Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Anna Waszkiewicz"'
High-Throughput Screening and Triage Assays Identify Small Molecules Targeting c-MYC in Cancer Cells
Autor:
Jon-Paul Jaworski, Lisa A. Payne, Anna Waszkiewicz, Biju Mangatt, Anthony J. Jurewicz, Lorena A. Kallal, Jesus R. Medina, Pat Brady, Xin Zeng, Thomas J. Berrodin, Carolyn Doepner-Buser, Anthony Della Pietra
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(2)
While c-MYC is well established as a proto-oncogene, its structure and function as a transcription factor have made c-MYC a difficult therapeutic target. To identify small-molecule inhibitors targeting c-MYC for anticancer therapy, we designed a high
Autor:
Joseph P. Marino, Jonathan B. Basilla, David G. Washburn, Elizabeth A. Davenport, Jeff J. McAtee, Xiaoping Xu, Dan J. Gillie, Lamont Roscoe Terrell, Irina M. Lozinskaya, Christine G. Schnackenberg, Dennis A. Holt, Anna Waszkiewicz, Michael Klein, Timothy C. Jensen, Lorena Kallal Negron, Sharada Manns, Dwight M. Morrow, Linda S. Barton, Christina Pritchard, Jeffrey Guss, Jason W. Dodson, Robert N. Willette, Rusty E. Fries
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4979-4984
Lead optimization of piperidine amide HTS hits, based on an anilino-thiazole core, led to the identification of analogs which displayed low nanomolar blocking activity at the canonical transient receptor channels 3 and 6 (TRPC3 & 6) based on FLIPR (c
Abstract 2919: Discovery of small-molecule compounds targeting c-MYC using a novel cell-based screen
Autor:
Stuart Paul Romeril, Gopinath Ganji, Dirk A. Heerding, George P. Livi, Anna Rutkowska-Klute, William Hoi Hong Li, James F. Mack, Elisabeth A. Minthorn, Derrick W. Meinhold, Carolyn A. Buser, Jesus R. Medina, Lorena A. Kallal, Shanker K. Sundaram, Biju Mangatt, Anthony Della Pietra, Sonja Ghidelli-Disse, Anna Waszkiewicz, Jon-Paul Jaworski, Thomas J. Berrodin, Rakesh Kumar, Wendy S. Halsey, Christian S. Sherk, Gerard Drewes
Publikováno v:
Cancer Research. 78:2919-2919
Elevated expression of the c-MYC oncogene (either due to gene amplification, translocation, abnormality in upstream signaling pathways and/or protein stabilization) is one of the most common abnormalities in human cancers. Efforts to identify direct
Autor:
Stefan Angielski, Anna Waszkiewicz, Magdalena Gołos, Jacek M. Witkowski, Barbara Lewko, Jan Stepinski, Elżbieta Latawiec, Anna Maryn, Agnieszka Daca
Publikováno v:
Molecular and Cellular Biochemistry
Podocytes may be direct target for glucocorticoid therapy in glomerular proteinuric disease. Permeability of podocytes largely depends on their capacity to migrate which involves the contractile apparatus in their foot processes. In this study, we ex
Autor:
James Tunstead, Robert N. Willette, Linda N. Casillas, Mui Cheung, Guosen Ye, Ming-Yuan Jian, Hasan Alsaid, John J. Lepore, Earl Gordon, John R. Toomey, Daniel S Matasic, Kristeen Maniscalco-Hauk, Chris James, J. Larkin, Kevin S. Thorneloe, Eidam Hilary Schenck, Stephen C. Lenhard, Krista B. Goodman, Lorena A. Kallal, Brian Donovan, Alan R. Olzinski, Pu Qin, Mary I. Townsley, Christine G. Schnackenberg, Lou Elefante, Weike Bao, John A. Krawiec, Theresa J. Roethke, Irina M. Lozinskaya, Kalindi Vaidya, Elizabeth A. Davenport, Melissa H. Costell, Robert W. Marquis, Beat M. Jucker, Mark E. Burgert, Anna Waszkiewicz
Publikováno v:
Science Translational Medicine. 4
Pulmonary edema resulting from high pulmonary venous pressure (PVP) is a major cause of morbidity and mortality in heart failure (HF) patients, but current treatment options demonstrate substantial limitations. Recent evidence from rodent lungs sugge