Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Anna Visa"'
1
Akademický článek
Tetralol derivative NNC-55-0396 targets hypoxic cells in the glioblastoma microenvironment: an organ-on-chip approach
Autor: Clara Bayona, Lía Alza, Teodora Ranđelović, Marta C. Sallán, Anna Visa, Carles Cantí, Ignacio Ochoa, Sara Oliván, Judit Herreros
Publikováno v: Cell Death and Disease, Vol 15, Iss 2, Pp 1-8 (2024)
Abstract Glioblastoma (GBM) is a highly malignant brain tumour characterised by limited treatment options and poor prognosis. The tumour microenvironment, particularly the central hypoxic region of the tumour, is known to play a pivotal role in GBM p
Externí odkaz: https://doaj.org/article/e4a3f5b50b37495b857d31489a765008
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2
Akademický článek
Tetralol derivative NNC-55-0396 induces glioblastoma cell death by activating IRE1α, JNK1 and calcium signaling
Autor: Anna Visa, Lía Alza, Carles Cantí, Judit Herreros
Publikováno v: Biomedicine & Pharmacotherapy, Vol 149, Iss , Pp 112881- (2022)
Mibefradil and NNC-55–0396, tetralol derivatives with a proven –ability to block T-type calcium channels in excitable cells, reduce cancer cell viability in vitro, causing cell death. Furthermore, they reduce tumor growth in preclinical models of
Externí odkaz: https://doaj.org/article/b5264fb6217f4832842a5e7d8e593bdc
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5
Data from T-Type Cav3.1 Channels Mediate Progression and Chemotherapeutic Resistance in Glioblastoma
Autor: Carles Cantí, Judit Herreros, Maria Santacana, Ricard López-Ortega, Elisabet Talavera, Lía Alza, Oscar Maiques, Marta C. Sallán, Anna Visa
T-type Ca2+ channels (TTCC) have been identified as key regulators of cancer cell cycle and survival. In vivo studies in glioblastoma (GBM) murine xenografts have shown that drugs able to block TTCC in vitro (such as tetralol derivatives mibefradil/N
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46fb94ca4f627a90b66a67da6ce4a451
https://doi.org/10.1158/0008-5472.c.6511353.v1
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6
T-type channels in cancer cells: Driving in reverse
Autor: Judit Herreros, Lía Alza Blanco, Anna Visa, Carles Cantí
Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
In the strongly polarized membranes of excitable cells, activation of T-type Ca2+ channels (TTCCs) by weak depolarizing stimuli allows the influx of Ca2+ which further amplifies membrane depolarization, thus 'recruiting' higher threshold voltage-gate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a589177ca65033c5614d8b9f57a7a5a
https://pubmed.ncbi.nlm.nih.gov/35691056
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7
Targeting T-type channels in cancer: what is on and what is off?
Autor: Judit Herreros, Lía Alza, Adrian Casas-Benito, Carles Cantí, Anna Visa
Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
Over the last 20 years several studies have demonstrated a pivotal role of T‐type calcium channels (TTCCs) in tumor progression. Cytotoxic effects of TTCC pharmacological blockers have been reported in vitro and in preclinical models. However, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2803ca3c62bfc8068dfc5930e2c3aa
http://hdl.handle.net/10459.1/72454
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8
Tetralol derivative NNC-55-0396 induces glioblastoma cell death by activating IRE1α, JNK1 and calcium signaling
Autor: Judit Herreros, Lía Alza Blanco, Carles Cantí, Anna Visa
Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
Mibefradil and NNC-55-0396, tetralol derivatives with a proven ability to block T-type calcium channels in excitable cells, reduce cancer cell viability in vitro, causing cell death. Furthermore, they reduce tumor growth in preclinical models of Glio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87878641617eb203a4532e1ed4fc3eee
https://doi.org/10.1016/j.biopha.2022.112881
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9
FAK inhibition induces glioblastoma cell senescence-like state through p62 and p27
Autor: Lía Alza, Mireia Nàger, Anna Visa, Carles Cantí, Judit Herreros
Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
Cancers, Vol 12, Iss 1086, p 1086 (2020)
Cancers
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Recercat. Dipósit de la Recerca de Catalunya
instname
Volume 12
Issue 5
Focal adhesion kinase (FAK) is a central component of focal adhesions that regulate cancer cell proliferation and migration. Here, we studied the effects of FAK inhibition in glioblastoma (GBM), a fast growing brain tumor that has a poor prognosis. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74836a19b86424080d60968e64841fc3
http://hdl.handle.net/10459.1/68900
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10
The hard-to-close window of T-type calcium channels
Autor: Lía Alza, Judit Herreros, Carles Cantí, Soni Shaikh, Anna Visa
Publikováno v: Repositorio Abierto de la UdL
Universitad de Lleida
Recercat. Dipósit de la Recerca de Catalunya
instname
T-Type calcium channels (TTCCs) are key regulators of membrane excitability, which is the reason why TTCC pharmacology is subject to intensive research in the neurological and cardiovascular fields. TTCCs also play a role in cancer physiology, and ph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438fa4d620d98bc91de3d7f02e27b2b4
https://doi.org/10.1016/j.molmed.2019.03.001
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