Výsledky vyhledávání - "Anna Warnecke"

Development of a Novel Imaging Agent for Determining Albumin Uptake in Solid Tumors

Autor: K Abu Ajaj, Friederike I. Nollmann, P Perez Galan, S Chercheja, J Garcia Fernandez, Magnusson Johannes Pall, Steffen Daum, Koester Stephan David, Felix Kratz, Anna Warnecke, Lara Pes, Federico Medda

Publikováno v: Nucl Med Mol Imaging

PURPOSE: The purpose of this study was to investigate the albumin-binding compound (111)In-C4-DTPA as an imaging agent for the detection of endogenous albumin accumulation in tumors. METHODS: (111)In-C4-DTPA was injected in healthy nude mice for phar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51be6a0358b100c50bd55e730c043475
https://doi.org/10.1007/s13139-019-00587-w

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Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Autor: Javier Garcia Fernandez, Anna Warnecke, Serghei Chercheja, Heidi-Kristin Walter, Lara Pes, Felix Kratz, Federico Medda, Friederike I. Nollmann, Didier Rognan, Steffen Daum, Khalid Abu Ajaj, Patricia Perez Galan, Magnusson Johannes Pall, Koester Stephan David

Publikováno v: Journal of Controlled Release. 296:81-92

Auristatins are a class of highly cytotoxic tubulin-disrupting peptides, which have shown limited therapeutic effect as free agents in clinical trials. In our continuing effort to develop acid-sensitive albumin-binding anticancer drugs exploiting cir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3b07851396b9736b65ff1737d620a1
https://doi.org/10.1016/j.jconrel.2019.01.010

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Abstract 3703: Superior efficacy of novel albumin-binding auristatin E-based prodrugs compared to auristatin E in a panel of human xenograft models in mice

Autor: Felix Kratz, Federico Medda, Javier Garcia Fernandez, Heidi-Kristin Walter, Serghei Chercheja, Anna Warnecke, Lara Pes, Patricia Perez Galan, Magnusson Johannes Pall, Friederike I. Nollmann, Khalid Abu Ajaj, Koester Stephan David

Publikováno v: Cancer Research. 78:3703-3703

Auristatins are highly cytotoxic antimitotic tubulin-binding peptides. Of this family, only Adcetris®, an antibody drug conjugate (ADC) derived from monomethyl auristatin E (MMAE), is approved and marketed. Other auristatins such as dolastatin 10, d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7469cf806f1784d973caebf1dfe7eef
https://doi.org/10.1158/1538-7445.am2018-3703

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Abstract 1657: Structure-activity relationship studies and biological evaluation of novel maytansinoids, a class of highly selective tubulin inhibitors

Autor: Felix Kratz, Federico Medda, Javier Garcia Fernandez, Heidi K. Walter, Friederike I. Nollmann, Lara Pes, Magnusson Johannes Pall, Koester Stephan David, Patricia Perez Galan, Khalid Abu Ajaj, Serghei Chercheja, Anna Warnecke

Publikováno v: Cancer Research. 78:1657-1657

Introduction and objectives: Maytansine and its analogs (DM1 and DM4) are potent microtubule-targeting compounds that inhibit proliferation of cells during mitosis.1 Unfortunately, their narrow therapeutic window prevents a clinical application of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::466f9ca4145cfa741a9f3a066beaeb70
https://doi.org/10.1158/1538-7445.am2018-1657

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Abstract 2661: Novel albumin-binding maytansinoids inducing long-term partial and complete tumor regressions in several human cancer xenograft models in nude mice

Autor: Javier Garcia Fernandez, Lara Pes, Heidi K. Walter, Friederike I. Nollmann, Federico Medda, Magnusson Johannes Pall, Felix Kratz, Anna Warnecke, Koester Stephan David, Serghei Chercheja, Patricia Perez Galan, Khalid Abu Ajaj

Publikováno v: Cancer Research. 78:2661-2661

Introduction and objectives: Maytansine and its analogs (DM1 and DM4) are potent microtubule-targeting compounds that inhibit proliferation of cells during mitosis. Their potent anticancer activity made them attractive for drug development.1 Unfortun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f3ca8028e33eeb29be5711cb138dc59
https://doi.org/10.1158/1538-7445.am2018-2661

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In vivo evaluation of a novel albumin-binding prodrug of doxorubicin in an orthotopic mouse model of prostate cancer (LNCaP)

Autor: Bakheet E. M. Elsadek, Ralph Graeser, K Abu Ajaj, C Tsurumi, Cynthia Schäfer-Obodozie, Tahia H. Saleem, Norbert Esser, Clemens Unger, Anna Warnecke, Felix Kratz

Publikováno v: Prostate cancer and prostatic diseases. 14(1)

PSA, which is overexpressed in prostate carcinoma, represents a molecular target for selectively releasing an anticancer agent from a prodrug formulation. In this study, we report on the in vivo antitumor efficacy of an efficacious albumin-binding pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd167035c4b058fc31af6abedf241f7e
https://pubmed.ncbi.nlm.nih.gov/21042336

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