Secukinumab in non-radiographic axial spondyloarthritis: subgroup analysis based on key baseline characteristics from a randomized phase III study, PREVENT

Autor: Ricardo Blanco, Sibylle Haemmerle, Atul Deodhar, Hideto Kameda, Stephen Hall, Marleen G H van de Sande, Helena Marzo-Ortega, Jürgen Braun, Denis Poddubnyy, Abhijit Shete, Anna Wiksten, Brian Porter, Hanno B. Richards, Lianne S. Gensler, Filip Van den Bosch

Publikováno v: Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-10 (2021)
Arthritis research & therapy, 23(1):231. BioMed Central
ARTHRITIS RESEARCH & THERAPY

Background To investigate the efficacy of secukinumab in patients with active non-radiographic axial spondyloarthritis (nr-axSpA) grouped by disease activity as assessed by C-reactive protein (CRP) levels and/or magnetic resonance imaging (MRI) score

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb5b1cc3bcb07a8d820e9d30c284473
http://europepmc.org/articles/PMC8418044

Nonproportional Hazards in Network Meta-Analysis: Efficient Strategies for Model Building and Analysis

Autor: Neil Hawkins, Hans-Peter Piepho, Anna Wiksten, Sandro Gsteiger

Publikováno v: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 23(7)

Objectives To develop efficient approaches for fitting network meta-analysis (NMA) models with time-varying hazard ratios (such as fractional polynomials and piecewise constant models) to allow practitioners to investigate a broad range of models rap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496c7ea1442c89050eb11326800290a7
https://pubmed.ncbi.nlm.nih.gov/32762994

Estimating Relative Efficacy in Acute Postoperative Pain:Network Meta-Analysis is Consistent with Indirect Comparison to Placebo Alone

Autor: Dominic Aldington, Philip J Wiffen, Sheena Derry, Christopher Eccleston, R Andrew Moore, Anna Wiksten, Ekkehard Glimm, Rajesh Karan, Samik Banerjee

Publikováno v: Moore, R A, Derry, S, Wiffen, P J, Banerjee, S, Karan, R, Glimm, E, Wiksten, A, Aldington, D & Eccleston, C 2018, ' Estimating Relative Efficacy in Acute Postoperative Pain : Network Meta-Analysis is Consistent with Indirect Comparison to Placebo Alone ', Pain, vol. 159, no. 11, pp. 2234-2244 . https://doi.org/10.1097/j.pain.0000000000001322
Pain

Supplemental Digital Content is Available in the Text. There was no significant difference between network meta-analysis and simple placebo comparisons in postoperative pain using 261 trials, 39,753 patients, and 52 drug/dose combinations.
Netwo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3710c197c816c267e41967a3437b16
https://purehost.bath.ac.uk/ws/files/183719805/PAIN_D_18_00299_R1.pdf

Hartung-Knapp method is not always conservative compared with fixed-effect meta-analysis

Autor: Anna, Wiksten, Gerta, Rücker, Guido, Schwarzer

Publikováno v: Statistics in medicine. 35(15)

A widely used method in classic random-effects meta-analysis is the DerSimonian-Laird method. An alternative meta-analytical approach is the Hartung-Knapp method. This article reports results of an empirical comparison and a simulation study of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d1d84531559a63afdf49131a0a9b01e0
https://pubmed.ncbi.nlm.nih.gov/26842654

Validity and reliability of the Finnish version of the Multiple Sclerosis Impact Scale-29

Autor: Päivi Hämäläinen, Anna Wiksten, Juhani Ruutiainen, Tanja Hakkarainen, Eija Rosti-Otajärvi

Publikováno v: Brain and Behavior

Background The Multiple Sclerosis Impact Scale-29 (MSIS-29) has been increasingly used to evaluate the self-perceived impact of multiple sclerosis (MS) on a patient. Objectives The aim of this study was to evaluate the psychometric properties of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0f21918afe3212bf114711a0201549
https://doi.org/10.1002/brb3.725