nucleoside inhibitor of the HCV NS5B RNA-dependent RNA polymerase, displaying an EC 50 value of 1.2 μM and showing moderate in vivo bioavailability in rat ( F = 14%). Here we describe the
Autor:
R. Stroemberg, Anna Winqvist
Publikováno v:
ChemInform. 32
Autor:
Anna Winqvist, R. Stroemberg
Publikováno v:
ChemInform. 33
Autor:
Veronique Morisson, Xiao-Xiong Zhou, Vincent Leveque, Isabel Najera, Sophie Le Pogam, Mark D. Smith, Genadiy Kalayanov, Hans Maag, Tatiana Maltseva, David Bernard Smith, Joseph A. Martin, Kurt Benkestock, Pedro Pinho, Anna Winqvist, Nick Cammack, Nils Gunnar Johansson, Christian Sund, Steven Swallow, Klaus Klumpp, Sonal Rajyaguru
Publikováno v:
Journal of medicinal chemistry. 52(1)
4'-Azidocytidine 3 (R1479) has been previously discovered as a potent and selective inhibitor of HCV replication targeting the RNA-dependent RNA polymerase of hepatitis C virus, NS5B. Here we describe the synthesis and biological evaluation of severa
Autor:
Roger Strömberg, Anna Winqvist
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 20(4-7)
A novel method for preparation of 1-[2-O-(tert-butyldimethylsilyl)-3- deoxy-3-C-hydroxymethyl-5-O-monomethoxytrityl-beta-D-ribo- pentofuranosyl]uracil by hydroboration of corresponding 3'-deoxy-3'-C-methyleneuridine derivative has been developed. Fur