Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Anna Wilbrey"'
Autor:
Matthew D. Young, Thomas J. Mitchell, Lars Custers, Thanasis Margaritis, Francisco Morales-Rodriguez, Kwasi Kwakwa, Eleonora Khabirova, Gerda Kildisiute, Thomas R. W. Oliver, Ronald R. de Krijger, Marry M. van den Heuvel-Eibrink, Federico Comitani, Alice Piapi, Eva Bugallo-Blanco, Christine Thevanesan, Christina Burke, Elena Prigmore, Kirsty Ambridge, Kenny Roberts, Felipe A. Vieira Braga, Tim H. H. Coorens, Ignacio Del Valle, Anna Wilbrey-Clark, Lira Mamanova, Grant D. Stewart, Vincent J. Gnanapragasam, Dyanne Rampling, Neil Sebire, Nicholas Coleman, Liz Hook, Anne Warren, Muzlifah Haniffa, Marcel Kool, Stefan M. Pfister, John C. Achermann, Xiaoling He, Roger A. Barker, Adam Shlien, Omer A. Bayraktar, Sarah A. Teichmann, Frank C. Holstege, Kerstin B. Meyer, Jarno Drost, Karin Straathof, Sam Behjati
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dediff
Externí odkaz:
https://doaj.org/article/07a679f9a06e4d84ac2da9b571bfc2a4
Autor:
Aristos J Alexandrou, Adam R Brown, Mark L Chapman, Mark Estacion, Jamie Turner, Malgorzata A Mis, Anna Wilbrey, Elizabeth C Payne, Alex Gutteridge, Peter J Cox, Rachel Doyle, David Printzenhoff, Zhixin Lin, Brian E Marron, Christopher West, Nigel A Swain, R Ian Storer, Paul A Stupple, Neil A Castle, James A Hounshell, Mirko Rivara, Andrew Randall, Sulayman D Dib-Hajj, Douglas Krafte, Stephen G Waxman, Manoj K Patel, Richard P Butt, Edward B Stevens
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152405 (2016)
Human genetic studies show that the voltage gated sodium channel 1.7 (Nav1.7) is a key molecular determinant of pain sensation. However, defining the Nav1.7 contribution to nociceptive signalling has been hampered by a lack of selective inhibitors. H
Externí odkaz:
https://doaj.org/article/b9af198893454af186b55747950a6251
Autor:
Rik G.H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, Masahiro Yoshida, David Scobie, Helen R. Wagstaffe, Laura Richardson, Anna Wilbrey-Clark, Josephine L. Barnes, Krzysztof Polanski, Jessica Allen-Hyttinen, Puja Mehta, Dinithi Sumanaweera, Jacqueline Boccacino, Waradon Sungnak, Ni Huang, Lira Mamanova, Rakesh Kapuge, Liam Bolt, Elena Prigmore, Ben Killingley, Mariya Kalinova, Maria Mayer, Alison Boyers, Alex Mann, Vitor Teixeira, Sam M. Janes, Rachel C. Chambers, Muzlifah Haniffa, Andrew Catchpole, Robert Heyderman, Mahdad Noursadeghi, Benny Chain, Andreas Mayer, Kerstin B. Meyer, Christopher Chiu, Marko Z. Nikolić, Sarah A. Teichmann
The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the cellular disease dynamics remains limited. In our unique COVID-19 human challenge study we used single cell genomics of nasopharyngeal swabs and blood to temporall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d220950228bcc70a9b7e6d3734f32b9f
https://doi.org/10.1101/2023.04.13.23288227
https://doi.org/10.1101/2023.04.13.23288227
Autor:
Kazumasa Kanemaru, James Cranley, Daniele Muraro, Antonio M.A. Miranda, Jan Patrick Pett, Monika Litvinukova, Natsuhiko Kumasaka, Siew Yen Ho, Krzysztof Polanski, Laura Richardson, Lukas Mach, Monika Dabrowska, Nathan Richoz, Sam N. Barnett, Shani Perera, Anna Wilbrey-Clark, Carlos Talavera-López, Ilaria Mulas, Krishnaa T. Mahbubani, Liam Bolt, Lira Mamanova, Liz Tuck, Lu Wang, Margaret M. Huang, Martin Prete, Sophie Pritchard, John Dark, Kourosh Saeb-Parsy, Minal Patel, Menna R. Clatworthy, Norbert Hübner, Rasheda A. Chowdhury, Michela Noseda, Sarah A. Teichmann
A cell’s function is defined by its intrinsic characteristics and its niche: the tissue microenvironment in which it dwells. Here, we combine single-cell and spatial transcriptomic data to discover cellular niches within eight regions of the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f76444d5783c68c780deca00434aee0
https://doi.org/10.1101/2023.01.30.526202
https://doi.org/10.1101/2023.01.30.526202
Autor:
Josephine L. Barnes, Peng He, Masahiro Yoshida, Kaylee B. Worlock, Rik G.H. Lindeboom, Chenqu Suo, J. Patrick Pett, Anna Wilbrey-Clark, Emma Dann, Lira Mamanova, Laura Richardson, Amanda J. Oliver, Adam Pennycuick, Jessica Allen-Hyttinen, Iván T. Herczeg, Robert E. Hynds, Vitor H. Teixeira, Muzlifah Haniffa, Kyungtae Lim, Dawei Sun, Emma L. Rawlins, Krzysztof Polanski, Paul A. Lyons, John C. Marioni, Zewen Kelvin Tuong, Menna R. Clatworthy, James L. Reading, Sam M. Janes, Sarah A. Teichmann, Kerstin B. Meyer, Marko Z. Nikolić
During human development, lungs develop their roles of gas exchange and barrier function. Recent single cell studies have focused on epithelial and mesenchymal cell types, but much less is known about the developing lung immune cells, although the ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba9e470f99f21542bfed3c556bfdae9f
https://doi.org/10.1101/2022.12.13.519713
https://doi.org/10.1101/2022.12.13.519713
Autor:
Kerstin Meyer, Elo Madissoon, Amanda Oliver, Vitalii Kleshchevnikov, Anna Wilbrey-Clark, Krzysztof Polański, Nathan Richoz, Ana Elisa Ribeiro Orsi, Lira Mamanova, Liam Bolt, Rasa Elmentaite, Jan Pett, Ni Huang, Chuan Xu, Peng He, Monika Dabrowska, Sophie Pritchard, Elizabeth Tuck, Elena Prigmore, Shani Perera, Andrew Knights, Agnes Oszlanczi, Adam Hunter, Sara Filipa Vieira, Minal Patel, Masahiro Yoshida, Kaylee Worlock, Rik Lindeboom, Marko Nikolic, Nikitas Georgakopoulos, Krishna Mahbubani, Kourosh Saeb-Parsy, Omer Ali Bayraktar, Menna Clatworthy, Oliver Stegle, Natsuhiko Kumasaka, Sarah Teichmann
To (re)define tissue architecture of the lung and airways at the cellular and molecular level, we profiled five proximal-to-distal locations of healthy human lungs in depth using multi-omic single cell/nuclei and Visium Spatial Transcriptomics. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adc360382d632f87b2aa4fbae3cabbbc
https://doi.org/10.21203/rs.3.rs-1650134/v1
https://doi.org/10.21203/rs.3.rs-1650134/v1
Autor:
Malte Luecken, Lisa Sikkema, Daniel Strobl, Luke Zappia, Elo Madissoon, Nikolay Markov, Laure-Emmanuelle Zaragosi, Meshal Ansari, Marie-Jeanne Arguel, Leonie Apperloo, Christophe Becavin, Marijn Berg, Evgeny Chichelnitskiy, Mei-i Chung, Antoine Collin, Aurore Gay, Baharak Hooshiar Kashani, Manu Jain, Theodore Kapellos, Tessa Kole, Christoph Mayr, Michael von Papen, Lance Peter, Ciro Ramírez-Suástegui, Janine Schniering, Chase Taylor, Thomas Walzthoeni, Chuan Xu, Linh Bui, Carlo de Donno, Leander Dony, Minzhe Guo, Austin Gutierrez, Lukas Heumos, Ni Huang, Ignacio Ibarra Del Río, Nathan Jackson, Preetish Kadur Lakshminarasimha Murthy, Mohammad Lotfollahi, Tracy Tabib, Carlos Talavera-Lopez, Kyle Travaglini, Anna Wilbrey-Clark, Kaylee Worlock, Masahiro Yoshida, Tushar Desai, Orit Rozenblatt-Rosen, Christine Falk, Naftali Kaminski, Mark Krasnow, Robert Lafyatis, Marko Nikolic, Joseph Powell, Jay Rajagopal, Max Seibold, Dean Sheppard, Douglas Shepherd, Sarah Teichmann, Alexander Tsankov, Jeffrey Whitsett, Yan Xu, Nicholas Banovich, Pascal Barbry, Thu Duong, Kerstin Meyer, Jonathan Kropski, Dana Pe'er, Herbert Schiller, Purushothama Rao Tata, Joachim Schultze, Maarten van den Berge, Yuexin Chen, James Hagood, Ahmed Hassan, Peter Horvath, Joakim Lundeberg, Sylvie Leroy, Charles Marquette, Gloria Pryhuber, Christos Samakovlis, Xin Sun, Lorraine Ware, Kun Zhang, Alexander Misharin, Martijn Nawijn, Fabian Theis
Organ- and body-scale cell atlases have the potential to transform our understanding of human biology. To capture the variability present in the population, these atlases must include diverse demographics such as age and ethnicity from both healthy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c225b8ec842494e3c796c31c793715c
https://doi.org/10.21203/rs.3.rs-1438584/v1
https://doi.org/10.21203/rs.3.rs-1438584/v1
Autor:
Amanda Oliver, Elo Madissoon, Vitalii Kleshchevnikov, Anna Wilbrey-Clark, Kryzysztof Polanski, Ana Elisa Ribeiro Orsi, Lira Mamanova, Liam Bolt, J. Patrick Pett, Ni Huang, Rasa Elmentaite, Nathan Richoz, Peng He, Monika Dabrowska, Liz Tuck, Elena Prigmore, Andrew Knights, Agnes Oszlanczi, Adam Hunter, Sophie Pritchard, Sara Filipa Vieira, Minal Patel, Krishnaa Mahbubani, Nikitas Georgakapopoulos, Menna Clatworthy, Oliver Stegle, Kourosh Saeb-Parsy, Natsuhiko Kumasaka, Sarah Teichmann, Kerstin Meyer
Publikováno v:
Airway cell biology and immunopathology.
Autor:
Anna Wilbrey-Clark, Vitalii Kleshchevnikov, Nathan Richoz, Ana Ribeiro Orsi, Liam Bolt, Lira Mamanova, Sophie Pritchard, Rasa Elmentaite, Natsuhiko Kumasaka, Minal Patel, Kourosh Saeb-Parsy, Sara F. Vieira, Adam Hunter, Menna R. Clatworthy, Elo Madissoon, Peng He, Monika Dabrowska, Agnes Oszlanczi, Elena Prigmore, Andrew J Knights, Oliver Stegle, Liz Tuck, Ni Huang, Nikitas Georgakopoulos, Omer Ali Bayraktar, Krzysztof Polanski, Kerstin B. Meyer, Krishnaa T. Mahbubani, J. Patrick Pett, Sarah A. Teichmann, Amanda Oliver
SummaryMultiple distinct cell types of the human lung and airways have been defined by single cell RNA sequencing (scRNAseq). Here we present a multi-omics spatial lung atlas to define novel cell types which we map back into the macro- and micro-anat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b89f02ae2bc2e1b29bc78b842ac3fc65
https://doi.org/10.1101/2021.11.26.470108
https://doi.org/10.1101/2021.11.26.470108
Autor:
Rgh Lindeboom, BC Jones, Muzlifah Haniffa, Laura Richardson, C Dominguez Conde, JP Pett, Sean B. Smith, Elo Madissoon, V Chu, Ca Gao, Aarash Saleh, Sarah Teichmann, Krzysztof Polanski, Eliz Kilich, A-K Reuschl, Jessica Allen-Hyttinen, Neil J. Sebire, Kerstin B. Meyer, H Yung, Alexander V. Misharin, A Saigal, Clatworthy, Clare Jolly, Jane Dematte, Waradon Sungnak, C Cane, Marko Nikolic, Colin R. Butler, Ni Huang, Puja Mehta, Claire Smith, Elena Prigmore, Natsuhiko Kumasaka, Fernando J Calero-Nieto, Taylor A. Poor, Josephine Barnes, S Shibuya, NU Script Study Investigators, Kaylee B Worlock, AC Argento, Anna Wilbrey-Clark, A Iordanidou, Sam M. Janes, P De Coppi, Matthew L Coates, Jonathan M. Cohen, Liam Bolt, Lira Mamanova, Masahiro Yoshida, Berthold Göttgens, Gary Reynolds, Richard G. Wunderink, Christopher O'Callaghan, Georgina Bowyer, A de Wilton
Publikováno v:
BTS/BALR/AUK-BLF Early Career Investigator Symposium.
T1 Figure 1ConclusionsOverall, this largest paediatric single cell COVID-19 study to date showed significant differences in response to SARS-CoV-2 between children and adults, reflecting the changes of the immune landscape over developmental time, wh