Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Anna Waller"'
Autor:
Vincent T. Metzger, Daniel C. Cannon, Jeremy J. Yang, Stephen L. Mathias, Cristian G. Bologa, Anna Waller, Stephan C. Schürer, Dušica Vidović, Keith J. Kelleher, Timothy K. Sheils, Lars Juhl Jensen, Christophe G. Lambert, Tudor I. Oprea, Jeremy S. Edwards
Publikováno v:
PeerJ, Vol 12, p e17470 (2024)
TIN-X (Target Importance and Novelty eXplorer) is an interactive visualization tool for illuminating associations between diseases and potential drug targets and is publicly available at newdrugtargets.org. TIN-X uses natural language processing to i
Externí odkaz:
https://doaj.org/article/960d5f8e591045c1b0baec822e03ab67
Autor:
Tudor I Oprea, Larry A Sklar, Jacob O Agola, Yuna Guo, Melina Silberberg, Joshua Roxby, Anna Vestling, Elsa Romero, Zurab Surviladze, Cristina Murray-Krezan, Anna Waller, Oleg Ursu, Laurie G Hudson, Angela Wandinger-Ness
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142182 (2015)
Rho family GTPases (including Rac, Rho and Cdc42) collectively control cell proliferation, adhesion and migration and are of interest as functional therapeutic targets in numerous epithelial cancers. Based on high throughput screening of the Prestwic
Externí odkaz:
https://doaj.org/article/3a07a878906e4afcb571113e8809d423
Autor:
Lin Hong, Yuna Guo, Soumik BasuRay, Jacob O Agola, Elsa Romero, Denise S Simpson, Chad E Schroeder, Peter Simons, Anna Waller, Matthew Garcia, Mark Carter, Oleg Ursu, Kristine Gouveia, Jennifer E Golden, Jeffrey Aubé, Angela Wandinger-Ness, Larry A Sklar
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134317 (2015)
Overactive GTPases have often been linked to human diseases. The available inhibitors are limited and have not progressed far in clinical trials. We report here a first-in-class small molecule pan-GTPase inhibitor discovered from a high throughput sc
Externí odkaz:
https://doaj.org/article/97617ebe8b794147a1d7430ad1a31d97
Autor:
Stella M Bernardo, Christopher P Allen, Anna Waller, Susan M Young, Tudor Oprea, Larry A Sklar, Samuel A Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110354 (2014)
Although three major classes of systemic antifungal agents are clinically available, each is characterized by important limitations. Thus, there has been considerable ongoing effort to develop novel and repurposed agents for the therapy of invasive f
Externí odkaz:
https://doaj.org/article/760d2a3398e9468ba233a01bb72fda69
Autor:
Kishore Polireddy, Mohiuddin Md Taimur Khan, Hemantkumar Chavan, Susan Young, Xiaochao Ma, Anna Waller, Matthew Garcia, Dominique Perez, Stephanie Chavez, Jacob J Strouse, Mark K Haynes, Cristian G Bologa, Tudor I Oprea, George P Tegos, Larry A Sklar, Partha Krishnamurthy
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40005 (2012)
ABCB6 is a member of the adenosine triphosphate (ATP)-binding cassette family of transporter proteins that is increasingly recognized as a relevant physiological and therapeutic target. Evaluation of modulators of ABCB6 activity would pave the way to
Externí odkaz:
https://doaj.org/article/47f376b04fb948fba53161f649e4c7f5
Publikováno v:
Journal of Public Health Management and Practice. 29:369-376
Publikováno v:
Abstracts.
Publikováno v:
Abstracts.
Autor:
Jeremy J. Yang, Lars Juhl Jensen, Tudor I. Oprea, Dhouha Grissa, Cristian Bologa, Christophe G. Lambert, Stephen L. Mathias, Anna Waller, David J. Wild
Publikováno v:
Bioinformatics. 37:3865-3873
Motivation Genome-wide association studies can reveal important genotype–phenotype associations; however, data quality and interpretability issues must be addressed. For drug discovery scientists seeking to prioritize targets based on the available
Publikováno v:
The Journal of Emergency Medicine. 55:769-779
Background Acute pancreatitis is a frequent reason for patient presentation to the emergency department (ED) and the most common gastrointestinal disease resulting in admission. Emergency clinicians are often responsible for the diagnosis and initial