Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Anna Von Rossum"'
Autor:
Matteo Zago, Yun Peng, Meghan M Verstraete, Maya Poffenberger, Veronica Luu, Brenda Ma, Nichole Escalante, Janessa Li, Diego Perez Escanda, Siran Cao, Edward Meier, Sifa Arrafi, Anna Von Rossum, Genevieve Desjardins, Nina Weisser, Thomas Spreter von Kreudenstein
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/ea2578b46f8f41d18390e787ab076115
Autor:
Anna von Rossum, Genevieve Desjardins, Nichole Escalante, Wingkie Wong, Bryant Harbourne, Janessa Li, Begonia Silva Moreno, Prajwal Raghunatha, Richard Kunze, Madeline Fung, Florian Heinkel, Harsh Pratap, Kevin Haworth, Eric Escobar-Cabrera, Brandon Clavette, Surjit Dixit, Nina Weisser, Thomas Spreter von Kreudenstein
Publikováno v:
Cancer Research. 83:2926-2926
Many T-cell engagers (TCE) and immuno-oncology biologics have limited efficacy in the clinic due to narrow therapeutic windows, checkpoint upregulation, and emergence of resistance mechanisms over time. The PROTECTTM (PROgrammed Tumor Engagement & Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58293c19350cbfab787406281d9a14be
https://doi.org/10.1158/1538-7445.am2023-2926
https://doi.org/10.1158/1538-7445.am2023-2926
Autor:
Maya C. Poffenberger, Meghan M. Verstraete, Anna Von Rossum, Patricia Zwierzchowski, Matteo Zago, Veronica Luu, Sifa Arrafi, Siran Cao, Harsh Pratap, Chayne L. Piscitelli, Nina E. Weisser, Thomas Spreter von Kreudenstein
Publikováno v:
Cancer Research. 83:2982-2982
CD3-bispecific T cell engager (TCE) therapies have exhibited clinical utility against hematological malignancies, but successes in solid tumor indications have been limited. Compared to heme malignancies, treatment of solid tumors is hindered by immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5973d138d8e10d3f7bfbf1b4779ae8d
https://doi.org/10.1158/1538-7445.am2023-2982
https://doi.org/10.1158/1538-7445.am2023-2982
Autor:
Charles Stevens, Lisa Newhook, Thomas Spreter, Harsh Pratap, Freiburger Lee, Daniel T. Patton, Duncan Browman, D.M. Mills, Renee Duan, Gesa Volkers, Anna von Rossum, Brandon Clavette, Elizabeth C. Halvorsen, Dimitri Tcaciuc
Publikováno v:
Cancer Research. 81:1737-1737
4-1BB is a TNF family receptor expressed on the surface of tumor-infiltrating T cells. Activation of 4-1BB enhances the activation, metabolism and function of tumor-infiltrating T cells and promotes tumor regression. Several anti-4-1BB antibodies hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcd71700d990ec79de52eb0e7794d0dd
https://doi.org/10.1158/1538-7445.am2021-1737
https://doi.org/10.1158/1538-7445.am2021-1737
Autor:
Gesa Volkers, Javairia Rahim, Florian Heinkel, Anna von Rossum, Leisa Stenberg, Purva Bhojane, Surjit Bhimarao Dixit, Eric Escobar-Cabrera, Thomas Spreter, Sifa Arrafi, Liz Stangle, Harsh Pratap
Publikováno v:
Cancer Research. 81:924-924
Many novel immune-oncology biologics are limited in clinical utility by narrow therapeutic windows. One strategy to overcome this limitation relies on the engineering of ‘masks' that block antibody paratopes outside of the tumor microenvironment (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cb3833799c140fd6d65215bf44db479
https://doi.org/10.1158/1538-7445.am2021-924
https://doi.org/10.1158/1538-7445.am2021-924
Autor:
Anna von Rossum, Grace E. MacEwan, Winnie Enns, Kevin Rey, Jonathan C. Choy, Rajan Cheema, Sukhbir Manku
Publikováno v:
Transplantation. 100:2332-2341
Background IL-6 is an inflammatory cytokine that controls effector T cell responses but the mechanisms by which it controls allogeneic immune responses and vascular rejection that leads to transplant arteriosclerosis (TA) are poorly understood. Metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760a156db3ef68c810a192376a272769
https://doi.org/10.1097/tp.0000000000001227
https://doi.org/10.1097/tp.0000000000001227
Autor:
Yu P. Shi, Jonathan C. Choy, Mehrnoush Malekesmaeli, Anna von Rossum, Ryan R. Brinkman, Winnie Enns, Grace E. MacEwan
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34:1290-1297
Objective— Bim is a proapoptotic Bcl-2 protein known to downregulate immune responses and to also be required for antigen-induced T-cell activation. However, it is not known how the effect of Bim on these offsetting processes determines the outcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bf155d65a2a388da8c812356cc1acb
https://doi.org/10.1161/atvbaha.114.303649
https://doi.org/10.1161/atvbaha.114.303649
Autor:
Grace E. MacEwan, Winnie Enns, Rajan Cheema, Anna von Rossum, Sukh Manku, Kevin Rey, Jonathan C. Choy
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36
Objective: IL-6 is an inflammatory cytokine that controls the development of effector T cell responses but the mechanisms by which it controls allogeneic immune responses and vascular rejection that leads to transplant arteriosclerosis (TA) is poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a96b9bde1cf2dee0afd8001719350b7b
https://doi.org/10.1161/atvb.36.suppl_1.579
https://doi.org/10.1161/atvb.36.suppl_1.579
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 31:1177-1184
Objective— CD155 is a cell surface protein that has recently been described to exert immune regulatory functions. We have characterized the expression of CD155 on human vascular endothelial cells (ECs) and examined its role in the regulation of T-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430a7b5679ee78331abb882ae5c1a2c5
https://doi.org/10.1161/atvbaha.111.224162
https://doi.org/10.1161/atvbaha.111.224162
Autor:
Anna von Rossum, Jean-Luc Boucher, Gerald Krystal, Melisa J. Hamilton, Kevin L. Bennewith, Frann Antignano
Publikováno v:
The Journal of Immunology. 185:4545-4553
Resident tissue macrophages (Mϕs) continually survey the microenvironment, ingesting Ags and presenting them on their surface for recognition by T cells. Because these Ags can be either host cell- or pathogen-derived, Mϕs must be able to distinguis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022bcecda8cec8de5a6f3d11e26577e0
https://doi.org/10.4049/jimmunol.1002045
https://doi.org/10.4049/jimmunol.1002045